Quantitative determination of ciprofloxacin and norfloxacin in pharmaceutical preparations by high performance liquid chromatography

Kassab, Nájla Mohamad; Singh, Anil Kumar; Kedor-Hackmam, Erika R.M.; Santoro, María Inés Rocha Miritello

doi:10.1590/s1516-93322005000400014

Cited by 29 publications

(20 citation statements)

References 27 publications

(27 reference statements)

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“… for ciprofloxacin and streptomycin: water with 2 mL of orthophosphoric acid (pH = 3.3) and acetonitrile (80:20) [25][26][27][28][29].…”

Section: Experimental Procedures and Apparatusmentioning

confidence: 99%

Degradation of Antibiotics in Aqueous Solution by Photocatalytic Process: Comparing the Efficiency in the Use of ZnO or TiO2

Ambrosetti¹,

Campanella²,

Palmisano³

2015

JESE-A

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Abstract:The study examined the photodegradative efficiency of ZnO and TiO 2 in degradation of antibiotics in aqueous matrices. Among several types of antibiotics, four antibiotics were chosen to feature the major classes of these compounds: amoxicillin, erythromycin, streptomycin and ciprofloxacin. Degradation of antibiotic solutions was carried out mainly under UV-light irradiation in a set time with the presence of small quantity of zinc oxide or titanium dioxide. Solutions were analyzed with HPLC chromatography and degradation percentages were calculated from ratio between pick area associated to no degraded drug solution and degraded drug solution's pick area. Meanwhile, toxicity of antibiotics and degrading compounds were investigated using a biosensor system, consisting of Clark's electrode associated with a portion of agar medium culture containing Saccharomyces Cerevisiae yeast cells. This way, it was possible to define the oxygen that was consumed by yeast cells. Toxicity associated to antibiotics and degrading products are related to decrease of oxygen concentration in solution. It is clear that zinc oxide is slower than titanium dioxide to degrade antibiotics, but zinc oxide shows better photodegradation efficiency than titanium dioxide in spite of its small specific superficial area.

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“… for ciprofloxacin and streptomycin: water with 2 mL of orthophosphoric acid (pH = 3.3) and acetonitrile (80:20) [25][26][27][28][29].…”

Section: Experimental Procedures and Apparatusmentioning

confidence: 99%

Degradation of Antibiotics in Aqueous Solution by Photocatalytic Process: Comparing the Efficiency in the Use of ZnO or TiO2

Ambrosetti¹,

Campanella²,

Palmisano³

2015

JESE-A

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“…In addition to the analytical methods discussed in the preceding text, several other methods [76][77][78][79][80][81] have been reported by researchers which provide relevant scientific information for determination of ciprofloxacin.…”

Section: +mentioning

confidence: 99%

Ciprofloxacin: review on developments in synthetic, analytical, and medicinal aspects

Sharma

Jain

et al. 2010

Journal of Enzyme Inhibition and Medicinal Chemistry

224

130

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“…These include the classical microbiological methods (Cabello, 2004;Park et al, 2007) that have the disadvantage of taking too long to produce an analytical result and being subject to biological variability. Separative methods based in liquid-chromatographic techniques coupled to mass-spectrometry (Kassab et al, 2005;Dufresne et al, 2007), fluorescence (Zhang et al, 2007;Chui-Shiang et al, 2008) and/or a combination of these (Schneider et al, 2005), and electrophoresis (McCourt et al, 2003) have also been used. These are great in terms of accuracy and robustness, but unable to carry out on-site analysis.…”

Section: Introductionmentioning

confidence: 99%

Novel optical PVC probes for on-site detection/determination of fluoroquinolones in a solid/liquid interface: Application to the determination of Norfloxacin in aquaculture water

Silva

Moreira

Truta

et al. 2012

Biosensors and Bioelectronics

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A novel optical disposable probe for screening fluoroquinolones in fish farming waters is presented, having Norfloxacin (NFX) as target compound. The colorimetric reaction takes place in the solid/liquid interface consisting of a plasticized PVC layer carrying the colorimetric reagent and the sample solution. NFX solutions dropped on top of this solid-sensory surface provided a colour change from light yellow to dark orange.Several metals were tested as colorimetric reagents and Fe(III) was selected. The main parameters affecting the obtained colour were assessed and optimised in both liquid and solid phases. The corresponding studies were conducted by visible spectrophotometry and digital image acquisition. The three coordinates of the HSL model system of the collected image (Hue, Saturation and Lightness) were obtained by simple image management (enabled in any computer).The analytical response of the optimised solid-state optical probe against concentration was tested for several mathematical transformations of the colour coordinates. Linear behaviour was observed for logarithm NFX concentration against Hue þ Lightness. Under this condition, the sensor exhibited a limit of detection below 50 mM (corresponding to about 16 mg/mL). Visual inspection also enabled semi-quantitative information. The selectivity was ensured against drugs from other chemical groups than fluoroquinolones.Finally, similar procedure was used to prepare an array of sensors for NFX, consisting on different metal species. Cu(II), Mn(II) and aluminon were selected for this purpose. The sensor array was used to detect NFX in aquaculture water, without any prior sample manipulation.

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Quantitative determination of ciprofloxacin and norfloxacin in pharmaceutical preparations by high performance liquid chromatography

Cited by 29 publications

References 27 publications

Degradation of Antibiotics in Aqueous Solution by Photocatalytic Process: Comparing the Efficiency in the Use of ZnO or TiO2

Degradation of Antibiotics in Aqueous Solution by Photocatalytic Process: Comparing the Efficiency in the Use of ZnO or TiO2

Ciprofloxacin: review on developments in synthetic, analytical, and medicinal aspects

Novel optical PVC probes for on-site detection/determination of fluoroquinolones in a solid/liquid interface: Application to the determination of Norfloxacin in aquaculture water

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