Evaluation of gastric anti-ulcer activity in a hydro-ethanolic extract from Kielmeyera coriacea

Abstract

The antiulcer activity of a hydro-ethanolic extract prepared from the stems of Kielmeyera coriacea Mart. (Guttiferae) was evaluated in rats employing the ethanol-acid, acute stress and Indomethacin models to induce experimental gastric ulcers. Treatment with K coriacea hydro-ethanolic extract provided significant antiulcer protection in the ethanol-acid and Indomethacin models, but not in the acute stress model. These results suggested that the K coriacea hydro-ethanolic extract increased resistance to necrotizing agents, providing a direct, protective effect on the gastric mucosa.<br>A atividade antiulcerogênica do extrato hidroetanólico de caule de Kielmeyera coriacea Mart. (Guttiferae) foi avaliada em ratos por meio de três modelos experimentais: etanol-ácido, indometacina e estresse agudo. O índice ulcerativo observado após o tratamento com o extrato de Kielmeyera coriacea foi comparado com a droga de referência, cimetidina. O tratamento com o extrato mostrou significante atividade anti-ulcerogênica nos modelos de indução de lesões de mucosa gástrica produzidas por etanol-ácido e indometacina, mas não contra úlcera induzida pelo modelo de estresse agudo. Etanol-ácido e agentes antiinflamatórios, como a indometacina, são compostos que produzem úlcera de mucosa gástrica. Os resultados deste estudo sugerem uma atividade protetora de mucosa gástrica para o extrato de Kielmeyera coriace

Anti-inflammatory activities of ethanolic extract of Carica papaya leaves

“…However the result indicates that only the extract dose of 800 mg/Kg can produce gastric effect that is similar to a standard ulcerogenic dose of indomethacin. The design of the ulcerogenic test and the result obtained closely resemble that of other authors (Goel et al, 1986;Singh et al, 1994;Olajide et al, 1998;Pandit et al, 2000;Goulart et al, 2005). Although a higher dose of indomethacin was used in this study compared with those of the anti-inflammatory studies, nevertheless the dose of indomethacin used for the ulcerogenic test was in accordance with standard practices since a lower dose of indomethacin may not have produced gastric irritation during the short days of administration as is the case in this study.…”

Gastric antiulcer, antisecretory and cytoprotective properties of celery (Apium graveolens) in rats

“…This inhibition leads to a deficiency in endogenous prostaglandin E 2 and PGI 2 which in turn cause microcirculatory disturbances in the gastric mucosa (Shorrock & Rees, 1989). The mechanisms involved in prostaglandin action are multiple, including stimulation of mucus and bicarbonate output, enhancement of gastric mucosal blood flow, decreasing gastric motility, and stimulation of cellular growth and repair (Goulart et al, 2005). Our observations that the celery extract prevented gastric lesions induced by indomethacin, may be explained by the ability of celery extract to generate endogenous prostaglandins in stomach tissue.…”

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“…To regain the balance, different therapeutic agents are used to inhibit the gastric acid secretion or to boost the mucosal defence mechanisms by increasing mucosal protection, stabilizing the surface epithelial cells or interfering with the prostaglandin synthesis. The causes of gastric ulcer pyloric ligation are believed to be due to stress induced increase in gastric hydrochloric acid secretion and or stasis of acid and the volume of secretion is also an important factor in the formation of ulcer due to exposure of the unprotected lumen of the stomach to the accumulating acid 14 .…”