Oral administration of piperine for the control of aflatoxin intoxication in rats

Gagini, Thalita B.; Silva, Robson E.; Castro, I. S.; Soares, Breno A.; Lima, Marco Edílson Freire de; Brito, Marilene F.; Mazur, Carlos; Direito, Glória Maria; Danelli, Maria das Graças Miranda

doi:10.1590/s1517-83822010000200013

Cited by 10 publications

(9 citation statements)

References 9 publications

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“…Cardoso et al (2009), while working with broiler chickens, found that orally administered piperine did not interfere on weight gain or liver relative weight. However, liver histopathological changes were observed in a dose-dependent manner, indicating that 1.12 mg kg -1 of piperine, with oral route of administration, is nontoxic for broiler chickens, as previously reported for rats and mice (Dogra et al, 2004;Gagini et al, 2010).…”

Section: Introductionsupporting

confidence: 79%

Piperine as a phytogenic additive in broiler diets

Cardoso

Lima

et al. 2012

Pesq. agropec. bras.

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-The objective of this work was to determine the effect of piperine as a phytogenic additive in chicken broiler diet. Seven-day-old male chicks were randomly allocated in four experimental treatments (n = 24), with four replicates (n = 6). The piperine was added to diets at concentrations of 0, 60, 120, and 180 mg kg -1 for 35 consecutive days. The following were evaluated: biochemical, hematological and histopathological parameters; performance and carcass yield. Histomorphometric analyses were also carried out. The addition of 120 and 180 mg kg -1 of piperine did not alter broiler body weight and feed conversion, whereas 60 mg kg -1 of piperine interfered positively in both parameters from 36 to 42 days of age and significantly increased the absorption surface of the duodenum and the ileum. No macroscopic alteration in organ size and color was observed in the broilers fed diets with the evaluated concentrations of piperine. The supplementation of 120 and 180 mg kg -1 of piperine is toxic to liver tissue and reduces the absorption surface of the jejune. The diet supplemented with 60 mg kg -1 of piperine is safe.Index terms: Piper nigrum, performance, phytogenic additive, sanitation. Piperina como suplemento fitogênico na dieta de frangos de corteResumo -O objetivo deste trabalho foi determinar o efeito da piperina, como suplemento fitogênico, na dieta de frangos de corte. Pintos com sete dias de idade foram distribuídos aleatoriamente em quatro tratamentos (n = 24), com quatro repetições (n = 6). A piperina foi adicionada na ração nas concentrações de 0, 60, 120 e 180 mg kg

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Section: Introductionsupporting

confidence: 79%

Piperine as a phytogenic additive in broiler diets

Cardoso

Lima

et al. 2012

Pesq. agropec. bras.

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“…Some phytobiotics act as growth promoters and others can neutralize the toxic effects of xenobiotics like AFB 1 [43,49,50]. The covalent bonding of AFB 1 -epoxide with DNA modifies the structure of the nucleic acid and biological activity, generating RNA and DNA adducts with potential mutagenic, carcinogenic and teratogenic characteristics [51].…”

Section: Resultsmentioning

confidence: 99%

“…Aliquots of these solutions were prepared in the concentration of 0.5 mg·kg −1 body weight of chicken and administered daily by gavage, starting with a 10-day-old broiler. The methodology was adapted from Gagini et al [43]. …”

Section: Methodsmentioning

confidence: 99%

“…Reen et al [37] showed that piperine was able to significantly decrease the toxicity of AFB 1 in rat hepatocytes in vitro and Selvendiran et al [41,42] demonstrated the protective effects of piperine against cytotoxic and genotoxic carcinogenesis induced by certain chemical carcinogens and AFB 1 . Gagini et al [43] showed that piperine treatment in intoxicated rats decreased hepatic injuries and leukocyte depletion over a 23 day-period. Previous studies by our group have demonstrated that piperine intake decreased the severity of the toxic effects of aflatoxins in broiler chickens, preventing the development of liver injury and the adverse effects on hematological parameters, which are characteristic of aflatoxicosis.…”

Section: Introductionmentioning

confidence: 99%

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Antigenotoxic Effect of Piperine in Broiler Chickens Intoxicated with Aflatoxin B1

Cardoso

Vermelho

Lima

et al. 2016

Toxins

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Piperine is an abundant amide extracted from black pepper seeds which has been shown to have protective effects against cytotoxic and genotoxic carcinogenesis induced by certain chemical carcinogens and aflatoxin B1 (AFB1) in vitro. The aim of this work was to study, in vivo, the antigenotoxic potential of feed-added piperine on broiler chickens experimentally intoxicated with AFB1, using micronucleus and comet assays. The antigenotoxicity assessment of 9-day-old chicks was performed on a total of 60 chickens divided into four groups of 15 broilers each: (C) control, (P) 60 mg·piperine kg−1 feed, (A) 0.5 mg·AFB1·kg−1 body weight, (daily by oral route), and (P + A) co-treatment with piperine and AFB1. The experiment was conducted for 26 days. Chicks intoxicated with AFB1 showed significant genotoxic effects in the first 24 h post intoxication, and the effects remained in the other periods analyzed (48, 72, and 96 h and 26 days of treatment). The DNA damage in peripheral blood cells, the number of erythrocytes with micronuclei, and polychromatic-to-normochromatic erythrocyte ratio were significantly reduced or absent in the piperine/AFB1 group. No significant differences were observed between the group piperine/AFB1 and the control and piperine-alone groups. The addition 60 mg·kg−1 of piperine to the diet of the broiler chicks was safe, promoting beneficial effects in poultry health with respect to the toxic effects 0.5 mg·AFB1·kg−1 body weight.

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“…A further study investigated the toxic effects of piperine on the liver [144]. After the administration of 1.12 mg/kg b.w./day for 23 days, no histopathological lesions were observed.…”

Section: Toxicological Studiesmentioning

confidence: 99%

Overview of the Anticancer Potential of the “King of Spices” Piper nigrum and Its Main Constituent Piperine

Turrini

Sestili

Fimognari

2020

Toxins

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The main limits of current anticancer therapy are relapses, chemoresistance, and toxic effects resulting from its poor selectivity towards cancer cells that severely impair a patient’s quality of life. Therefore, the discovery of new anticancer drugs remains an urgent challenge. Natural products represent an excellent opportunity due to their ability to target heterogenous populations of cancer cells and regulate several key pathways involved in cancer development, and their favorable toxicological profile. Piper nigrum is one of the most popular spices in the world, with growing fame as a source of bioactive molecules with pharmacological properties. The present review aims to provide a comprehensive overview of the anticancer potential of Piper nigrum and its major active constituents—not limited to the well-known piperine—whose undeniable anticancer properties have been reported for different cancer cell lines and animal models. Moreover, the chemosensitizing effects of Piper nigrum in association with traditional anticancer drugs are depicted and its toxicological profile is outlined. Despite the promising results, human studies are missing, which are crucial for supporting the efficacy and safety of Piper nigrum and its single components in cancer patients.

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Oral administration of piperine for the control of aflatoxin intoxication in rats

Cited by 10 publications

References 9 publications

Piperine as a phytogenic additive in broiler diets

Piperine as a phytogenic additive in broiler diets

Antigenotoxic Effect of Piperine in Broiler Chickens Intoxicated with Aflatoxin B1

Overview of the Anticancer Potential of the “King of Spices” Piper nigrum and Its Main Constituent Piperine

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