Human respiratory syncytial virus detection in children admitted at a community hospital in Botucatu, SP, Brazil

Bosso, Patrícia Alves Ramos; Candeias, J. A. N.; Paduan, Karina dos Santos; Ricchetti, Sandra M. Q.; Miranda, Antero F. M.; Rugolo, Lígia Maria Suppo de Souza; Durigon, Edison Luiz; Ventura, Armando Morais

doi:10.1590/s1517-83822004000300015

Cited by 8 publications

(6 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…RSV was present in 30% of the subjects below 1 year old and in 50% of the subjects below 3 months of age. This tendency toward younger age in RSV infections has been reported in others studies [4,[11][12][13]. Anatomic and physiologic aspects might be indicated as responsible by a greater severity and need for hospitalization in the younger age [14].…”

Section: Discussionsupporting

confidence: 62%

See 1 more Smart Citation

Incidence and clinical characteristics of the infection by the Respiratory Syncytial Virus in children admitted in Santa Casa de São Paulo Hospital

Pecchini¹,

Berezin²,

Felício³

et al. 2008

Braz J Infect Dis

View full text Add to dashboard Cite

The purpose of this study was to identify the rate of infections due to RSV and other viruses in children. In addition we have analyzed demographic data and clinical characteristics of the RSV-positive patients comparing with patients infected by other respiratory viruses. We also described the seasonality of the RSV occurrence in a hospital in 37%). We divided the subjects in 3 groups: Group 1 RSV-Positive, Group 2 Other Positive Viruses and Group 3 Negative for Respiratory Virus. Mean age (months) was of 7.5 for RSVpositive children, 7.6 for other viruses, and 8 for negative for respiratory virus. The RSV-Positive Group was significantly younger than the Group Negative for Respiratory Virus (p<0.05). Signs of UAI were more present in the Positive RSV Group (p<0.05). General mortality was of 2.41%. There was a higher incidence of RSV between the months of March and August in the two years of the study. Our study indicates RSV as the most prevalent viral agent in children admitted due to (ARI), especially in infants below 3 months old. We have also found that infections due to RSV can occur in months others than the classic seasonal period.

show abstract

Section: Discussionsupporting

confidence: 62%

“…Bosso et al [12] (2004) have also found an incidence peak of RSV outside the seasonal period in a study performed in Botucatu, São Paulo state, when evaluating the incidence of that virus in children below 2 years old.…”

Section: Discussionmentioning

confidence: 93%

Incidence and clinical characteristics of the infection by the Respiratory Syncytial Virus in children admitted in Santa Casa de São Paulo Hospital

Pecchini¹,

Berezin²,

Felício³

et al. 2008

Braz J Infect Dis

View full text Add to dashboard Cite

show abstract

“…In spite of the fact that infants are relatively immature in their ability to mount immune response to respiratory virus infections, maternal antibodies are an important means of protection (Crowe 2001). Although Glezen et al (1981) suggested that infants with high levels of maternal RSV-neutralizing antibodies developed mild illness, lactates and young children are the groups most affected by RSV (Queiróz et al 2002, Checon et al 2002, Bosso et al 2004. Also, it still remains unclear whether the severity of RSV infection could be triggered by cross-reactivity between RSV subtype-specific maternal antibodies and a different RSV variant.…”

Section: Discussionmentioning

confidence: 99%

“…In regions with lower temperatures during winter, such as São Paulo (Vieira et al 2001), Botucatu (Bosso et al 2004), and Porto Alegre (Strallioto et al 2001) cities, RSV circulation extended to July or August (mid-winter). Thus, it seems that RSV circulation accompanies low temperatures.…”

Section: Discussionmentioning

confidence: 99%

Respiratory viruses in children younger than five years old with acute respiratory disease from 2001 to 2004 in Uberlândia, MG, Brazil

Costa

Yokosawa²,

Mantese³

et al. 2006

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

The main viruses involved in acute respiratory diseases among children are: respiratory syncytial virus (RSV), influenzavirus (FLU), parainfluenzavirus (PIV), adenovirus (AdV), human rhinovirus (HRV), and the human metapneumovirus (hMPV). The purpose of the present study was to identify respiratory viruses that affected children younger than five years old in Uberlândia, Midwestern Brazil. Nasopharyngeal aspirates from 379 children attended at Hospital de Clínicas (HC/UFU), from 2001 to 2004, with acute respiratory disease, were collected and tested by immunofluorescence assay (IFA) to detect RSV, FLU A and B, PIV 1, 2, and 3 and AdV, FLU A and B in 9.5% (36/379), PIV 1, 2 and 3 in 6.3% (24/ 379) and AdV in 3.7% (14/379). HRV were detected in 29. 6% (112/379) Viruses are the most frequent agents that cause acute respiratory infections (ARIs) and are responsible for a considerable percentage of childhood mortality (Williams et al. 2002). In Brazil, some reports from different geographical areas has revealed the viruses as the main cause of respiratory infections, as related in the cities of Fortaleza (Arruda et al. 1991), Rio de Janeiro (Nascimento et al. 1991), São Paulo (Miyao et al. 1999, Vieira et al. 2001), and Curitiba (Tsuchiya et al. 2005.The most important viruses involved in ARI are: respiratory syncytial virus (RSV), influenzaviruses types A and B (FLU A/B), parainfluenzavirus (PIV), adenovirus (AdV), human rhinovirus (HRV), and the human metapneumovirus (hMPV) (Miyao et al. 1999, Kuiken et al. 2003, Tsuchiya et al. 2005). The last one was recently identified by Hoogen et al. (2001).RSV is the main cause of viral lower respiratory tract illness in children (Miyao et al. 1999), particularly in those younger than six months old (mo.) (Queiróz et al. 2002. In addition, RSV infections are responsible for most cases of severe symptoms such as bronchiolitis with recurrent wheezing and pneumonia (Calegari et FLU is a serious public health problem worldwide, were children constitute the age group most affected (Neuzil et al. 2002). Although many infections caused by FLU could be prevented by effective vaccination program, it has been predicted that a pandemic is likely to emerge in a near future (Cox et al. 2003), caused by a virus variant not covered by the current vaccine, requiring, thus, a constant epidemiological surveillance.PIV seems to have pattern of seasonal occurrence and is considered an important cause of respiratory illnesses, particularly among young children (Monto 2002).AdV infections are common in all age groups, causing both hospital-and community-acquired epidemics. Moreover, AdV has been associated with hospitalizations of near-fatal asthma patients (Tan et al. 2003) and with cases of acute otitis media in children younger than two years old (Monobe et al. 2003).HRV is responsible for the majority of common colds during winter, causing upper respiratory infections (Arruda et al. 1991, Savolainen et al. 2003 and is considered a risk factor for acute otitis media (Monobe at al. 2003). ...

show abstract

“…The sensitivity of the reaction was determined to be sufficient to detect a minimum of 0.1 TCID 50 . HRSV species A and B RNA were detected with a pair of primers directed to the F and G proteins (Bosso et al 2004). Sensitivity of the reverse transcription-PCR (RT-PCR) was determined to be sufficient to detect 6.59 TCID 50 of HRSV-A and 1.405 TCID 50 of HRSV-B (Nascimento et al 2008).…”

mentioning

confidence: 99%

Duplex-PCR assay for the detection of adenovirus and respiratory syncytial virus in nasopharyngeal samples

Marinheiro

Sanalios

Santos

et al. 2009

Mem. Inst. Oswaldo Cruz

View full text Add to dashboard Cite

show abstract

Human respiratory syncytial virus detection in children admitted at a community hospital in Botucatu, SP, Brazil

Cited by 8 publications

References 26 publications

Incidence and clinical characteristics of the infection by the Respiratory Syncytial Virus in children admitted in Santa Casa de São Paulo Hospital

Incidence and clinical characteristics of the infection by the Respiratory Syncytial Virus in children admitted in Santa Casa de São Paulo Hospital

Respiratory viruses in children younger than five years old with acute respiratory disease from 2001 to 2004 in Uberlândia, MG, Brazil

Duplex-PCR assay for the detection of adenovirus and respiratory syncytial virus in nasopharyngeal samples

Contact Info

Product

Resources

About