Bark Extract of Bathysa cuspidata in the Treatment of Liver Injury Induced by Carbon Tetrachloride in Rats

Abstract

The aim of this study was to investigate the effect of bark extract Bathysa cuspidata (BCE) in the reconstitution

Functional Assessments and Histopathology of Hepatorenal Tissues of Wistar Rats Infused with Carbon Tetrachloride and Treated with Raw and Hydrothermal Processed Herbs

“…13,77,94,95 The present findings showed that the capacities of the raw and hydrothermal processed herbs to reverse elevated levels of serum AST and ALT activities were comparable with that of silymarin, which was used as reference treatment of fibrotic rats. Furthermore, it appeared that the raw herbs exhibited greater capacities to lower serum ALT activities of fibrotic rats than those of corresponding hydrothermal processed herbs, which was an indication of greater capacities of the raw herbs to ameliorate CCl 4 -induced liver injury than those of corresponding hydrothermal processed herbs.…”

“…5,6,7,8,9 Carbon tetrachloride (CCl 4 ) is a chemical agent noted to be toxic to hepatorenal tissues in experimental animals and human subjects. 5,6,8,10,11,12,13 Reports showed that CCl 4 toxicity is elicited by microsomal CYP2E1-induced formation of reactive trichloromethyl (CCl 3…”

“…1,9,11,12,13,14 Herbal extracts have been reported to ameliorate hepatic and renal disorders in humans and animal models. 2,9,13,15 There is a vast array of Nigerian indigenous medicinal plants that are used for the treatment and management of pathologic conditions linked with overwhelming levels of reactive metabolic radicals. 16,17 Monodora myristica, also called calabash Nutmeg, is an edible plant of the Annonaceae family.…”

“…32,33 Furthermore, Ndidi et al 34 reported the proximate, antinutrients and mineral composition of raw and processed African yam bean. Studies have shown that CCl 4 infusion or inhalation elicits chemical-induced multiple organ lesions such as fibrosis, cirrhosis and hepatocarcinoma, 12,13,35,36 and by extension, renal dysfunction in animal models. 5,6,12 Organ lesion and ensuing pathology elicit wide variations in concentrations of metabolites and elevation of non-functional plasma enzymes in blood samples of experimental animals.…”

“…There are growing interests in the quest for multi-dimensional applications of herbs; particularly those commonly used among traditional herbal medicine practitioners, for the alleviation of pathologic conditions. 13,17,40 Thus, ethno-botanical bio-prospecting offers another strategy for new herbal remedy discoveries, including those used for alleviation of co-existing liver and kidney pathologic conditions. Additionally, in ethno-medicinal practices, herbs are either administered raw or subjected to hydrothermal processing prior to their application.…”