Pasteurella multocida bacterial meningitis caused by contact with pigs

López, Cecilia; Sanchez-Rubio, P.; Betrán, Ana Pilar; Terré, R.

doi:10.1590/s1517-83822013000200021

Cited by 10 publications

(8 citation statements)

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“…In the literature, the main risk factor for P. multocida meningitis is an animal contact, which has been reported in 84 % of cases [ 2 ]. To our knowledge, only 48 adult cases of meningitis caused by P. multocida in immunocompetent and immunodeficiency patients have been reported [ 2 – 5 ]. Only nine cases of neurological complications have been reported including epidural empyema, cerebrals abscess, convulsion, cognitive deficit, paralysis, acute disseminated encephalomyelitis and meningoencephalitis [ 2 – 5 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

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Meningitis caused by Pasteurella multocida in a dog owner without a dog bite: clonal lineage identification by MALDI-TOF mass spectrometry

et al. 2015

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BackgroundPasteurella multocida meningitis in an immunocompetent patient is rare and commonly occurs after animal bite. To our knowledge, only 48 cases have been reported in the literature since 1989. P. multocida meningitis is commonly linked to animal contagion. Here we report on a new case of P. multocida meningitis in an immunocompetent patient who is a dog owner without a dog bite. We used the matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) mass spectrometry to investigate the clonal lineage between animal and human isolates.Case presentationIn our case, a 25-year-old immunocompetent French Caucasian woman with nothing notable in her medical history was admitted for meningitis caused by P. multocida. Clonal lineage of P. multocida strains from cerebrospinal fluid and blood culture and her dog’s oral cavity has been recognized by MALDI-TOF mass spectrometry dendrograms and clustering of the 21 P. multocida isolates in our centres. She was treated by a combination of intravenous ceftriaxone (2 g/day) and oral levofloxacin (1 g/day). She was discharged on the 6th day of admission. The antimicrobial therapy was conducted for 15 days. The dog was treated by clavulanic-acid amoxicillin for 3 weeks by the veterinarian. The evolution of the patient at the 5th month after the end of the antimicrobial therapy was normal without any neurological after-effects.ConclusionThe meningitis caused by P. multocida could be considered a cause of human meningitis in dog lovers without an animal bite. MALDI-TOF mass spectrometry should be considered as it is an accurate tool to identify clonal lineage between animal and human isolates.

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Section: Discussionmentioning

confidence: 99%

“…Pasteurella multocida are small Gram-negative coccobacilli which appeared to be a common flora in oral cavity of dogs and cats [ 1 ]. Skin and soft tissue infection is a main human pasteurelloses; and P. multocida meningitis in an immunocompetent patient is rare and commonly occurred after animal bite [ 2 – 5 ].…”

Section: Introductionmentioning

confidence: 99%

Meningitis caused by Pasteurella multocida in a dog owner without a dog bite: clonal lineage identification by MALDI-TOF mass spectrometry

et al. 2015

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“…The occurrence of P. multocida in other species has also been reported, such as pasteurellosis ('snuffles') in rabbits, fowl cholera in poultry, hemorrhagic septicemia in ruminants and animal scratches and bites in humans (ARUMUGAM et al, 2011;ASHRAF et al, 2011;LÓPEZ et al, 2013;WILSON & HO, 2013RAVAL et al, 2014 (KICH et al, 2007). P. multocida is a Gram-negative bacterium grouped into five capsular serogroups (A, B, D, E and F) and is further classified into 16 somatic serotypes according to the lipopolysaccharide antigen (HEDDLESTON, 1972;PIJOAN, 2006;BOROWSKY et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Molecular characterization of Pasteurella multocida isolates from swine lungs by Randomly Amplified Polymorphic DNA

et al. 2015

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“…The authors suggested a similar route of transmission in 5 of 8 pig farmers in Japan with diagnosed porcine streptococcosis. Pig bite is regarded by many authors as an important transmission route of zoonotic pathogens [70][71][72][73], mostly Gram-negative species Pasteurella multocida and Pasteurella aerogenes [72,73]. Nevertheless, Barnham [70], who analyzed 7 cases of febrile infections in pig farmers caused by pig bite or boar's tusk gore, isolated from these patients, together with Pasteurella spp., also the haemolytic Streptococcus strains (identified as S. anginosus, S. agalactiae and S. dysagalactiae subsp.…”

Section: Relevance To Occupationmentioning

confidence: 99%

Streptococcus suis: a re-emerging pathogen associated with occupational exposure to pigs or pork products. Part I – Epidemiology

Dutkiewicz

Sroka²,

Zając³

et al. 2017

Ann Agric Environ Med.

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Streptococcus suis (ex Elliot 1966, Kilpper-Bälz & Schleifer 1987) is a facultatively anaerobic Gram-positive ovoid or coccal bacterium surrounded by a polysaccharide capsule. Based on the antigenic diversity of the capsule, S. suis strains are classified serologically into 35 serotypes. Streptococcus suis is a commensal of pigs, commonly colonizing their tonsils and nasal cavities, mostly in weaning piglets between 4-10 weeks of age. This species occurs also in cattle and other mammals, in birds and in humans. Some strains, mostly those belonging to serotype 2, are also pathogenic for pigs, as well as for other animals and humans. Meningitis is the primary disease syndrome caused by S. suis, both in pigs and in humans. It is estimated that meningitis accounted for 68.0% of all cases of human disease reported until the end of 2012, followed by septicaemia (including life-threatening condition described as 'streptococcal toxic shock-like syndrome' - STSLS), arthritis, endocarditis, and endophthalmitis. Hearing loss and/or ves tibular dysfunction are the most common sequelae after recovery from meningitis caused by S. suis, occurring in more than 50% of patients. In the last two decades, the number of reported human cases due to S. suis has dramatically increased, mostly due to epidemics recorded in China in 1998 and 2005, and the fulminant increase in morbidity in the countries of south-eastern Asia, mostly Vietnam and Thailand. Out of 1,642 cases of S. suis infections identified between 2002-2013 worldwide in humans, 90.2% occurred in Asia, 8.5% in Europe and 1.3% in other parts of the globe. The human disease has mostly a zoonotic and occupational origin and occurs in pig breeders, abattoir workers, butchers and workers of meat processing facilities, veterinarians and meat inspectors. Bacteria are transmitted to workers by close contact with pigs or pig products, usually through contamination of minor cuts or abrasions on skin of hands and/or arms, or by pig bite. A different epidemiologic situation occurs in the Southeast Asian countries where most people become infected by habitual consumption of raw or undercooked pork, blood and offal products in the form of traditional dishes. Prevention of S. suis infections in pigs includes vaccination, improvement in pig-raising conditions, disinfection and/or fumigation of animal houses, and isolation of sick animals at the outbreak of disease. Prevention of human infections comprises: protection of skin from pig bite or injury with sharp tools by people occupationally exposed to pigs and pig products, prompt disinfection and dressing of wounds and abrasions at work, protection of the respiratory tract by wearing appropriate masks or repirators, consulting a doctor in the case of febrile illness after exposure to pigs or pork meat, avoidance of occupations associated with exposure to pigs and pork by immunocompomised people, avoidance of consumption of raw pork or pig blood, adequate cooking of pork, and health edu...

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Pasteurella multocida bacterial meningitis caused by contact with pigs

Cited by 10 publications

References 8 publications

Meningitis caused by Pasteurella multocida in a dog owner without a dog bite: clonal lineage identification by MALDI-TOF mass spectrometry

Meningitis caused by Pasteurella multocida in a dog owner without a dog bite: clonal lineage identification by MALDI-TOF mass spectrometry

Molecular characterization of Pasteurella multocida isolates from swine lungs by Randomly Amplified Polymorphic DNA

Streptococcus suis: a re-emerging pathogen associated with occupational exposure to pigs or pork products. Part I – Epidemiology

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