Antifungal activity of extracts from Piper aduncum leaves prepared by different solvents and extraction techniques against dermatophytes Trichophyton rubrum and Trichophyton interdigitale

Abstract

The effects of different solvents and extraction techniques upon the phytochemical profile and anti-Trichophyton activity of extracts from Piper aduncum leaves were evaluated. Extract done by maceration method with ethanol has higher content of sesquiterpenes and antifungal activity. This extract may be useful as an alternative treatment for dermatophytosis.

Fur-rubbing withPiperleaves in the San Martín titi monkey,Callicebus oenanthe

“…Constituents of P. aduncum, like dillapiole and other phenylpropanoids, are potent insecticides (Fazolin et al, 2014;Marques and Kaplan, 2015;Pino et al, 2011;Piton et al, 2014;Ribeiro et al, 2016;Vila et al, 2005;Volpe et al, 2015). Extracts of P. aduncum have also been shown to possess antifungal properties (Santos et al, 2013). While it is unclear whether extracts obtained by squeezing the leaves render all these bioactive constituents, it is highly likely that at least some constituents are released.…”

Antimicrobial activity of Piper aduncum leaf extracts against the dental plaque bacteria Streptococcus mutans and Streptococcus sanguinis

“…Results of a previous study have shown that there were differences between the chromatographic profiles of the P. aduncum extracts yielded by different extraction methods. The MAC had the highest content of sesquiterpenes, which accounted for more than 97% of the total identified compounds (Santos et al, 2013). Sesquiterpenes have been extensively described in the literature for their antibacterial properties (Paduch et al, 2007;Saleem et al, 2010), including against S. mutans (Kubo et al, 1992).…”

“…Sesquiterpenes have been extensively described in the literature for their antibacterial properties (Paduch et al, 2007;Saleem et al, 2010), including against S. mutans (Kubo et al, 1992). These latter authors reported that nerolidol, which was one of the most abundant sesquiterpenes present in MAC (Santos et al, 2013), has potent activity against S. mutans, with MIC of 0.025 mg/ml (Kubo et al, 1992). Thus, the good performance of the MAC and its J fraction can be related to their high content of sesquiterpenes.…”

Antifungal activity and mechanism of heat-transformed ginsenosides from notoginseng against Epidermophyton floccosum, Trichophyton rubrum, and Trichophyton mentagrophytes

“…Dermatophytes are a group of fungi that induce dermatophytosis (commonly known as ringworm or tinea) of human keratinous tissues such as skin, hair, and nails. 1 According to the data of the World Health Organization, dermatophytes affected about 25% of the world population with dermatophytosis. 2 Among the fungal species isolated from infected skins, Epidermophyton occosum (E. occosum), Trichophyton rubrum (T. rubrum), and Trichophyton mentagrophytes (T. mentagrophytes) were the three frequent dermatophytes in clinical cases of tinea pedis, tinea unguium, tinea corporis, and tinea cruris.…”