Antidiabetic activities of ethanol extract of dry matters of culture broth of Coriolus versiolor in submerged culture

Abstract

The study aimed to investigate the antihyperglycemic and antilipidperoxidative effects of ethanol extract of the dry matter from culture broth of Coriolus versicolor (ECBC) in streptozotocin-induced diabetes mice. Blood glucose level, insulin level, total cholesterol (TC), triglyceride (TG), low density lipoprotein-cholesterol(LDL-C), high density lipoprotein -cholesterol (HDL-C) in serum and reduced glutathione level (GSH), lipid peroxidation

Hypoglycemic and Hypolipidemic Effects of Oldenlandia Corymbosa Against Alloxan Induced Diabetes Mellitus in Rats

“…Concomitantly, a decrease in GSH and catalase activity was observed in the diabetic rats. The results presented in this study are in agreement with the other authors where they also reported decreased levels of GSH in diabetic rats [29,30]. A significant elevation of GSH levels and catalase in diabetic induced rats were observed after treatment with O. corymbosa extracts might be due to its protective efficacy.…”

“…Increase in the levels of LPO was observed in the diabetic induced rats. An increase in the levels of LPO in the diabetic induced rats may be due to the increase in oxidative stress in the cells which resulted from depletion of antioxidant scavenger systems [29]. In the current study, a significant decrease in LPO levels was observed in diabetic rats that received 100 mg/kg and 200 mg/kg of O. corymbosa extracts respectively as compared to the diabetic control group.…”

Hypoglycemic effects of glabridin, a polyphenolic flavonoid from licorice, in an animal model of diabetes mellitus

“…The management of diabetes is considered a global problem. Modern drugs, including insulin and other hyperglycemic agents such as biguanides and sulphonylureas control the blood glucose level only when they are regularly administered, although these treatments are laborious and have several disadvantages including hypoglycemia and obesity (3). Therefore the identification of efficacious agents with less severe side-effects is crucial.…”

Cogumelos uma fonte promissora de compostos ativos para o desenvolvimento de produtos farmacêuticos e nutracêuticos

“…Exemplos de atividades farmacológicas experimentalmente confirmadas, exibidas por substâncias encontradas em cogumelos, são: hipolipidêmica, antiarterosclerótica 27,28 , hipocolesterolêmica e diurética (importantes na prevenção e tratamento de doenças cardiovasculares), imunomoduladora (que resulta indiretamente em atividade antitumoral, aumento de resistência a infecções e amenização de reações alérgicas) 29 , antioxidante 30 , hepatoprotetora, antiparasitária, anti-inflamatória, antidiabética 31,32 e moduladora da produção de hormônios 3,33 .…”

“…O diabetes mellitus é a doença endócrina mais comumente encontrada na população, com variadas causas na sua etiologia e patogenesia. Atividades antidiabéticas do extrato etanólico da matéria seca do caldo de Coriolus versiolor, obtido por fermentação submersa, foi estudado 31 . Nesse estudo, os autores observaram melhora nos quadros de hiperglicemia, hiperlipidemia, estresse oxidativo e atividade protetora contra as células pancreáticas β em ratos com diabetes induzida por estreptozotocina.…”