Viability of stressed Mycobacterium tuberculosis and association with multidrug resistance

Abstract

This study investigated biological characteristics of recovered stressed M. tuberculosis isolates that failed to grow in differential culture media for phenotypic identification and in culture media containing anti-tuberculosis drugs for drug-susceptibility testing, despite of having grown in primary culture. It represents an improvement in the diagnosis of MDR tuberculosis and tuberculosis control.

A systematic review of East African-Indian family of Mycobacterium tuberculosis in Brazil

“…The EAI family is rare in Brazil, occurring typically at frequencies below 2% of the datasets analyzed ( Table 2 ). While EAI family isolates were found in the North, 22 , 24 Northeast, 19 , 22 South, 14 , 16 , 26 and Southeast of Brazil, 15 , 17 , 18 , 20 , 21 , 22 , 23 , 27 the highest circulation of this family was reported in the North (Pará) 22 ( Table 2 ). The number of EAI isolates varied from only one to as many as 15 in the studies reviewed ( Table 2 ).…”

“…2 and Table 2 ). 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 Most of these were either based on bacterial collections maintained in reference laboratories that perform culturing for species identification and phenotypic drug-susceptibility testing, 14 , 16 , 17 , 18 , 20 , 21 , 24 , 26 , 27 or on convenience sampling of TB patients at reference health care units responsible for TB diagnosis. 15 , 22 , 23 , 25 One report consisted of a case-control study involving drug-sensitive versus drug-resistant TB patients.…”