Aqueous Extract of Terminalia chebula Induces Apoptosis in Lung Cancer Cells Via a Mechanism Involving Mitochondria-mediated Pathways

Wang, Meiling; Yang, Limin; Ji, Musi; Zhao, Pengwei; Péng, Shigē; Bai, Ruixia; Tian, Yunpeng; Su, Liping; Li, Cunbao

doi:10.1590/s1516-8913201400202

Cited by 11 publications

(6 citation statements)

References 24 publications

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“…The reported IC 50 values against A-549 and MCF-7 were 208.16 ± 3.7, and 643.13 ± 4.2 µg/mL, respectively [15]. Furthermore, the aqueous extract of T. chebula was found to induce apoptosis in A-549 cell line via mitochondria-mediated pathway controlled by the Bcl-2 family members, Bcl-2, Bcl-xI and Bax proteins [16]. Similarly, in an in vivo study conducted by Ahuja et al (2013), it was concluded that the ethanolic extract of T. chebula significantly reduced the tumor growth in mice, with EAC induced cancer, apart from increasing their lifespan and restoring the haematological homeostasis [17].…”

Section: Introductionmentioning

confidence: 96%

Phyto-Mediated Synthesis of Silver Nanoparticles Using Terminalia chebula Fruit Extract and Evaluation of Its Cytotoxic and Antimicrobial Potential

Ankegowda¹,

Kollur

Prasad

et al. 2020

Molecules

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The increasing interest in developing potent non-toxic drugs in medicine is widening the opportunities for studying the usage of nanostructures in the treatment of various diseases. The present work reports a method for a facile and an eco-friendly synthesis of silver nanoparticles (AgNPs) using Terminalia chebula fruit extract (TCE). The obtained AgNPs was characterized by using different spectroscopic and microscopic techniques. The analysis of the results revealed that the as-obtained AgNPs have spherical morphology with an average diameter of 22 nm. Furthermore, the preliminary bioactivity evaluations revealed that the bio-conjugation of AgNPs, using TCE, significantly enhanced the antibacterial and anti-breast cancer potentials of the latter. The antibacterial activity of the as-prepared AgNPs showed that B. subtilis was more sensitive towards the AgNPs, followed by P. aeruginosa; while, E. coli and S. mutans showed comparatively minimal sensitivity toward the AgNPs. The IC50 values of TCE, AgNPs and TCE + AgNPs treatment of MCF-7 were found to be 17.53, 14.25 and 6.484 µg/mL, respectively. Therefore, it can be ascertained that the bio-conjugation may provide a headway with regard to the therapeutic employment of T. chebula, upon mechanistically understanding the basis of observed antibacterial and anticancer activities.

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Section: Introductionmentioning

confidence: 96%

Phyto-Mediated Synthesis of Silver Nanoparticles Using Terminalia chebula Fruit Extract and Evaluation of Its Cytotoxic and Antimicrobial Potential

Ankegowda¹,

Kollur

Prasad

et al. 2020

Molecules

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“…GA molecular mechanism showed a decrease in Ki-67 expression and promotion in cell apoptosis associated with the inhabitation of the Hippo pathway (Sun and Wang, 2020). T. chebula as a natural agent is a suitable candidate for further investigation in the treatment and cancer prevention (Wang et al, 2015).…”

Section: Anticancer Propertiesmentioning

confidence: 99%

Current Medical Applications of Terminalia Chebula: An Overview

2022

pnr

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Medicinal plants have long been used, and many of them are known today as drug production sources. The study and research of medicinal plants used in traditional medicine and their various effects in the treatment of some diseases can help produce new drugs. Terminalia chebula, known as the Haritaki plant, has always been at the top of Chinese, Tibetan, Ayurveda, and Iranian traditional medicines. Its classification is based on the size, shape, and growth of the fruit. We have done a thorough literature search in databases and collected the data and research results indexed in PubMed, Elsevier, and Institute for Scientific Information (ISI), Scientific Information Database, Google Scholar databases, and various books up to 2020. It has pharmacological uses such as neuroprotective, hepatoprotective, cardioprotective, antidiabetic, renoprotective, antifungal, antiviral, antibacterial, antimicrobial, antimutagenic, antiproliferative, antioxidant, antiarthritic, and antifertility properties. It also can act as an immunomodulator and anticancer agent. There are some available drugs obtained from T. chebula. Due to the different and wide pharmacological uses of Terminalia chebula, further studies are required to develop new drugs.

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“…The final weight of the extracts was obtained, and the percentage yield of the extracts was determined. The extracts were stored in the dark at 4°C until further use (Wang et al, 2015). The percentage yield obtained was 23.36% (initial yield = 18.791 g and final yield = 4.390 g).…”

Section: Plant Materialsmentioning

confidence: 99%

The toxicogenic effect of Terminalia phanerophlebia Engl. & Diels leaf extract on oxidative stress parameters in an in vitro Hek293 model

Nyahada¹,

Amoako²,

Somboro³

et al. 2021

J Pharm Pharmacogn Res

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Context: Medicinal plants are a highly sought-after alternative to current pharmaceutical drugs because they can be locally cultivated, inexpensive and possess minimal adverse effects. Given that Terminalia phanerophlebia (TP) possesses many useful properties and plays a role in modulating lethal diseases, the cytotoxic effect should be evaluated before its application for therapeutic use. Aims: To investigate the oxidative effect and molecular mechanisms of TP on human embryonic kidney (HEK293) cells. Methods: 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) and adenosine triphosphate (ATP) assays were used to determine the cell viability whilst the thiobarbituric acid reactive species (TBARS) assay was used to detect lipid peroxidation. Endogenous antioxidants, catalase, superoxide dismutase, glutathione peroxidase, heat shock protein 70 and nuclear factor erythroid 2-related factor 2 (Nrf2), were used as oxidative stress markers and were detected via western blotting. Results: A decrease in cell viability with an IC50 of 1.36 mg/mL and ATP were noted. The concentration of malondialdehyde (MDA) increased significantly (p<0.005). Superoxide dismutase, Nrf2 and heat shock protein concentrations were increased. However, glutathione, glutathione peroxidase and catalase were depleted. Conclusions: The results obtained suggest that Terminalia phanerophlebia extract is toxicogenic and induced oxidative stress in HEK293 cells.

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Aqueous Extract of Terminalia chebula Induces Apoptosis in Lung Cancer Cells Via a Mechanism Involving Mitochondria-mediated Pathways

Cited by 11 publications

References 24 publications

Phyto-Mediated Synthesis of Silver Nanoparticles Using Terminalia chebula Fruit Extract and Evaluation of Its Cytotoxic and Antimicrobial Potential

Phyto-Mediated Synthesis of Silver Nanoparticles Using Terminalia chebula Fruit Extract and Evaluation of Its Cytotoxic and Antimicrobial Potential

Current Medical Applications of Terminalia Chebula: An Overview

The toxicogenic effect of Terminalia phanerophlebia Engl. & Diels leaf extract on oxidative stress parameters in an in vitro Hek293 model

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