The use of ozonized oil in the treatment of dermatophitosis caused by Microsporum canis in rabbits

Abstract

The ozone is effective against most microorganisms due to its high oxidant power. Low concentrations and short-term contact are sufficient to inactivate bacteria, mold, yeast, parasites, seaweeds, protozoa and fungi. Microsporum canis is an important agent of dermatophitosis in human and animal. The aim of the current study was to assess the efficacy of ozonized oil over Microsporum canis in rabbits. Eighteen male New Zealand white rabbits, weight ranging from 2 to 3.2 kg were depilated in the cranial dorso-lateral and right caudal, and cranial and left caudal regions. The regions were inoculated with Microsporum canis, excepting the right caudal region, and were denominated TM, O, OM and M, respectively. After seven days, the treatment of lesions in TM began with 0.12g of terbinaphine 1% cream; in OM and O with 0.12g of ozonized oil; all animals were treated once a day for 28 days. Region M was not treated. Material was collected from those regions for cultivation in Sabouraud agar at day 28 of treatment. In the evolution of the treatment with terbinaphine, of 14 contaminated regions with Microsporum canis ten evolved to cure.With the ozonized oil, of 15 contaminations, four were cured. Clinically, that is, the macroscopic evaluation of lesions showed improvement in the TM and OM treated regions. We can conclude that there was statistical evidence of the protection action of the oil against the dermatophyte.

Synthesis, characterization, thermal behavior, and biological activity of ozonides from vegetable oils

“…5 However, a recent study suggested that not only the ozonation grade is important to improve the healing process of the wound but also the typical composition of the oil. 2 Ozonated oils from sunflower, olive, sesame, soybean and linseed oils are the most extensively studied with respect to their biological [1][2][3][4][5][6][7][8][9][10][11][12] and physicochemical 5,[13][14][15][16][17][18][19] properties. Other products, such as ozonated grape seed 19 , theobroma 20 , coconut 21 , jojoba 22 , rapeseed and corn 23 oils have also been investigated.…”

Effects of boron compounds and ozonated olive oil on experimental Microsporum canis ınfection in rats

“…Geweely [19] used ozonated olive oil to successfully treat infections of Aspergillus fumigatus, Candida albicans, Epidermophyton floccosum, M. canis, and Trichopyton rubrum. Daud et al [20] reported considerable improvements in rabbits that were experimentally infected with M. canis and subsequently treated with 1% terbinafine cream and ozonized sunflower oil. In this study, the topical ozonated olive oil treatment group showed positive outcomes in comparison with the untreated control group; however, these results were not as good as those of groups treated with boron-based creams.…”

Ozônio no controle microbiano em patógenos capilares

“…Foi utilizada uma pomada de Terbinafina, normalmente utilizada em fungos e dermatófitos, em comparação com 0,12g de óleo ozonizado. A Terbinafina demonstrou maior eficácia em relação ao ozônio, porém o O3 causou menor agressão a epiderme do animal (DAUD, 2011). Sendo de conhecimento que o tratamento sistêmico com antifúngicos, principalmente com o uso a longo prazo, possui efeitos colaterais, alternativas como o uso do ozônio vem sendo estudadas por sua forte propriedade germicida contra vírus, bactérias, parasitas e fungos.…”