Microencapsulation of a Colombian Spodoptera frugiperdaNucleopolyhedrovirus with Eudragit® S100 by spray drying

Kurmen, Judith Elena Camacho; Álvarez, Martha Isabel Gómez; Villamizar, Laura

doi:10.1590/s1516-8913201500453

Cited by 8 publications

(5 citation statements)

References 26 publications

(28 reference statements)

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“…The preservation of spherical shape of DSP/CB and DSP/CB-HAp capsules was also achieved by reinforcing of alginate with mineral fillers. Some folds and cavities were observed, as an evidence of unavoidable contraction force and polymer viscosity increase during any drying process [34]. The rough surface of DSP/CB and DSP/CB-HAp demonstrates the presence and even distribution of mineral fillers.…”

Section: Resultsmentioning

confidence: 99%

Alginate Capsules with Cuttlebone-derived Fillers as an Integrated Solution for Bone Repair

Palaveniene

Lebedevaite

Liesienė

2018

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Alginate capsules with cuttlebone-derived fillers were developed for bone repair applications. Prepared capsules were designed to be suitable for the treatment of small-sized bone loss provocative diseases, such as endodontic and periodontal diseases. Cuttlebone microparticles, as a source of calcium carbonate, or cuttlebone-derived hydroxyapatite microparticles were used as mineral fillers for the preparation of alginate capsules. The capsules were additionally covered with chitosan layer for the hard structure formation and improvement of adhesive properties. Encapsulation efficiency of dexamethasone as a model allopathic drug was 19 %, 24 % and 12 % for capsules with cuttlebone microparticles, capsules with cuttlebonederived hydroxyapatite and capsules without any mineral filler (control group), respectively. We observed that chitosan coating and lyophilisation contributed for the preservation of spherical structure of alginate capsules with mineral fillers. Swelling study of dried capsules in simulated physiological environment (in phosphate buffer saline, pH = 7.2 at 37 °C temperature) showed that average swelling index of alginate-based capsules without mineral fillers was much higher in comparison to capsules with cuttlebone fillers: 121 %, 17 % and 3 % for control group, capsules with cuttlebone microparticles and capsules with cuttlebone-derived hydroxyapatite, respectively.

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Section: Resultsmentioning

confidence: 99%

Alginate Capsules with Cuttlebone-derived Fillers as an Integrated Solution for Bone Repair

Palaveniene

Lebedevaite

Liesienė

2018

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“…Experiments demonstrated that AfMNPV in lignin-based spray-dried formulations had a shelf-life of up to 3 months at 30°C and up to 30 months at 4°C, and with longer residual insecticidal activity in the field compared to unformulated or a glycerin formulation. Camacho et al (2015) improved virus survival in ultraviolet light by preparing microcapsules of the virus with Polyacrylic acid resin, but because of its emulsification, the cost of microencapsulation is too high due to the pollution of oil phase and the complicated impurity removal process.…”

Section: Discussionmentioning

confidence: 99%

“…It loses the significance of keeping a protective UV coating on the virus after spray application. Camacho et al (2015) sprayed drying Eudragit® S100 as a polymer coating to protect viral particles of UVinactivation. Due to the emulsification method, the pollution of a large amount of oil phase during the preparation process and the complicated impurity removal process make the microcapsule process cost too high (Yan et al, 2020).…”

Section: Introductionmentioning

confidence: 99%

Preparation and performance of insect virus microcapsules

Luo

Zhu

Lin

et al. 2021

Egypt J Biol Pest Control

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Background Biological pesticides, especially baculovirus, often lose their activity under the influence of external light, temperature, and other changes. This limited the application of them. The present study was aimed to prolong the biological activity and ensure the efficacy of a biological pesticide using microencapsulation technology. Results In this study, gelatin/carboxymethylcellulose (CMC)-Spodoptera litura nucleopolyhedrovirus microcapsules were prepared. The morphological characteristics, apparent morphology, embedding rate, virus loading, particle size, laboratory virulence, and UV resistance of the microencapsulated virus, were tested. The best conditions for preparing gelatin /CMC-S. litura nucleopolyhedrovirus microcapsules include the gelatin/CMC ratio of 9:1, wall material concentration of 1%, core material/wall ration ratio of 1:2, re-condensation pH of 4.67, and curing time of 1 h. The prepared microcapsules of S. litura nucleopolyhedrovirus exhibited a good external appearance and spherical shapes with an average particle size of 13 μm, an embedding rate of 62.53%, and a drug loading of 43.87%. The virulence test showed that the microencapsulated virus lost by 2.21 times of its initial activity than the untreated virus. After being treated with field exposure, the gelatin/CMC shell of the microcapsule can better protect the virus in the wild environment. Conclusion Microencapsulation improves the tolerance of S. litura nuclear polyhedrosis virus to ultraviolet radiation. These results will provide ideas for the research of stable and efficient baculovirus preparations and further promote the application and promotion of environmental friendly biological pesticides.

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“…• Yield (%): the product recovered from each batch was weighed (PCR, Torrey ® , Mexico) and the value was divided among the theoretical weight of the finished product (3.54 kg) to calculate the yield, expressed as a percentage (Camacho et al 2015).…”

Section: Finished Product Characterizationmentioning

confidence: 99%

“…In Colombia, a biopesticide prototype formulated as a wettable powder was developed based on the ErelGV VG010 with mortalities higher than 80% on second and fourth instar larvae (Cuartas et al, 2018). Considering that this biopesticide must be applied on the foliage, the formulation was designed to protect the virus from deleterious conditions that could affect its effectiveness, such as environmental factors (i.e., precipitation, relative humidity, UV radiation, and temperature) (Villamizar et al, 2010;Camacho et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Formulation process of a biopesticide based on the Erinnyis ello betabaculovirus ErelGV: unit operations analysis

Quiroga-Cubides¹,

Agropecuaría²,

Toloza-Moreno³

et al. 2021

RMIQ

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Microencapsulation of a Colombian Spodoptera frugiperdaNucleopolyhedrovirus with Eudragit® S100 by spray drying

Abstract: A Colombian Spodoptera frugiperda nucleopolyhedrovirus NPV003 with high potential for the development of an efficient biopesticide was microencapsulated by spray drying with a pH dependent polymer (Eudragit® S100

Cited by 8 publications

References 26 publications

Alginate Capsules with Cuttlebone-derived Fillers as an Integrated Solution for Bone Repair

Alginate Capsules with Cuttlebone-derived Fillers as an Integrated Solution for Bone Repair

Preparation and performance of insect virus microcapsules

Formulation process of a biopesticide based on the Erinnyis ello betabaculovirus ErelGV: unit operations analysis

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