Cefuroxime axetil loaded gastroretentive floating tabletsbased on hydrophilic polymers: preparation and in vitro evaluation

Mohapatra, Snehamayee; KumarKar, Rajat; Mohapatra, Debendra K.; Sahoo, Sabuj; Barik, B. B.

doi:10.1590/s1516-89132012000200013

Cited by 6 publications

(4 citation statements)

References 20 publications

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“…A higher MDT indicates a higher drug release retarding ability of the polymer and vice versa. 47 Values of MDT of all the formulations are mentioned in table 13. By looking towards MDT values it could be said that as the concentration of MSP powder and JSP powder ameliorates, a slight rise in MDT was observed.…”

Section: Mean Dissolution Time (Mdt)mentioning

confidence: 99%

Design and Development of Captopril Gastro-Retentive Tablet Using Natural Polymers of Maize and Jowar Plant

Gayakwad¹,

Bavaskar²,

Fulzele³

et al. 2023

Int J Life Sci Pharm Res

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Nowadays, the use of natural polymers as an alternative to synthetic gastro-retentive polymers is increasing. Such natural raw materials are highly biocompatible and biodegradable with no or significantly fewer side effects and are economical too. The main aim of this research work was to design a gastro-retentive tablet of Captopril by using Maize Stem Pith (MSP) powder and Jowar Stem Pith (JSP) as novel natural low-density polymers and also to sustain the drug release for up to 12 hours. Our objective behind this research is to prepare the gastro-retentive tablet, evaluate it for floating behavior, and to achieve the sustained release effect for at least 12 hours. The novelty of this research work is that MSP powder and JSP powder possesses low density. Thus, gastro-retentive tablets with a low-density (floating) approach can be prepared at a very lost cost compared to the currently marketed formulation. Gastro-retentive tablets of Captopril were designed by using MSP and JSP powder. Using design-expert® version 13, the formulations were prepared using a 32-complete factorial design. The gastro-retentive tablet showed good floating behavior and dissolution pattern, which sustains the release of the drug for up to 12 hours. The optimization study using a contour plot and response surface plot suggested that formulation R9 is an optimized batch among all batches. The current research indicated that there is an increase in floating time with a corresponding decline in the dissolution rate of the tablet as the concentration of MSP powder and JSP powder increases. The optimized formulation R9 consists of MSP powder and JSP powder at 12% and 8 %, respectively, in combination with HPMC (K-100M), and has proven excellent floating behavior and expected drug release pattern. Therefore, MSP powder and JSP powder could be used as suitable low-density novel polymers to design gastro-retentive tablets of Captopril.

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Section: Mean Dissolution Time (Mdt)mentioning

confidence: 99%

Design and Development of Captopril Gastro-Retentive Tablet Using Natural Polymers of Maize and Jowar Plant

Gayakwad¹,

Bavaskar²,

Fulzele³

et al. 2023

Int J Life Sci Pharm Res

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“…The FTIR scan of pure drug (Glimepiride), polymers (HPMC K15M and kappa carrageenan) and physical mixture of drug-polymer were taken. The pure drug, polymer and physical mixture were separately mixed with IR grade KBr [13][14][15] . This mixture was punched to form a disc, which was scanned over a wave number range of 4000 to 400 cm-1.…”

Section: Drug Excipient Compatibility Study 16mentioning

confidence: 99%

“…The final optimization of floating GLM formulation was done by applying Simplex lattice design (SLD) [9][10][11] using kappa carrageenan, HPMC K15M and sodium bicarbonate as independent variables. The simplex lattice design for a threecomponent system is represented by an equilateral triangle in two-dimensional space [12][13][14][15] . The levels of the variables were decided from preliminary studies and the tablets were prepared by wet granulation technique using PVP K30.…”

Section: Introductionmentioning

confidence: 99%

Formulation and Optimization of Gastro retentive Glimepiride Floating Matrix Tablets

Kamere

S.V²,

G.V³

2022

Int J Life Sci Pharm Res

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The main objective of this research investigational studies is to formulate floating matrix tablets of glimipride by applying simplex centroid design for optimization technique and by direct compression method. The simplex Centroid configuration was drilled as an enhancement strategy by adjusting the amount of three components all the while and holding back their total concentration constant. Ingredients HPMC K15m, Kappa-carrageenan and sodium bicarbonate as X1,X2,X3 independent Variables while response variables Y1 floating lag time Y1, Percentage drug released after 1 hour Y2% and t90 time required for 90% were considered as response variable factors for formulation and optimization of total 14 formulations simplex centroid design was applied. The measures of HPMC K15M (X1), kappa-Carrageenan (X2) and sodium bicarbonate (X3) were utilized as the autonomous factors while coasting slack time (Y1), Percentage drug discharged after 1 hour(Y2) and time required for 90% (t90) were taken as the reaction factors. According to the simplex centroid configuration complete 14 formulations were formulated. Matrices were evaluated for physical parameters, in-vitro buoyancy, swelling ability and adhesion retention period. It was inferred that the blend of kappa carrageenan and HPMC K 15 M builds the adaptability in the release pattern of the drug. This examination sets up the utilization of simplex centroid structure in the advancement of coasting network tablets with least experimentation.

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“…However, the integrity of these tablets did not remain after 0.5 h. It clearly showed that the higher drug release was obtained with increased SLS concentration. This was due to the solubilization effect of SLS, together with the improvement of a hydrophilic environment and wettability of the tablets, which consequently enabled the higher drug release [17,36].…”

Section: Effects Of Hpmc Concentrationmentioning

confidence: 99%

Effects of Formulation Parameters on Properties of Gastric Floating Tablets Containing Poorly Soluble Drug: Diclofenac Sodium

2018

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Objective: The objective of this study was to prepare and investigate the effects of formulation parameters on the properties of gastric floating tablets containing diclofenac sodium (DICL) as a model of poorly soluble acidic drug, sodium bicarbonate (NaHCO3) or calcium carbonate (CaCO3) as gas-forming agent, hydroxypropyl methylcellulose (HPMC) K100M or K15M as swelling polymer and sodium lauryl sulfate (SLS) as wetting agent.Methods: DICL floating tablets were prepared using direct compression method. The compressed tablets were evaluated for tablet properties, swelling index, and in vitro buoyancy. The in vitro release under non-sink condition was determined. Molecular interaction was studied using differential scanning calorimetry and fourier transform infrared spectroscopy.Results: The tablet properties of all DICL floating tablets were within the acceptance criteria. The molecular interaction between DICL and excipients in the formulation was excluded. Depends on the formulation compositions, the swelling index at 3 h (SI) ranged from 44±11 to 1158±33 %, whereas the buoyancy properties namely floating lag time (FLT) and total floating time (TFT) were 0.33±0.03 to 10.04±0.04 min and 10.0±0.0 to>12 h, respectively. NaHCO3 showed higher swelling, buoyancy and release properties compared to those of CaCO3. NaHCO3 at 20% gave sufficient swelling (SI of 1074±16 %), buoyancy (FLT of 0.39±0.03 min, TFT of>12 h) and release properties (cumulative release of 5.83±0.02 %). HPMC K100M showed better swelling property of which its initial swelling rate was 1412±25 %/h compared to HPMC K15M (1042±31 %/h). HPMC K100M at 20% showed better buoyancy and release properties compared to those obtained from HPMC K100M at 30%. The release testing under non-sink conditions was able to distinguish the effect of formulation parameters on the DICL release profiles. Incorporation of SLS at 0.25% could enhance both release rate and cumulative release of DICL from the floating tablets. Nevertheless, it showed the unacceptable adverse effect on swelling and buoyancy properties of DICL floating tablets. The TFT of DICL floating tablets containing 0.25% SLS was only 0.5±0.0 h.Conclusion: DICL floating tablets were successfully prepared. Tablets possessing suitable swelling and buoyancy properties were obtained using NaHCO3 at 20% as a gas-forming agent, with HPMC K100M at 10 and 20% as floating matrix and swelling polymer. Addition of SLS as wetting and solubilizing agent showed the unacceptable adverse effect on the swelling and buoyancy properties of DICL floating tablets. The release under sink conditions and/or in vivo pharmacokinetic studies shall be further performed.

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Cefuroxime axetil loaded gastroretentive floating tabletsbased on hydrophilic polymers: preparation and in vitro evaluation

Abstract: ABSTRACT

Cited by 6 publications

References 20 publications

Design and Development of Captopril Gastro-Retentive Tablet Using Natural Polymers of Maize and Jowar Plant

Design and Development of Captopril Gastro-Retentive Tablet Using Natural Polymers of Maize and Jowar Plant

Formulation and Optimization of Gastro retentive Glimepiride Floating Matrix Tablets

Effects of Formulation Parameters on Properties of Gastric Floating Tablets Containing Poorly Soluble Drug: Diclofenac Sodium

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