Estudo da degradação "in vivo" de poli(L-co-D,L-ácido láctico) aplicado como prótese para regeneração nervosa periférica

Baraúna, Grazielle S.; Pierucci, Amauri; Oliveira, Alexandre de; Duarte, Marcia Adriana Tomaz; Duek, Eliana A. R.

doi:10.1590/s1517-70762007000200008

Cited by 8 publications

(10 citation statements)

References 20 publications

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“…Among bioresorbable polymers of interest is the copolymer poly (L,co-D,L-lactic acid; PLDLA) that is widely used in the proportion 70:30 because of its good mechanical properties and excellent biocompatibility. This polymer has been the subject of study of this research group and its synthesis is already consolidated so that the polymer has high molecular weight [7][8][9][10][11][12][13][14] . Though PLA is limited by its inherent brittleness, its properties can be significantly enhanced and broadened by modification via copolymerization, which provides a number of advantages because the architecture and composition of the biomaterials can be tailored to control and composition of the biomaterials can be tailored to control the material properties (by anionic or coordinated polymerization) 15 .…”

Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of a novel terpolymer based on L-lactide, D,L-lactide and trimethylene carbonate

Motta

Duek

2014

Mat. Res.

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Terpolymers of L-lactide, D,L-lactide and trimethylene carbonate (TMC) were synthesized via the ring-opening polymerization reaction for cyclic monomers using stannous octoate as the initiator at a ratio of ~0.05 mol% (monomers/(SnOct) 2 ). Synthesis was done at 130 °C for 48 h. The inclusion of TMC, an aliphatic elastomeric polycarbonate, alongside polymer chain segments containing L-lactide and D,L-lactide, was expected to yield a material with improved properties such as increased elongation; this would overcome the limitation of copolymers consisting entirely of lactide and D,L-lactide. The terpolymer properties were assessed by Nuclear magnetic resonance spectroscopy 1 H and 13 C NMR, infrared spectroscopy, differential scanning calorimetry and thermogravimetry, with particular attention being given to the effect of TMC on the copolymer of L-lactide-co-D,L-lactide. The mixing of these polymers resulted in material with a high molar mass (10 5 g/mol). The mechanical properties of the terpolymer were assessed using pins of this material that were tested by mechanical flexion at three points. When compared with results for the copolymer PLDLA there was a decrease in Young's modulus for the TMC-containing terpolymer.

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Section: Introductionmentioning

confidence: 99%

Synthesis and characterization of a novel terpolymer based on L-lactide, D,L-lactide and trimethylene carbonate

Motta

Duek

2014

Mat. Res.

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“…In this way, biomaterials have been tested for physical and mechanical properties that can be more appropriate for application in the human body, for example as surgical suture, systems for controlled release of drugs, artificial skin, artificial veins and blood vessels, orthopedic devices and guides for nervous regeneration with no side effects 1,2 . Poly α-hydroxy acids are thermoplastic poly α-esters with chemical versatility and can be easily customized into desired shapes by molding, extrusion, or solvent processing.…”

Section: Introductionmentioning

confidence: 99%

In vitro degradation of Poly-L-co-D, L-lactic acid membranes

2012

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Poly-L-co-D.L-lactic (PLDLA) is a bioresorbable polymer whose properties have been studied for degradation sensitivity and its application in medicine. In this study, the potential of PLDLA membranes for temporary implantation was evaluated. PLDLA membranes were prepared with the solvent evaporation technique and characterized by differential scanning calorimetry, gel permeation chromatography, thermogravimetric analysis, scanning electron microscopy and traction tests. The glass transition temperature of the membranes was 59 °C. Degradation started around 340 °C during the second week showing pores and fissures on the broken surface. Evident degradation was observed after 16 weeks. Microscopy showed that before degradation PLDLA membranes presented no pores. PLDLA properties of resistance to traction and elasticity module were maintained until the 8 th week, and after the 16 th week there was a sharp reduction of these properties due to degradation. PLDLA membranes present excellent potential as temporary implantation given their degradation characteristics.

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“…PLDLA copolymer is compatible with 34 and suitable for use as a bone graft substitute [35][36][37][38] , meniscus replacement 39,40 , suture cords/threads 41 and axon regeneration 42 . Cellular adhesion to biomaterials is extremely important in material sciences.…”

Section: Discussionmentioning

confidence: 99%

Lithograph-moulded poly-L-co-D,L lactide porous membranes for osteoblastic culture

et al. 2013

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Pore size, shape, wall morphology, porosity, and interconnectivity are important characteristics of the scaffolds. Lithography is a manufacturing technique that allows the production of tridimensional scaffolds with a controllable and reproducible inner architecture. The aim of this study was to use lithography to create a poly-L-co-D,L lactide (PLDLA) scaffold with symmetrical pore size and distribution, and to evaluate its biocompatibility with osteoblasts in vitro. Lithographic moulds were used to produce porous PLDLA membranes by a casting procedure. Osteoblasts were removed from calvarial bones and seeded onto porous and smooth PLDLA membranes after which cell viability and adhesion assays, cytochemical analysis and scanning electron microscopy were used to characterize the cells. Cell viability and adhesion assays, cytochemical analysis, and scanning electron microscopy were carried out. Cell viability was similar on porous and smooth PLDLA membranes but higher than on a polystyrene substrate (positive control). Although osteoblasts adhered to the surface of all the materials tested, cell adhesion to lithographed PLDLA was greater than to smooth PLDLA membranes. In conclusion, osteoblasts interacted well with PLDLA membranes, as shown by the viability and adhesion assays and by the enhanced collagen production.

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Estudo da degradação "in vivo" de poli(L-co-D,L-ácido láctico) aplicado como prótese para regeneração nervosa periférica

Cited by 8 publications

References 20 publications

Synthesis and characterization of a novel terpolymer based on L-lactide, D,L-lactide and trimethylene carbonate

Synthesis and characterization of a novel terpolymer based on L-lactide, D,L-lactide and trimethylene carbonate

In vitro degradation of Poly-L-co-D, L-lactic acid membranes

Lithograph-moulded poly-L-co-D,L lactide porous membranes for osteoblastic culture

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