Hydroxypropylcellulose controlled release tablet matrix prepared by wet granulation: effect of powder properties and polymer composition

Teixeira, Antônio Zenon Antunes

doi:10.1590/s1516-89132009000100021

Cited by 13 publications

(11 citation statements)

References 9 publications

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“…Greater amounts of a hydrophilic matrix rate-controlling polymer (HPC) resulted in slower drug release. The selected HPC was LF grade with a molecular weight of 95 KDa [28,29]. Lower-molecular-weight HPC up to 370 KDa undergoes significant erosion, while diffusion through the swelling gel layer becomes more significant in polymers with a molecular weight above this threshold [30].…”

Section: Discussionmentioning

confidence: 99%

Understanding Direct Powder Extrusion for Fabrication of 3D Printed Personalised Medicines: A Case Study for Nifedipine Minitablets

et al. 2021

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Fuse deposition modelling (FDM) has emerged as a novel technology for manufacturing 3D printed medicines. However, it is a two-step process requiring the fabrication of filaments using a hot melt extruder with suitable properties prior to printing taking place, which can be a rate-limiting step in its application into clinical practice. Direct powder extrusion can overcome the difficulties encountered with fabrication of pharmaceutical-quality filaments for FDM, allowing the manufacturing, in a single step, of 3D printed solid dosage forms. In this study, we demonstrate the manufacturing of small-weight (<100 mg) solid dosage forms with high drug loading (25%) that can be easily undertaken by healthcare professionals to treat hypertension. 3D printed nifedipine minitablets containing 20 mg were manufactured by direct powder extrusion combining 15% polyethylene glycol 4000 Da, 40% hydroxypropyl cellulose, 19% hydroxy propyl methyl cellulose acetate succinate, and 1% magnesium stearate. The fabricated 3D printed minitablets of small overall weight did not disintegrate during dissolution and allowed for controlled drug release over 24 h, based on erosion. This release profile of the printed minitablets is more suitable for hypertensive patients than immediate-release tablets that can lead to a marked burst effect, triggering hypotension. The small size of the minitablet allows it to fit inside of a 0-size capsule and be combined with other minitablets, of other API, for the treatment of complex diseases requiring polypharmacy within a single dosage form.

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Section: Discussionmentioning

confidence: 99%

Understanding Direct Powder Extrusion for Fabrication of 3D Printed Personalised Medicines: A Case Study for Nifedipine Minitablets

et al. 2021

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“…Each sieve along with the retained particles was weighed individually after shaking. The test was completed when the weight on the test sieves did not changed by more than 5% of the previous weight (Teixeira, 2009).…”

Section: Particle Size Distributionmentioning

confidence: 99%

“…(Table II) This in turn depicted the milling process efficiency and cost effectiveness, as the unmilled granules obtained after milling are less. The results are the mean of three replicates (Teixeira, 2009) (Table III).…”

Section: Optimization Of Milling Processmentioning

confidence: 99%

Effects of granule particle size and lubricant concentration on tablet hardness containing large concentration of polymers

Rajani

Kumar

Dwivedi

et al. 2018

Braz. J. Pharm. Sci.

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The objective of this research work is to demonstrate the impact of granule size and lubricant concentration on the hardness of tablets in formulations containing higher concentration of polymers and to resolve the hardness issue during compression process. The work involves optimization of a milling process for size reduction of granules and blending process to achieve tablets of good hardness on compression. To optimize the granule size, different sized co-mill screens were used. The different concentration of lubricant were studied on different sized granules to check the effect on hardness of tablets and to obtained the desired hardness of tablets. Compression of lubricated blend in various concentration was performed using the gravity feeder and force feeder separately to check the impact on the over lubrication effect. This ultimately leads to less hardness tablets. Lubricated blends were evaluated by performing the Bulk Density, Tapped Density, Hausner ratio and compressibility index tests. Tablets were evaluated for the physical characteristics like weight variation, hardness, thickness and dissolution. It has been conclude that on using the optimum granules size and lubricant concentration in formulation, all the downstream problems can be resolved and this in turn helps in compression of tablets and also provides the good hardness to the tablets.

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“…Drug release from HPC matrices is sensitive to HPC molecular weight, particle size, and drug/polymer proportions; coexcipients may also impact release profiles. In a study aiming to attain 100% drug release of water-soluble caffeine after 24 h from HPC tablet matrices, it was shown that increasing HPC/caffeine ratios significantly decreased caffeine release rate …”

Section: Common Types Of Cellulose Ethers; Syntheses Properties and A...mentioning

confidence: 99%

Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters

Arca¹,

et al. 2018

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Cellulose ethers have proven to be highly useful natural-based polymers, finding application in areas including food, personal care products, oil field chemicals, construction, paper, adhesives, and textiles. They have particular value in pharmaceutical applications due to characteristics including high glass transition temperatures, high chemical and photochemical stability, solubility, limited crystallinity, hydrogen bonding capability, and low toxicity. With regard to toxicity, cellulose ethers have essentially no ability to permeate through gastrointestinal enterocytes and many are already in formulations approved by the U.S. Food and Drug Administration. We review pharmaceutical applications of these valuable polymers from a structure-property-function perspective, discussing each important commercial cellulose ether class; carboxymethyl cellulose, methyl cellulose, hydroxypropylcellulose, hydroxypropyl methyl cellulose, and ethyl cellulose, and cellulose ether esters including hydroxypropyl methyl cellulose acetate succinate and carboxymethyl cellulose acetate butyrate. We also summarize their syntheses, basic material properties, and key pharmaceutical applications.

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Hydroxypropylcellulose controlled release tablet matrix prepared by wet granulation: effect of powder properties and polymer composition

Abstract: ABSTRACT

Cited by 13 publications

References 9 publications

Understanding Direct Powder Extrusion for Fabrication of 3D Printed Personalised Medicines: A Case Study for Nifedipine Minitablets

Understanding Direct Powder Extrusion for Fabrication of 3D Printed Personalised Medicines: A Case Study for Nifedipine Minitablets

Effects of granule particle size and lubricant concentration on tablet hardness containing large concentration of polymers

Pharmaceutical Applications of Cellulose Ethers and Cellulose Ether Esters

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