Riboflavin may ameliorate neurological motor disability but not spatial learning and memory impairments in murine model of multiple sclerosis

Abstract

s u m m a r yBackground & aims: Riboflavin has an important role in myelin formation. This experimental study assesses the interactions between the effects of riboflavin and interferon beta-1a (INF-b1a) on motor disability, spatial learning and memory, and brain-

Avian riboflavin deficiency causes reliably reproducible peripheral nerve demyelination and, with vitamin supplementation, rapid remyelination

“…Riboflavin deficiency has also been implicated as a risk factor for multiple sclerosis and has been proposed as a putative neuroprotective agent for this demyelinating disease. 11,12…”

“…The principal differential diagnosis is Marek’s disease, which is caused by a herpesvirus, and results in neoplastic infiltration and enlargement of peripheral nerves by T-cell lymphoma (neurolymphomatosis). 5,12,13…”

“…Riboflavin deficiency has also been implicated as a risk factor for multiple sclerosis and has been proposed as a putative neuroprotective agent for this demyelinating disease. 11,12 Naturally-occurring riboflavin deficiency Although riboflavin is poorly stored in humans, a pure deficiency (ariboflavinosis) is rare in Western countries due to its presence in amounts exceeding normal requirements in many foods. When this deficiency does occur, for example in malabsorption syndromes, riboflavin deficiency is generally associated with a multi-vitamin deficiency, and the signs and symptoms manifest partly reflect these other deficiencies.…”

“…The principal differential diagnosis is Marek's disease, which is caused by a herpesvirus, and results in neoplastic infiltration and enlargement of peripheral nerves by T-cell lymphoma (neurolymphomatosis). 5,12,13 Treatment and prevention of riboflavin deficiency relies on an adequate supply of this vitamin. Two, 100 µm doses of riboflavin will correct this deficiency in chickens, followed by inclusion of an adequate level in the ration.…”

Riboflavin Inhibits Histamine-Dependent Itch by Modulating Transient Receptor Potential Vanilloid 1 (TRPV1)

“…Riboflavin (known as vitamin B2) is a water-soluble member of the B-vitamin family found in food and used as a dietary supplement with a molecular weight (MW) of 376.4 g/mol (Figure 1A). In previous studies, riboflavin was found to be associated with motor function and anti-allergic effects in several diseases (Morawiecki, 1955;Coimbra and Junqueira, 2003;Bashford et al, 2017;Naghashpour et al, 2019). Because high doses of riboflavin promote the recovery of some motor functions in Parkinson's disease (Coimbra and Junqueira, 2003), we first performed the rotarod test to exclude the influence of motor activity on behavioral assessments in the present study.…”