Administração oral de peptídeos e proteínas: II. Aplicação de métodos de microencapsulação

Silva, Catarina; Ribeiro, António; Ferreira, Domingos; Veiga, Francisco

doi:10.1590/s1516-93322003000100002

Cited by 45 publications

(51 citation statements)

References 95 publications

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“…Microspheres may be homogeneous or heterogeneous depending on whether the core is in the molecular state (dissolved) or in the form of particles (suspended), respectively (SILVA et al, 2003).…”

Section: Capsulementioning

confidence: 99%

Microencapsulation: concepts, mechanisms, methods and some applications in food technology

et al. 2014

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Section: Capsulementioning

confidence: 99%

Microencapsulation: concepts, mechanisms, methods and some applications in food technology

et al. 2014

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“…The degradation tests demonstrated that the hydrogel could maintain the gel matrix over 35 days, depending on the ADH concentration, while inducing low inlammation and dense blood vessel formation in the areas surrounding the implanted hydrogels [105,106]. Hyaluronan-mediated angiogenic efect in vivo is related to its degradation products, which stimulate endothelial cell proliferation and migration [102,107]. Consequently, hyaluronan plays important roles in maintaining tissue morphologic organization, preserving extracellular space and transporting ions, solutes and nutrients.…”

Section: Lim Et Al Related That Their Results On Poly(l-lactic Acid)mentioning

confidence: 99%

Three-Dimensional and Biomimetic Technology in Cardiac Injury After Myocardial Infarction: Effect of Acellular Devices on Ventricular Function and Cardiac Remodelling

Chaud¹,

Alves²,

Rebelo³

et al. 2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Dilated cardiomyopathy (DMC) of ischemic or non-ischemic aetiology remains a lethal condition nowadays. Despite early percutaneous or medical revascularization after an acute myocardial infarct (AMI), many patients still develop DMC and severe heart failure due to cardiac remodelling. Possibility of regenerating myocardium already damaged or at least inducing a more positive cardiac remodelling with use of biodegradable scafolds has been atempted in many experimental studies, which can be cellular or acellular. In the cellular scafolds, the cells are incorporated in the structure prior to implantation of the same into the injured tissue. Acellular scafolds, in turn, are composites that use one or more biomaterials present in the extracellular matrix (ECM), such as proteoglycans non-proteoglycan polysaccharide, proteins and glycoproteins to stimulate the chemotaxis of cellular/molecular complexes as growth factors to initiate speciic regeneration. For the development of scafold, the choice of biomaterials to be used must meet speciic biological, chemical and architectural requirements like ECM of the tissue of interest. In acute myocardial infarction, treating the root of the problem by repairing injured tissue is more beneicial to the patient. Inducing more constructive forms of endogenous repair. Thus, patches of acellular scafolds capable of mimicking the epicardium and ECM should be able to atenuate both cardiac remodelling and adverse cardiac dysfunction.

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“…[57] O método da coacervação apresenta algumas vantagens em relação aos outros métodos, principalmente quando se trata do encapsulamento de fármacos hidrossolúveis, onde ela apresenta elevados rendimentos de encapsulação. [57] Esse procedimento é empregado largamente também na indústria alimentícia, onde o processo é frequentemente empregado no encapsulamento de óleos vegetais e animais, vitaminas e nutrientes, prevenindo, por exemplo, a degradação e/ou oxidação destes componentes.…”

Section: Coacervaçãounclassified

“…Ou seja, essa alteração do meio resultou na dessolvatação das moléculas do polímero promovendo as interações polímero-polímero em detrimento das interações polímero-solvente. [57,58] Vale ressaltar que o Fs utilizado para os estudos iniciais de encapsulamento foi a porfirina 3MMe.…”

Section: Encapsulamento Dos Derivados Porfirínicosunclassified

Derivados porfirínicos nanoencapsulados como fotossensibilizadores em terapia fotodinâmica

Nogueira¹

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2011Aos meus pais Olívio e Maria pelo amor, carinho e proteção. Por terem me apoiado e compreendido que a distância era necessária para que eu alcançasse meus ideais. Ao meu esposo Thiago pelo amor, carinho, apoio e incentivo em todos os momentos, e por tornar cada segundo do meu dia especial. AGRADECIMENTOSA Deus, por tudo que consegui e por cuidar sempre de mim e de todos que amo.Ao meu irmão Maycon, pelo amor, apoio e incentivo.Ao Prof. Koiti Araki, pela orientação, paciência, amizade e por contribuir para o meu crescimento científico.Ao Prof. Maurício Baptista, pela amizade e por abrir as portas de seu laboratório e colaborar intensamente para o desenvolvimento desse trabalho.Às "florzinhas" Aline, Michele e Rebeca pela amizade, festinhas e tricôs.Aos amigos Paulo e Luix pelas conversas, discussões e boas risadas.Àos amigos Adjaci, Christiane e Helena pela amizade, colaboração e pelas discussões que contribuíram muito para o desenvolvimento desse trabalho.À amiga Thati Feher pelo treinamento e auxílio na sala de cultura.À amiga Roberta pela ajuda e companhia nos longos experimentos no biotério.Ao amigo Eduardo Caritá pelas discussões e grandes contribuições para a realização deste trabalho.Ao prof. Henrique E. Toma e aos colegas do LQSN pela agradável convivência e troca de conhecimentos e experiências ao longo desses anos. Aos colegas do LPFI pelos cafézinhos e momentos de descontração (dancinhas).Aos amigos e funcionários da SPG, Cibele, Milton, Emiliano, Marcelo e Paulo pela atenção e inúmeros serviços prestados durante esses anos.Às amigas Renata e Vanessa por estarem sempre presentes, pelo apoio, carinho e amizade.Ao CNPq e a FAPESP, pela bolsa e pelos auxílios concedidos. A series of eight monocationic porphyrins derivatives as free-base and Zn(II) complexes, with methyl or [Ru(bipy) 2 Cl] + groups bond to the nitrogen atom of the meso-pyridyl substituent, were synthesized and characterized aiming their application as photosensitizers in the treatment of skin tumors by Photodynamic Therapy (PDT). Those compounds, especially the methylated derivatives of the free-base porphyrins, are potentially useful because showed higher quantum yields for the photoinduced formation of singlet oxygen and amphiphilic character, that enhanced their interaction with biological membranes. The low solubility in aqueous media, a limiting factor for use as photosensitizers, was overcome by encapsulating them in polymeric micro-and nanocapsules using the coacervation method. Two formulations, one based on hydroxyethyl cellulose (HEC) and another in the marine atelocollagen/xanthan gum (MAC) mixture were prepared and their photodynamic efficiencies and cytotoxicity against HeLa cells determined. The MAC formulations were shown to be non-toxic, while the HEC presented a small but significant cytotoxicity in the dark. On the other hand, all formulations become toxic when irradiated with 650 nm laser or white light from a mercury lamp source. The most actives, among all formulations, were those prepared using the methylated fre...

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Administração oral de peptídeos e proteínas: II. Aplicação de métodos de microencapsulação

Cited by 45 publications

References 95 publications

Microencapsulation: concepts, mechanisms, methods and some applications in food technology

Microencapsulation: concepts, mechanisms, methods and some applications in food technology

Three-Dimensional and Biomimetic Technology in Cardiac Injury After Myocardial Infarction: Effect of Acellular Devices on Ventricular Function and Cardiac Remodelling

Derivados porfirínicos nanoencapsulados como fotossensibilizadores em terapia fotodinâmica

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