Study of triamcinolone release and mucoadhesive properties of macroporous hybrid films for oral disease treatment

Abstract

The aim of this study was to develop macroporous mucoadhesive films from ureasil-polyether materials for future application in oral disease treatment. The films were prepared via the sol-gel route by using polyethylene oxide (PEO) and polypropylene oxide (PPO) polymers; triamcinolone was used as a model drug for in vitro release testing. The in vitro drug release assay revealed that Ureasil-PEO500 films containing 3% and 6% of the model drug released 56% and 33% of the initial mass, respectively. This difference in release is probably due to a higher amount of the drug, making relaxation of polymer chains difficult, causing reduced swelling. For Ureasil-PPO400 films the amount of the drug did not influence the release; the rate of release was 5.1% after 12 hours and this lower release can be explained by the hydrophobic character of Ureasil-PPO400 polymeric chains. These results are in agreement with the swelling results. The swollen behavior of the films was monitored by small-angle x-ray scattering measurements (SAXS). Atomic force microscopy demonstrated that all the films are macroporous (pores around 400 nm) but the Ureasil-PEO500 film possesses more pores than Ureasil-PPO400. Mucoadhesion force assessment revealed that all ureasil-polyether films with or without a model drug have higher mucoadhesion values than the commercial product. These results indicate that macroporous ureasil-polyether mucoadhesive films are promising candidates for oral disease treatment considering their cost, biocompatibility, drug release and ease of handling, and they have more adhesion force to oral mucosa than the commercial product.

Nanostructural Arrangements and Surface Morphology on Ureasil-Polyether Films Loaded with Dexamethasone Acetate

“…The pores favor the penetration of water into the matrix, leading to swelling, and thus modifying the surface morphology. The presence of pores helps to explain the higher drug release rates in u-PEO than in u-PPO films [ 31 ].…”

In vivo effectiveness of hybrid membranes with osteogenic growth peptide for bone regeneration

“…Ureasil‐PPO400/PEO1900 membrane released a greater amount of CF‐OGP than ureasil‐PPO400/PEO500. The release results can be explained by two factors: the first relates to the hydrophilic/hydrophobic characteristics of the hybrid polymers and the second to the size of the molecular chain (Oshiro et al., 2018; Souza et al., 2013). The membranes used in this study are based on blends of a low molecular weight hydrophobic polymer (PPO400) with hydrophilic polymers.…”

“…In this context, the Poly (ethylene oxide) or Poly (propylene oxide), linked by urea bridges to a silicate backbone called of ureasil‐polyether (ureasil‐PEO or Ureasil‐POE) is a promising alternative for the development of new membranes due to properties, high flexibility, thermal resistance, mechanical strength, and ability to control the release profile of various substances (lipophilic, hydrophilic, and metals; Molina et al., 2010; Moura et al., 2015; Oshiro et al., 2018).…”

Curcumin-Loaded Micelles Dispersed in Ureasil-Polyether Materials for a Novel Sustained-Release Formulation

“…The films composed of the U-PEO are formed by the sol-gel process, which involves hydrolysis and condensation reactions. The speed of these reactions (film formation time) is controlled by the variation of the precursor/catalyst ratio [ 38 , 39 , 40 , 41 ].…”

“…The organic phase provides specific physical or chemical properties (optical, electrical, reactivity), while the inorganic phase increases mechanical resistance, thermal stability and allows modulation of the refractive index. In addition, the rheological properties favor the processing of the final material with the possibility of varying shapes and sizes [ 38 , 39 , 40 , 41 ].…”