Reproductive performance and embriotoxicity of rats exposed to carbamazepine

Gerenutti, Marli; Oliveira, Carolina Clavijos de; Miranda, Aliana Conceição Ribeiro de; Rosa, Raquel Mendonça; Fiol, Fernando de Sá Del

doi:10.1590/s1516-93322008000300022

Cited by 7 publications

(3 citation statements)

References 24 publications

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“…In the present work, PGB induced growth retardation was represented by a decrease in fetal body weight of offspring of PGB treated females by a dose of 1250 mg/kg. The mechanism of drug toxicity during the pregnancy depends on the reproductive performance of the mother and drug dose [20]. The corpus luteum has a significant function in the reproductive implementation, as it is able to produce critical hormones, progesterone,and 20-hydroxy progesterone, which keep the fetus growing.…”

Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study

Ismail

Shaltout

Abdellah

et al. 2022

BMC Pharmacol Toxicol

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Background Pregabalin (PGB) was approved as new anti-epileptic drugs with little information about its teratogenic effect. Aim of the work to evaluate the developmental toxicity of PGB. Materials and methods 60 pregnant albino rats were divided into three groups. PGB (500 mg/kg body weight/day) was given to group II, PGB (1250 mg/kg body weight/day) was given to Group III and no medications were given to group I. The pups were normally delivered. Liver, kidney and heart specimens were prepared for histological, immunohistochemical, and morphometric studies. Results A dose of 500 mg of PGB had minimal toxic effects in the form of mild collagen deposition and moderate positive caspase-3 immunoexpression. PGB dose of 1250 mg/kg induced gross toxic effects in form of degenerated cardiac myofibres, ruptured blood vessels, vacuolations in the renal cortex, fibrosis and strong positive caspase-3 immunoexpression. Conclusion PGB at dose of 500 mg/kg revealed minimal toxic changes. PGB cause embryotoxicity in a dose-dependent manner, as the higher dose induced more degenerative changes.

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Section: Discussionmentioning

confidence: 99%

RETRACTED ARTICLE: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study

Ismail

Shaltout

Abdellah

et al. 2022

BMC Pharmacol Toxicol

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“…The mechanism of drug toxicity during pregnancy is determined by the mother's reproductive efficiency and the dose of the drug. [ 35,36 ]…”

Section: Discussionmentioning

confidence: 99%

Impact of maternal desvenlafaxine exposure on brain development in pregnant albino rats and their fetuses

Ahmed

Ghareeb

El‐Rahman

et al. 2022

J Biochem & Molecular Tox

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Depression during pregnancy adversely affects fetal development. Desvenlafaxine drug is used for the treatment of gestational depression. In light of the well‐established role of brain‐derived neurotrophic factor (BDNF) and nerve growth factor (NGF) in regulating neurogenesis and neural survival, the role of S100b in nerve cell energetic metabolism, differentiation of neurons and glial cells, an aberrant increase in NGF, BDNF and S100b expression in the fetal brain may contribute to desvenlafaxine cognitive disorders by altering brain development. This study is trying to determine the effect of desvenlafaxine on brain development. Thirty timed pregnant rats (from the 5th to the 20th day) were divided into three groups: control, low dose (5.14 mg/kg/day) and high dose (10.28 mg/kg/day) of desvenlafaxine where all animals received the corresponding doses by gavage. Maternal and fetal brain samples were fixed for histological, immunohistochemical (IHC) study of NGF and evaluated for BDNF and S100b genes expression. Desvenlafaxine induced some of the histopathological alterations in maternal and fetal rat brains. Moreover, IHC analysis of maternal and fetal rat brains showed that groups treated with desvenlafaxine demonstrated a significant increase of NGF protein immunoreactivity compared with that in the controls. Gene expression results revealed upregulation of messenger RNA BDNF and S100B expression. According to developmental changes in the brain, desvenlafaxine affects neonatal growth during pregnancy, which may lead to delay of brain development. So, it is essential to survey the roles of antidepressant drugs on neonatal development during pregnancy.

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“…Although a substance does not have harmful effects on motherhood, it can still affect fertility. Fertility (ability to have children) is determined by the number of implantations, pre-and post-implantation losses and litter (Gerenutti et al, 2008). During implantation, the embryo can either continue its normal development or be reabsorbed (Van Mourik et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Maternal-fetal repercussions of Angylocalyx oligophyllus leaves aqueous extract in pregnant rat

Tenezogang¹,

Tchamadeu²,

Bogning³

et al. 2022

Afr. J. Pharm. Pharmacol.

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Angylocalyx oligophyllus (Fabaceae) is a shrub used traditionally to treat diabetes mellitus and intestinal parasites. Although it is also used by pregnant women, no scientific study has yet revealed its effects on pregnancy. This work aimed to assess the toxic effects of A. oligophyllus leaves aqueous extract on pregnancy, reproduction and fetal development in pregnant rats. The acute toxicity of the A. oligophyllus leaves aqueous extract was firstly performed in female non-pregnant rats. Then, pregnant rats were divided into a control and three test groups receiving, respectively distilled water and A. oligophyllus leaves aqueous extract doses (50, 100 and 200 mg/kg) by gavage for 20 days (from pregnancy screening day). The daily body masses of pregnant rats and the 21st-day relative organs masses were measured for assessing the pregnancy progress. The numbers of corpora lutea, implantation sites, live and dead fetuses and calculated pre-and-post implantation loss for appreciating the reproduction, and the fetuses' masses for fetal development assessment, were recorded on the 21st day. Acute administration of the A. oligophyllus leaves aqueous extract (2000 mg/kg) did not cause any death or adverse effect in non-pregnant female rats. The LD 50 was estimated higher than 2000 mg/kg. Pregnancy and reproductive parameters did not vary significantly between plant extracttreated rats and control. However, although fetal development parameters did not change significantly between the groups, the percentages of small (SGA) and large (LGA) pups for the gestational age were higher in rats treated with the dose extract of 200 mg/kg, compared to control (20 and 11%, respectively). Current data showed that the A. oligophyllus leaves aqueous extract does not impair motherhood and reproduction. Nevertheless, limitation of the dose is recommended during treatment in pregnant women to avoid adverse effect on fetal development.

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Reproductive performance and embriotoxicity of rats exposed to carbamazepine

Abstract: To study the possible effects of carbamazepine in rats during pregnancy and fetuses´ physical development, carbamazepine solubilized in propilenglycol was orally administered (20 and 40 mg/kg)

Cited by 7 publications

References 24 publications

RETRACTED ARTICLE: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study

RETRACTED ARTICLE: The teratogenic effect of pregabalin on heart, liver and kidney in rats: a light microscopic, electron microscopic and immunohistochemical study

Impact of maternal desvenlafaxine exposure on brain development in pregnant albino rats and their fetuses

Maternal-fetal repercussions of Angylocalyx oligophyllus leaves aqueous extract in pregnant rat

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