An extract of a formula used in the traditional chinese medicine (Buzhong Yi Qi Wan) alters the labeling of blood constituents with technetium-99m

Giani, Tania Santos; Paoli, Severo de; Presta, G.; Maiworm, Adalgisa Ieda; Santos-Filho, Sebastião David; Brandão-Neto, José; Medeiros, Aldo da Cunha; Fonseca, Adenilson de Souza da; Bernardo-Filho, Mário

doi:10.1590/s1516-89132007000600013

Cited by 3 publications

(6 citation statements)

References 8 publications

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“…Moreover, the findings reported in our work would justify the use of the LWDHW in the TCM. Similar findings were reported by other authors [15] that have observed an alteration on the fixation of the 99m Tc in blood constituents with a magistral formula (Buzhong Yi Qi Wan) that is used to tonify the blood. Putting together these explanations, it is attractive to suppose that it is possible to integrate the concepts of both Western and Eastern Medicines.…”

Section: Discussionsupporting

confidence: 90%

“…This statement has a special relevance to the TCM due to the limited scientific information available about several of the products/procedures used in this medical system. Natural products can alter the labeling of blood constituents with 99m Tc as some authors have previously reported [15,16,[19][20][21]23,40]. The labeling of blood constituents could be decreased due to the action of drugs by (i) binding at the same sites on the blood constituents, (ii) direct inhibition (chelating action) of the stannous and pertechnetate ions, (iii) direct oxidation or generation of free radicals that could oxidize the stannous ion, (iv) antioxidant action impeding or decreasing the stannous ion oxidation, and (v) alteration of the plasma membrane structure or modification of the transport system of stannous and pertechnetate ions into cells [29,33,42].…”

Section: Discussionmentioning

confidence: 97%

“…A relevant consideration is that the number of experimental models for the study of the various properties related with the herbal medicines used in the TCM is still limited and the development of new and suitable models is thus highly desired. Investigations using radionuclides have been worthwhile to aid the understanding of several biological mechanisms and some of them have been used to study procedures used in the TCM, such as acupuncture [15,37,38].…”

Section: Discussionmentioning

confidence: 99%

“…Assays using radionuclides have been utilized successfully in various investigations related with extracts of medicinal formulas [15] or isolated medicinal plant [16].…”

mentioning

confidence: 99%

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An aqueous extract of Liu Wei Di Huang Wan alters the labeling of blood constituents with Technetium-99m

et al. 2013

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The Liu Wei Di Huang Wan is a formula of a traditional Chinese medicine that is used to treat asthma patients and has been shown to have several important properties, such as antioxidant and free radical scavenging activities. The influence of an extract of Liu Wei Di Huang Wan on the labeling of blood constituents with technetium-99m was investigated. Anticoagulated blood (Wistar rats) was incubated with the extract, stannous chloride and technetium-99m, as sodium pertechnetate. Samples were centrifuged and aliquots of plasma and blood cells were separated and precipitated with trichloroacetic acid, to obtain soluble and insoluble fractions of the blood constituents. The percentage of radioactivity (%ATI) in all the fractions was determined. The analysis of the results shows that the extract at the highest concentration used (70 mg/mL) decreased significantly (P<0.05) the %ATI (from 96.48 ± 1.19 to 54.46 ± 7.38) on blood cells compartment, (from 81.11 ± 4.15 to 61.33 ± 4.74) on insoluble fractions of blood cells and (from 65.91 ± 2.44 to 13.15 ± 3.62) on insoluble fractions of plasma. In conclusion, the results suggest that the substances present on this extract can alter this labeling process, probably due to (i) redox properties (antioxidant and chelator activities) and/or (ii) specific actions in the binding sites where the 99mTc would be bound on the blood constituents. As a consequence, precaution is suggested on the interpretation of the nuclear medicine results from performed with blood constituents labeled with 99m Tc in patients that have undertaken LWDHW, although the current findings were obtained in experimental animal models.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

“…Assays using radionuclides have been utilized successfully in various investigations related with extracts of medicinal formulas [15] or isolated medicinal plant [16].…”

mentioning

confidence: 99%

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An aqueous extract of Liu Wei Di Huang Wan alters the labeling of blood constituents with Technetium-99m

et al. 2013

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“…The classic prescriptions and recipes like the aqueous Buzhong Yi Qi Wan extract has oxidant properties that modify the labeling of erythrocytes and with 99m Technetium and could alter the cellular membrane and/or generation of free radicals (Giani et al, 2007).…”

Section: Molecular Imaging Studies On Various Tcm Prescriptions and Rmentioning

confidence: 99%

Current applications of molecular imaging and luminescence-based techniques in traditional Chinese medicine

Wan

Zhang

et al. 2011

Journal of Ethnopharmacology

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Effects of medicinal plants on radiolabeling and biodistribution of diagnostic radiopharmaceuticals: A systematic review

2019

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Radiopharmaceuticals are drugs that contain radioisotopes used for diagnostic and therapeutic purposes. There are evidences that medicinal herbs and their constituents can modify the radiolabeling, biodistribution, and pharmacokinetics of radiopharmaceuticals through drug interaction. To have an overview of the effects and the underlying mechanisms of medicinal plants on the radiolabeling and bioavailability of radiopharmaceuticals, we conducted this study to summarize the current findings in this field. The scientific literature was systematically collected from databases and analyzed. Studies showed that medicinal plants and their constituents can alter radiolabeling and biodistribution via several mechanisms. Interactions with proteins in red blood cells at the same sites, chelating action of stannous and pertechnetate ions, antioxidant action impeding or decreasing stannous ion oxidation, direct oxidation of stannous ions, generation of reactive oxygen species (ROS) which oxidize stannous ions and damage induced in the cell membrane. Most the medicinal plants can decrease the radioactivity of radiopharmaceuticals, but some of them like Peumus boldus, Punica granatum, Nectandra membranacea, Mentha crispa, Rosmarinus officinalis and derivatives such as eugenol and epigallocatechin gallate have increasing effects. In addition, altering feature in some of them is tissue dependent.

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An extract of a formula used in the traditional chinese medicine (Buzhong Yi Qi Wan) alters the labeling of blood constituents with technetium-99m

Cited by 3 publications

References 8 publications

An aqueous extract of Liu Wei Di Huang Wan alters the labeling of blood constituents with Technetium-99m

An aqueous extract of Liu Wei Di Huang Wan alters the labeling of blood constituents with Technetium-99m

Current applications of molecular imaging and luminescence-based techniques in traditional Chinese medicine

Effects of medicinal plants on radiolabeling and biodistribution of diagnostic radiopharmaceuticals: A systematic review

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