Desenvolvimento de formadores de filmes poliméricos orgânico-inorgânico para liberação controlada de fármacos e tratamento de feridas

Oshiro, João Augusto; Shiota, Leticia Moriya; Chiavacci, Leila Aparecida

doi:10.1590/s1517-70762014000100005

Cited by 5 publications

(9 citation statements)

References 13 publications

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“…Previous studies conducted by our research group revealed that the transport mechanisms involved in control of the drug in Ureasil-PPO400 and Ureasil-PEO500 occur by Fickian diffusion and anomalous transport (where swelling and Fickian diffusion are the transport mechanisms that release the drug from the matrix to the medium), respectively [13,16,26]. Thus, in Ureasil-PPO400 the amount of the drug does not influence the behavior as it does in Ureasil-PEO500.…”

Section: In Vitro Drug Release Assaymentioning

confidence: 79%

“…The ureasil-polyether mucoadhesive films were prepared according to our previously reported protocol [12][13][14]. Briefly, mucoadhesive films were prepared by the sol-gel process, using in the synthesis of precursor a functionalized polyether, based on poly(ethylene oxide) (NH 2 -PEO-NH 2 ) (MW 500 g mol −1 ) or poly (propylene oxide) (NH 2 -PPO-NH 2 ) (MW 400 g mol −1 ), and adding a modified alkoxide, 3-(isocyanatopropyl)-triethoxysilane (IsoTrEOS) (molar ratio of the polymer:alkoxide=1:2).…”

Section: Preparation Of Ureasil-polyether Mucoadhesive Filmsmentioning

confidence: 99%

“…Organic-inorganic hybrid materials whose inorganic phase is formed by silica, a class called ureasil-polyether, in particular, meet some of these important characteristics to act as mucoadhesives, such as mechanical resistance (flexibility), thermal resistance, transparency, the ability to release drugs and chemical groups (-OH, -COOH) in its structure capable of making hydrogen bonds with the oral mucosa. They can be applied to a variety of drugs, are low cost and easy to apply, increasing patients' adherence to therapy [12][13][14][15][16][17]. The macroporous feature allows the presence of compartments in the system, which could represent special molecular encapsulation and release capabilities [18].…”

Section: Introductionmentioning

confidence: 99%

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Study of triamcinolone release and mucoadhesive properties of macroporous hybrid films for oral disease treatment

Oshiro

Nasser

Chiari-Andréo

et al. 2018

Biomed. Phys. Eng. Express

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The aim of this study was to develop macroporous mucoadhesive films from ureasil-polyether materials for future application in oral disease treatment. The films were prepared via the sol-gel route by using polyethylene oxide (PEO) and polypropylene oxide (PPO) polymers; triamcinolone was used as a model drug for in vitro release testing. The in vitro drug release assay revealed that Ureasil-PEO500 films containing 3% and 6% of the model drug released 56% and 33% of the initial mass, respectively. This difference in release is probably due to a higher amount of the drug, making relaxation of polymer chains difficult, causing reduced swelling. For Ureasil-PPO400 films the amount of the drug did not influence the release; the rate of release was 5.1% after 12 hours and this lower release can be explained by the hydrophobic character of Ureasil-PPO400 polymeric chains. These results are in agreement with the swelling results. The swollen behavior of the films was monitored by small-angle x-ray scattering measurements (SAXS). Atomic force microscopy demonstrated that all the films are macroporous (pores around 400 nm) but the Ureasil-PEO500 film possesses more pores than Ureasil-PPO400. Mucoadhesion force assessment revealed that all ureasil-polyether films with or without a model drug have higher mucoadhesion values than the commercial product. These results indicate that macroporous ureasil-polyether mucoadhesive films are promising candidates for oral disease treatment considering their cost, biocompatibility, drug release and ease of handling, and they have more adhesion force to oral mucosa than the commercial product.

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Section: In Vitro Drug Release Assaymentioning

confidence: 79%

Section: Preparation Of Ureasil-polyether Mucoadhesive Filmsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Study of triamcinolone release and mucoadhesive properties of macroporous hybrid films for oral disease treatment

Oshiro

Nasser

Chiari-Andréo

et al. 2018

Biomed. Phys. Eng. Express

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“…The materials can be conventional, interactive, or bioactive. Film-forming materials are an alternative to conventional curative systems and have numerous advantages (JUNIOR et al, 2014;SANTANA, 2015). Among these advantages, films used as wound dressings act as temporary skin substitutes, functioning as a physical barrier, mainly in managing wound infections and working as mechanical protection.…”

Section: Introductionmentioning

confidence: 99%

“…As they are transparent, the films allow visualization of the wound. Thus, film-forming materials represent a very promising alternative to conventional dressing systems (JUNIOR et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Hydroxypropyl methylcellulose-based films incorporated with Ocimum basilicum L. extract for skin wound healing

Schmitt

Jacques

Andrighetti

et al. 2022

CLIUM

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The skin acts as a protective barrier for the body. Significant functional limitations can occur when damaged, such as pain and infections. This study aims to develop hydroxypropyl methylcellulose (HPMC) films incorporated with Ocimum basilicum L. (OB) extract for wound healing. The plant extract was prepared, followed by production and morphological evaluation of the films determining, for example, water vapor transmission, swelling index, solubility, and antioxidant activity. The films were macroscopically homogeneous, transparent, flexible, and resistant, with an average thickness of 157 μm. They also showed high hydrophilicity due to the polarity of the polymer, soluble in aqueous media, with a good degree of swelling (1.254 % for HPMC + OB 15 %) and good permeability to water vapor (1.467% for the control film), with a light decrease after incorporation of the extract. However, adding the extract increased the antioxidant activity significantly, around 50%, compared to the control film. Thus, it proves to be a promising dressing for wound healing due to the good physical characteristics of the polymer, combined with the antioxidant activity of the extract.

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Modulating the hAM/PCL Biocomposite for Expedited Wound Healing: A Chemical-Free Approach for Boosting Regenerative Potential

Pinky,

Sharma,

Arora

et al. 2024

ACS Biomater. Sci. Eng.

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There is an arising need for effective wound dressings that retain the bioactivity of a cellular treatment, but without the high costs and complexities associated with manufacturing, storing, and applying cell-based products. As skin wound recovery is a dynamic and complicated process, a significant obstacle to the healing of skin wounds is the lack of an appropriate wound dressing that can imitate the microenvironment of healthy skin and prevent bacterial infection. It requires the well-orchestrated integration of biological and molecular events. In this study, we have fabricated full-thickness skin graft biocomposite membranes to target fullthickness skin excision wounds. We reinforced human amniotic membrane (hAM) with electrospun polycaprolactone (PCL) to develop composite membranes, namely, PCL/hAM and PCL/hAM/PCL. Composite membranes were compared for physical, biological, and mechanical properties with the native counterpart. PCL/hAM and PCL/hAM/PCL displayed improved stability and delayed degradation, which further synergically improved the rapid wound healing property of hAM, driven primarily by wound closure analysis and histological assessment. Moreover, PCL/hAM displayed a comparable cellular interaction to hAM. On application as a wound dressing, histological analysis demonstrated that hAM and PCL/hAM promoted early epidermis and dermis formation. Studies on in vivo wound healing revealed that although hAM accelerates cell development, the overall wound healing process is similar in PCL/hAM. This finding is further supported by the immunohistochemical analysis of COL-1/COL-3, CD-31, and TGF-β. Overall, this conjugated PCL and hAM-based membrane has considerable potential to be applied in skin wound healing. The facile fabrication of the PCL/hAM composite membrane provided the self-regenerating wound dressing with the desired mechanical strength as an ideal regenerative property for skin tissue regeneration.

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Desenvolvimento de formadores de filmes poliméricos orgânico-inorgânico para liberação controlada de fármacos e tratamento de feridas

Cited by 5 publications

References 13 publications

Study of triamcinolone release and mucoadhesive properties of macroporous hybrid films for oral disease treatment

Study of triamcinolone release and mucoadhesive properties of macroporous hybrid films for oral disease treatment

Hydroxypropyl methylcellulose-based films incorporated with Ocimum basilicum L. extract for skin wound healing

Modulating the hAM/PCL Biocomposite for Expedited Wound Healing: A Chemical-Free Approach for Boosting Regenerative Potential

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