Multidrug-resistant tuberculosis among male inmates in Rio de Janeiro, Brazil

Lourenço, Maria Cristina da Silva; Silva, Marlei Gomes da; Fonseca, Leila de Souza

doi:10.1590/s1517-83822000000100005

Cited by 6 publications

(6 citation statements)

References 11 publications

(11 reference statements)

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“…Epidemiologic studies have shown that risk of TB increases with close contacts of sputum-smear-positive patients and that the prevalence of clinical disease among intimate contacts of TB cases is high [ 6 ]. Similarly, there are growing fears that the high rate of TB in prisons coupled with weak health care systems are contributing to the emergence of Multi-Drug Resistant Tuberculosis (MDRTB) strains [ 7 ]. This study therefore, sought to find out the prevalence of tuberculosis among prison inmates at Mbarara central prison, Kiswahili cell Mbarara District, South Western Uganda.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Pulmonary Tuberculosis among Prison Inmates at Mbarara Central Prison, South Western Uganda

Owokuhaisa

Thokerunga

Bazira

2014

AIR

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Aims This study was conducted to determine the prevalence of tuberculosis among prison inmates at Mbarara Central prison Design A cross sectional study was carried out at Mbarara Central Prison in Mbarara district, Kiswahili cell in Mbarara municipality among female and male prison in mates between June 2012 to August 2012. A questionnaire was administered to each prison inmate who consented in writing and two sputum specimens were collected and examined by Ziehl-Neelsen technique. Results At the time of the study, the prison had 900 inmates (both males and females). A total of 648 in mates were screened and 248 inmates enrolled in the study. Of the 248 inmates, 5 inmates were new cases of TB while 29 inmates were already on TB treatment. The median age of participants was 28 years (23.5-33 IQR) and 96.4% were males with majority (22.6%) coming from Mbarara as a home district. The participants had stayed in prison for a median duration of 2 years (1-3 IQR) and 23.7% had ever been in prison before. The median number of inmates per cell was 140 (138-149 IQR) and inmates (female and male) had a body mass index of 21.4 (19.9-22.6 IQR) and 20.2 (19.2-26.7 IQR) respectively. Of the inmates evaluated, 68.8% reported cough for 2 or more weeks. Other symptoms reported were weight loss (in 40.7%) and night sweats (in 35.8%). Of the 248 inmates evaluated, 95 inmates were tested for HIV and 4.1% were HIV serology positive. Conclusion The prevalence of TB in Mbarara Central prison South Western Uganda is low but calls for continued surveillance through regular TB screening.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Pulmonary Tuberculosis among Prison Inmates at Mbarara Central Prison, South Western Uganda

Owokuhaisa

Thokerunga

Bazira

2014

AIR

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“…In a Taiwanese study; 19.0% of the strains were resistant to INH, 6.1% to RIF, 15.7% to EMB, and 10.0% to STM (21). In a Brazilian study 13.8% of the strains were resistant to INH and 8.6% for STM (22).…”

Section: Discussionmentioning

confidence: 96%

Characterization of Mycobacterium tuberculosis complex isolated from iranian and afghani patients by spoligotyping method

Ramazanzadeh

Farnia

Amirmozafari³

2009

Braz. J. Microbiol.

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Designing newer drugs, vaccines, and diagnostic techniques is dependent on better understanding of M. tuberculosis virulence mechanism. In this study the prevalence of pcaA gene was determined in M. tuberculosis strains typed by spoligotyping. The associated risk factors among patients with different nationalities residing in Iran were also determined. The isolated M. tuberculosis strains have been characterized by performing susceptibility tests against four first-line antituberculosis drugs and were then subjected to spoligotyping characterization. PCR was used for detection of pcaA gene and its nucleotide sequence was also determined. Spoligotyping of M. tuberculosis strains resulted in 140 different patterns. One hundred twenty two (87.1%) of these spoligotype isolates were unique and reported for the first time. The remaining18 (12.8%) spoligotype patterns were previously reported from other geographical regions of the world. Haarlem family was most prevalent than other genotype. Antibiotic resistances were higher in those isolated from the Iranian patients. The pcaA gene was detected in M. tuberculosis clinical isolates but not in saprophyte strains such as M. kansasi. The results showed that, spread of M. tuberculosis strains belonging to the Beijing family among Iranian patients has to be considered seriously. This study confirmed the widespread existence of pcaA gene in almost all the clinical isolates. It is also important to undertake studies to identify which factors are the most significant to consider in tuberculosis control program.

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“…En nuestro trabajo, un alto porcentaje de resistencia a rifampicina solo se encontró en la población antes tratada. Además, entre los hallazgos de este estudio se evidenció que entre el 3,8% y el 8,9% de pacientes TB pulmonar, son resistentes a isoniacida y rifampicina juntas; es decir, La TB MDR, lo cual difiere del 4% de TB MDR en la población general de nuestra región para el mismo periodo de tiempo [23] . Se sabe que en las Américas el 3,5% de casos de TB que se diagnostican son casos de TB MDR y que a través de investigaciones preliminares realizadas en centros penitenciarios de algunos países, la presencia de TB MDR es más alta, debido básicamente al control inadecuado de casos de TB * Total = 245 pacientes, para los demás casos = 130.…”

Section: Discussionunclassified

Características epidemiológicas de tuberculosis pulmonar en establecimiento penitenciario de varones de Trujillo – Perú

Hidalgo

Tuñoque

2017

Acta Med Peru

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Objetivos: Conocer la actual magnitud y perfil de resistencia en los afectados de la tuberculosis del penal de Trujillo. Materiales y métodos: El estudio fue descriptivo observacional. Los datos fueron tomados de informes de la estrategia TB del penal de varones de Trujillo y de los registros del laboratorio referencial de la Gerencia Regional de Salud entre enero 2012 a diciembre 2015. Se analizaron resultados de incidencia, prevalencia y de pruebas de sensibilidad a fármacos antituberculosos. En el análisis estadístico se utilizó medidas de frecuencia simple y cruzada; el test de student y la prueba Z, mediante el programa estadístico IBM SPSS 23.0. Resultados: Se obtuvieron datos de 308 varones con tuberculosis pulmonar; 245 (79,5%) contaban con resultados de pruebas de sensibilidad. El promedio de edad fue de 29,6 ± 8,7 años. En los antes tratados se evidenció altas tasas de resistencia a isoniacida, estreptomicina y rifampicina y en los nunca tratados se evidenció altas tasas de resistencia a isoniacida y estreptomicina. La prevalencia de tuberculosis multidrogo resistente estuvo entre el 3,8% y 8,9 %. Conclusiones: la resistencia a isoniacida fue alta tanto en pacientes con y sin antecedente de tratamiento previo y la tuberculosis pulmonar multirresistente es un problema epidemiológico; pero menor que la resistencia a isoniacida.

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Multidrug-resistant tuberculosis among male inmates in Rio de Janeiro, Brazil

Cited by 6 publications

References 11 publications

Prevalence of Pulmonary Tuberculosis among Prison Inmates at Mbarara Central Prison, South Western Uganda

Prevalence of Pulmonary Tuberculosis among Prison Inmates at Mbarara Central Prison, South Western Uganda

Characterization of Mycobacterium tuberculosis complex isolated from iranian and afghani patients by spoligotyping method

Características epidemiológicas de tuberculosis pulmonar en establecimiento penitenciario de varones de Trujillo – Perú

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