Ordered mesoporous silica carrier system applied in nanobiothecnology

Abstract

Ordered mesoporous materials like SBA15 possess a network of channels and pores of well-defined size in the nanoscale range (2-50 nm). This particular pore architecture makes them suitable candidates for hosting and delivery under appropriate conditions of a variety of molecules of pharmaceutical interest, including radiopharmaceuticals. The characteristics of SBA-15 prepared in different temperatures and the behavior of this system regarding microencapsulation of a model drug were investigated. The calcined samples were formed in 0.2 g disks and were soaked in a solution of atenolol used as a model drug. The modification of the aging temperature provoked changes in the structure of the pores, indicating the presence of microporosity and connections between mesopores. Aging the materials at a higher temperature resulted in no microporosity and this fact influenced the control of the release of the model drug.<br>Recentes estudos conduziram à descoberta da sílica mesoporosa com estrutura hexagonal, que apresenta elevada área superficial (700 a 1000 m²/g), tamanho de poros grande (5 a 9 nm) e espessura fina de parede do poro (3,5 a 5,3 nm), chamado SBA-15. Essas características fazem destes materiais matrizes adequadas para a incorporação e liberação controlada, sob condições apropriadas, de uma série de biomoléculas, principalmente radiofármacos. As características do SBA-15 preparado em diferentes temperaturas de envelhecimento e o comportamento desse sistema com relação ao micreoencapsulamento de uma droga modelo foi investigado. As amostras calcinadas foram conformadas em discos e imersas em uma solução saturada de atenolol, usado como droga modelo. A variação na temperatura de tratamento provoca algumas mudanças na estrutura dos poros, indicando a presença de microporosidade e interconectividade entre os mesoporos em condições específicas. Foi observado que materiais envelhecidos a elevadas temperaturas não apresentam microporosidades, e esse fato pode influenciar no controle da liberação da droga

Chemical Regulation of Carbon Quantum Dots from Synthesis to Photocatalytic Activity

“…The NiSBA‐15 modifier was synthesized by the hydrothermal method proposed by Zhao et al. (1998) 57 and an adaptation of Sousa (2005) 58, taking into account the monitoring done in the synthesis of nanostructured material SBA‐15, used to adjust the properties, making them suitable for use of the material. The modifier was prepared with the Si/Ni ratio of 50.…”

Optimization of tetracycline hydrochloride adsorption on amino modified SBA-15 using response surface methodology

“…Thus, the gradual drug release from silica particles was carried out under the same pH. The application of local drug delivery system using implantation or injection has advantages over conventional drug therapies due to lower harmful side effects [64].…”

The role of SBA-15 in drug delivery

“…This system presents a low rate of delivery, followed by a rather constant rate over subsequent hours with a linear regression factor of 0.999. 58 SBA-15-collagen hybrid material was also synthesized by Cao; 59 it was used as a delivery system for ATE. 60 The release kinetics of both ATE/SBA-15 and ATE/SBA-15-collagen presented a lower delivery rate during the rst 10 h. Aer 10 h, the SBA-15 system appeared to be more effective than SBA-15collagen.…”