Efficacy evaluation of some antibiotics against syrian brucella spp isolates, in vitro

Safi, Mazen; Al-Mariri, Ayman

doi:10.1590/s1517-83822012000400005

Cited by 7 publications

(3 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ciprofloxacin, doxycycline, and oxytetracycline were the most effective antibiotics. Resistance to rifampin (51%), streptomycin (100%), and tetracycline (39%) was seen in 100 B. melitensis isolated between 2004 and 2007 (Safi & Al‐Mariri, 2012). In addition, 23 B. melitensis strains from Mediterranean (Israel and Turkey) and African countries were analyzed in Norway (Johansen et al., 2018).…”

Section: Resultsmentioning

confidence: 99%

The perspective of antibiotic therapeutic challenges of brucellosis in the Middle East and North African countries: Current situation and therapeutic management

Wareth

Dadar

Ali

et al. 2022

Transbounding Emerging Dis

View full text Add to dashboard Cite

Brucellosis is among the most prevalent zoonotic infections in Middle Eastern and North African (MENA) countries, critically impacting human and animal health. A comprehensive review of studies on antibiotic susceptibility and therapeutic regimes for brucellosis in ruminants and humans in the MENA region was conducted to evaluate the current therapeutic management in this region. Different scientific databases were searched for peer‐reviewed original English articles published from January 1989 to February 2021. Reports from research organizations and health authorities have been taken into consideration. Brucella melitensis and Brucella abortus have been reported from the majority of MENA countries, suggesting a massive prevalence particularly of B. melitensis across these countries. Several sporadic cases of brucellosis relapse, therapeutic failure, and antibiotic resistance of animal and human isolates have been reported from the MENA region. However, several studies proved that brucellae are still in‐vitro susceptible to the majority of antibiotic compounds and combinations in current recommended World Health Organization (WHO) treatment regimens, for example, levofloxacin, tetracyclines, doxycycline, streptomycin, ciprofloxacin, chloramphenicol, gentamicin, tigecycline, and trimethoprim/sulfamethoxazole. The current review presents an overview on resistance development of brucellae and highlights the current knowledge on effective antibiotics regimens for treating human brucellosis.

show abstract

Section: Resultsmentioning

confidence: 99%

The perspective of antibiotic therapeutic challenges of brucellosis in the Middle East and North African countries: Current situation and therapeutic management

Wareth

Dadar

Ali

et al. 2022

Transbounding Emerging Dis

View full text Add to dashboard Cite

show abstract

“…Fluoroquinolones have been tried experimentally to treat brucellosis by several researchers; however, the results do not support their usage as first-line therapy ( Safi and Al-Mariri, 2012 ). Due to the distinct characteristics of brucellosis, medical professionals and microbiologists need to collaborate closely to properly diagnose, track, and treat brucellosis in humans.…”

Section: Clinical Symptoms In Humansmentioning

confidence: 99%

Brucellosis: Unveiling the complexities of a pervasive zoonotic disease and its global impacts

Khairullah,

Kurniawan,

Puspitasari

et al. 2024

Open Vet J

View full text Add to dashboard Cite

One zoonotic infectious animal disease is brucellosis. The bacteria that cause brucellosis belong to the genus Brucella. Numerous animal and human species are affected by Brucellosis, with an estimated 500,000 human cases recorded annually worldwide. The occurrence of new areas of infection and the resurgence of infection in already infected areas indicate how dynamically Brucellosis is distributed throughout different geographic regions. Bacteria originate from the blood and are found in the reticuloendothelial system, the liver, the spleen, and numerous other locations, including the joints, kidneys, heart, and genital tract. Diagnosis of this disease can be done by Bacterial Isolation, Molecular tests, Modified acid-fast Stain, Rose Bengal Test (RBT), Milk Ring Test (MRT), Complement Fixation Test (CFT), Enzyme-Linked Immunosorbent Assay (ELISA), and Serum Agglutination Test (SAT). The primary sign of a B. abortus infection is infertility, which can result in abortion and the birth of a frail fetus that may go on to infect other animals. In humans, the main symptoms are acute febrile illness, with or without localization signs, and chronic infection. Female cattle have a greater risk of contracting Brucella disease. Human populations at high risk of contracting brucellosis include those who care for cattle, veterinarians, slaughterhouse employees, and butchers. Antibiotic treatment of brucellosis is often unsuccessful due to the intracellular survival of Brucella and its adaptability in macrophages. A 'One Health' strategy is necessary to control illnesses like brucellosis.

show abstract

“…En nuestro reporte, el padre, la tía y la prima, quienes tomaron doxiciclina y rifampicina como segunda terapia mostraron resultados negativos en serología y RPC al final del seguimiento. Resultados parecidos fueron reportados por Buzgan y cols., en pacientes con complicaciones ostearticulares 33 , en contraste con los hallazgos de otros autores quienes reportaron que esta combinación fue la menos efectiva en el tratamiento de casos humanos 34,35 . En los casos de las pacientes con DM2 no mostraron mejoría después del tratamiento con doxiciclina y rifampicina.…”

Section: Wwwsochinfclunclassified

Seguimiento clínico, serológico y mediante la reacción de polimerasa en cadena de una familia con brucelosis

Morales-García¹,

García-Méndez²,

Regalado-Jacobo³

et al. 2014

Rev. chil. infectol.

View full text Add to dashboard Cite

Efficacy evaluation of some antibiotics against syrian brucella spp isolates, in vitro

Cited by 7 publications

References 26 publications

The perspective of antibiotic therapeutic challenges of brucellosis in the Middle East and North African countries: Current situation and therapeutic management

The perspective of antibiotic therapeutic challenges of brucellosis in the Middle East and North African countries: Current situation and therapeutic management

Brucellosis: Unveiling the complexities of a pervasive zoonotic disease and its global impacts

Seguimiento clínico, serológico y mediante la reacción de polimerasa en cadena de una familia con brucelosis

Contact Info

Product

Resources

About