Effect of oral supplementation of the linoleic and gammalinolenic acids on the diabetic pregnant rats

Abstract

The aim of this work was to evaluate the direct protective action of oral fatty acid supplementation against the deleterious effect of hyperglycemia on maternal reproductive outcomes; fetal growth and development on female Wistar rats. The animals were distributed into four experimental groups: G1= non-diabetic without supplementation (Control group); G2= non-diabetic treated with linoleic (LA) and gammalinolenic acid (GLA) (1 mL of Gamaline-V/day); G3= diabetic without supplementation and G4= diabetic treated with LA and GLA. Diabetes was induced by streptozotocin (40 mg/kg). At day 21 of pregnancy, the gravid uterus was weighed and dissected to count the dead and live fetuses, resorption, implantation, and corpora lutea numbers. The fetuses were analyzed for external and internal anomalies. The treatment with Gamaline-V supplementation to diabetic rats interfered in the maternal reproductive outcome (reduced number of live fetuses and embryonic implantation); however, it protected the deleterious on the incidence of congenital anomalies caused by hyperglycemia

Beneficial effects of Hibiscus rosa-sinensis L. flower aqueous extract in pregnant rats with diabetes

“…The usage of plant-derived antioxidants is considered as an alternative strategy for improving oxidative damage in diabetes. There is evidence that hyperglycemia-mediated oxidative stress induces free radical generation, which leads to maternal complications [ 10 – 12 ] and fetal distress [ 13 – 14 ]. The extract of flowers of H .…”

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“…Использование растений с антиоксидантным эффектом рассматривается как альтернативная терапевтическая стратегия для улучшения окислительного повреждения при диабете [19]. Имеются данные о том, что опосредованный гипергликемией окислительный стресс индуцирует образование свободных радикалов, что приводит к осложнениям у матери [20,21,22] и плода [23].…”