Effect of microalga Spirulina platensis (Arthrospira platensis) on hippocampus lipoperoxidation and lipid profile in rats with induced hypercholesterolemia

Abstract

Studies have been conducted on microalga

Spirulina as a protein source in the nutritional recovery of Wistar rats

“…However, this was expected, since this fraction represented about two-thirds of the total cholesterol (Miller 1993). The values of HDL (29.80 to 35.65 mg.dL-1) obtained in this study did not differ among themselves and were similar to those found by Bertolin et al (2009) for the rats with hypercholesterolemic diet and the diet with Spirulina (32.3 mg.dL-1). The LDL/HDL ratio is commonly calculated to assess the risk of coronary heart disease.…”

“…The results showed that despite the treatment with 8.8% of Spirulina (S1) had the lowest values of triacylglycerol (TAG), there was no significant difference among the four treatments. The mean TAG among the groups was 78.28 mg.dL-1, which was lower than those obtained by Cerqueira et al (2008) and Bertolin et al (2009) for the male Wistar rats. The study groups showed no significant difference in the iron content.…”

“…The S2 treatment showed higher values (p≤0.05) than the control for total cholesterol, LDL, and LDL/HDL ratio. The levels of total cholesterol for this treatment were higher than those reported as normal (56 to 76 mg.dL-1) by Souza-Soares et al (2009) and those obtained by Bertolin et al (2009). The latter authors, after dealing with male Wistar rats for 60 days with hypercholesterolemic diet and Spirulina, found 99.1 and 65.1 mg.dL-1 for total cholesterol in the rats with 30 days of hypercholesterolemic diet and 30 days of a diet with Spirulina, respectively.…”

Antioxidant effect of phycocyanin on oxidative stress induced with monosodium glutamate in rats

“…The use of natural antioxidants and dietary supplements have been the object of many studies, with several reports that the phenolic compounds not only increase the food shelf-life, but also act as antioxidants in many biological systems (Milié et al, 1998;Estrada et al, 2001;Colla, 2008;Bertolin, 2009). Spirulina (Arthrospira) has been studied extensively not only due to its potential as protein source, but also due to its therapeutic potential in several areas, including the ability to prevent and inhibit the cancer, reduce the blood cholesterol, stimulate the immunological system, reduce the renal toxicity of pharmaceutical products and toxic metals, promote protection against the damage generated by radiation and the damage caused by oxidative stress (Belay, 2002;Bertolin, 2009)…”

Thermal and photo-stability of the antioxidant potential of Spirulina platensis powder

“…Several studies have reported the use of microalgae in the treatment and prevention of various diseases, such as hyperlipidemia Bertolin et al, 2009), obesity (Becker et al, 1986), compromised immune system (Pérez et al, 2002), diabetes (Moura et al, 2012), protein deficiency (Donato et al, 2010), hypertension (Torres-Duran et al, 2007) and others (Ambrosi et al, 2008). The nutraceutical properties of these microalgae have been attributed to their chemical composition, which is rich in proteins (60-70%) (Henrikson, 1995), polyunsaturated fatty acids (Colla et al, 2004), phenolic compounds and phycocyanin (Silva, 2008).…”