The response of young and adult rats to the riboflavin supplementation

Abstract

ABSTRACT

Riboflavin: The Health Benefits of a Forgotten Natural Vitamin

“…A study has proposed an association of RF intake and blood pressure modulation. In animal studies, RF as supplementation did not provoke the side effects, but did provoke a significant systolic blood pressure reduction which was not age dependent between young and adult rats [94].…”

Riboflavin may ameliorate neurological motor disability but not spatial learning and memory impairments in murine model of multiple sclerosis

“…Treatments started after the first day the clinical signs were observed (days 9e14 post- immunization). Afterwards, the mice were orally gavaged on a daily basis by riboflavin (Puritan's Pride Co., 1233 Montauk Highway Oakdale, NY 11769-9001, United States)/water for two weeks [17] or subcutaneously treated with INF-b1a (RECIGEN ® , CinnaGenCo., Tehran, Iran)/sodium acetate buffer for two weeks [4]. In the group [T3], the mice received a combination of riboflavin and interferon beta -1a ( Fig.…”

“…The total cellular RNA from the whole brain and the spinal cord was extracted using the RNA extraction system of Qiagen ® according to manufacturer's protocol (RNeasy ® Lipid Tissue Mini Kit, Hilden, Germany). cDNA was synthesized from 5 mg of total RNA via the oligo (dt) [12][13][14][15][16][17][18] primers (Invitrogen TM by Life Technologies, Frankfurter, Germany) according to the manufacturer's protocol. cDNA samples were stored at À20 C for further use.…”

Effects of Emerita brasiliensis flour supplementation on normotensive (Wistar) and spontaneously hypertensive rats (SHR)

“…Given this, new alternative therapies to treat the hypertension and related diseases (França et al 2010) have encouraged studies on the possible effects of the biopolymer chitin-chitosan, commonly found in the carapace of crustaceans such as Emerita brasiliensis, in reducing the blood pressure (Kanauchi et al 1994). Another important factor for the use of this animal is the fact that it is easily found throughout the Brazilian coast, being quite consumed by the local population.…”