Glucose metabolism in rats submitted to skeletal muscle denervation

Nunes, Wilton Marlindo Santana; Mello, María Alice Rostom de

doi:10.1590/s1516-89132005000500006

Cited by 9 publications

(9 citation statements)

References 22 publications

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“…The radioactive lactate released into the incubation media was determined by separating the metabolites in an ionic exchange column (Dowex-2, Sigma). To estimate the oxidized glucose (CO 2 production), the radioactivity of the 14 C present in the liquid (hiamina) collected from the inner vial of the incubation system was determined (Nunes & Mello, 2005).…”

Section: Indicators Of Muscular Glycidic Metabolism: Oxidation and Glmentioning

confidence: 99%

Influence of creatine supplementation on indicators of glucose metabolism in skeletal muscle of exercised rats

Araújo

Vieira

Moura

et al. 2013

Motriz: rev. educ. fis.

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Abstract-The purpose of this study was to evaluate the effect of creatine supplementation in the diet on indicators of glucose metabolism in skeletal muscle of exercised rats. Forty Wistar adult rats were distributed into four groups for eight weeks: 1) Control: sedentary rats that received balanced diet; 2) Creatine control: sedentary rats that received supplementation of 2% creatine in the balanced diet; 3) Trained: rats that ran on a treadmill at the Maximal Lactate Steady State and received balanced diet; and 4) Supplemented-trained: rats that ran on a treadmill at the Maximal Lactate Steady State and received creatine supplementation (2%) in the balanced diet. The hydric intake increased and the body weight gain decreased in the supplemented-trained group. In the soleus muscle, the glucose oxidation increased in both supplemented groups. The production of lactate and glycemia during glucose tolerance test decreased in the supplemented-trained group. Creatine supplementation in conjunction with exercise training improved muscular glycidic metabolism of rats.Keywords: somatic index, glucose tolerance, physical activity Resumo-"Influência da suplementação com creatina em indicadores de metabolismo da glucose no músculo esquelético de ratos exercitados." O objetivo deste estudo foi avaliar o efeito da suplementação de creatina na dieta sobre indicadores do metabolismo glicídico musculoesquelético de ratos exercitados. Quarenta ratos Wistar adultos foram divididos em quatro grupos por oito semanas: Controle: receberam dieta balanceada, mantidos sedentários; Controle Creatina: receberam suplementação de creatina (2%) na dieta balanceada, mantidos sedentários; Treinado: correram em esteira na intensidade da máxima fase estável de lactato e receberam a dieta balanceada e grupo Treinado Suplementado: correram em esteira na intensidade da máxima fase estável de lactato e receberam suplementação de creatina (2%) na dieta balanceada. A ingestão hídrica aumentou e o ganho de massa corporal reduziu no grupo treinado e suplementado. No músculo sóleo, a oxidação de glicose aumentou em ambos os grupos suplementados. A produção de lactato e a glicemia durante teste de tolerância à glicose diminuíram no grupo treinado e suplementado. A suplementação com creatina em conjunto com treinamento físico melhorou metabolismo de glicídico muscular dos ratos.Palavras-chaves: índice somático, tolerância à glicose, atividade físicaResumen-"Influencia de la suplementación con creatina sobre indicadores del metabolismo de la glucosa en el músculo esquelético de ratas ejercitadas." El objetivo de este estudio fue evaluar el efecto de la suplementación con creatina en la dieta sobre indicadores del metabolismo de glucosa en el músculo esquelético en ratones ejercitados. Cuarenta ratas macho adultas Wistar se dividieron en cuatro grupos de ocho semanas: Control: recibieron dieta equilibrada, mantenido sedentaria; Control Complementado: La suplementación con creatina recibido (2%) en la dieta equilibrada, sedentaria mantenido; Trained: corrien...

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Section: Indicators Of Muscular Glycidic Metabolism: Oxidation and Glmentioning

confidence: 99%

Influence of creatine supplementation on indicators of glucose metabolism in skeletal muscle of exercised rats

Araújo

Vieira

Moura

et al. 2013

Motriz: rev. educ. fis.

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“…In addition, the glucose blood control is relevant to body functions and it is maintained by glucose intake and glycogen equilibrium between synthesis and consumption (Klip, 1990;Nunes & Mello, 2009). Moreover, this related glucose process could influence the hepatic and muscle glycogen values (Salway, 2004).…”

Section: Introductionmentioning

confidence: 99%

Hepatic glycogen levels in female rats submitted to aquatic therapy after muscle disuse

Fortes¹,

Carvalho²,

Alves

et al. 2017

motricidade

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The aim of the present study was to analyse the changes in liver glycogen content in rats subjected to aquatic therapy post-disuse of the paw. 32 wistar adult female rats were equally divided: Control (C), kept in the cage for two weeks without interventions; Disuse (D) had the right paw immobilized with hip extension, knee and plantar flexion for two weeks; Aquatic Therapy (AT) underwent aquatic therapy with increments of 3 minutes daily for two weeks, totalizing 36 minutes of training; Disused Aquatic Therapy (DTA) was first subjected to immobilization for two weeks and 24 hours after withdrawal of immobilization aquatic therapy was started for two more weeks, in same protocols of D and AT groups. At the end of the experiment, the animals were sacrificed, and tissues were dissected, weighed and stored. The liver tissues were referred analysis of glycogen content. It was observed that the blood glucose levels of the AT group (104 mg/dL) were different from the C group (86 mg/dL; p = 0.0213). Regarding hepatic glycogen, the D (2.35mg±0.07) and AT (2.73mg±0.07) groups had hepatic glycogen reduction by 22% and 15%, relative to C (2.51mg±0.03); p <0.0001). The DTA group presented no differences when compared to the control, suggesting the normalization of the finding. Muscle disuse by two weeks promoted changes in glycogen levels, however, two weeks after disuse condition, the aquatic therapy were able to correct the energetic reserve in liver.

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“…Animal studies suggest that muscular atrophy secondary to denervation can alter systemic energy needs (Nunes and de Mello, 2005). In rats, denervation of skeletal muscle is associated with a reduction in glucose uptake, glycogen synthesis and insulin sensitivity (Nunes and de Mello, 2005).…”

Section: Muscle Atrophy and Denervationmentioning

confidence: 99%

“…In rats, denervation of skeletal muscle is associated with a reduction in glucose uptake, glycogen synthesis and insulin sensitivity (Nunes and de Mello, 2005). Denervation atrophy in the SOD1 mouse leads to diminished entry of pyruvate into the Krebs cycle, thus hampering glucose oxidation in skeletal muscle (Palamiuc et al, 2015).…”

Section: Muscle Atrophy and Denervationmentioning

confidence: 99%

“…Indeed, altered glucose metabolism associated with denervation, is not confined to the affected muscles. Abnormal glucose metabolism has been observed in tissues distant from the site of denervation in animal studies (Nunes and de Mello, 2005). Studies of denervated rats show a generalized reduction in glucose uptake, glycogen synthesis, insulin sensitivity (Nunes and de Mello, 2005) and an enhanced effect of epinephrine on glycogen metabolism (Moruzzi and Bergamini, 1983).…”

Section: Possible Sites For the Origin Of Hypermetabolism In Alsmentioning

confidence: 99%

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Energy metabolism in amyotrophic lateral sclerosis: assessment of body composition and energy expenditure

Ioannides¹

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Glucose metabolism in rats submitted to skeletal muscle denervation

Abstract: ABSTRACT

Cited by 9 publications

References 22 publications

Influence of creatine supplementation on indicators of glucose metabolism in skeletal muscle of exercised rats

Influence of creatine supplementation on indicators of glucose metabolism in skeletal muscle of exercised rats

Hepatic glycogen levels in female rats submitted to aquatic therapy after muscle disuse

Energy metabolism in amyotrophic lateral sclerosis: assessment of body composition and energy expenditure

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