Editorial

Bernardo-Filho, Mário; Marques, Ruy Garcia; Moura, Egberto Gaspar de

doi:10.1590/s1516-89132002000500001

Cited by 1 publication

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Diagram of the diagram steps involved in the labellin of RBCs with 99mTc. The labeling of RBCs depends on optimal stannous chloride concentrations [6,36,48]. Since the stannous ion is easily oxidized, it is postulated that the observed increases in RBC labeling in the plasma (plasma proteins).…”

Section: Discussionmentioning

confidence: 99%

“…There are some studies about the effect of the In this study, we have presented a review with the results of the effect of two kinds of tobacco (normal and light), Peumus boldus (P. boldus) and Thuya occidentalis (T. occidentalis) extracts on the labelling of RBC and plasma and cellular proteins with 99mTc using an in vitro [6,7] technique. carried out without sacrificing the animals.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Effect of Drugs on the Labeling of Blood Elements with Technetium-99m

Braga

Oliveira²,

Feliciano³

et al. 2000

CPD

Self Cite

View full text Add to dashboard Cite

The influence of drugs on the labeling of red blood cells and plasma proteins with 99mTc has been reported. Any drug, which alters the labeling of the tracer, could be expected to modify the disposition of the radiopharmaceuticals. Red blood cells (RBC) labeled with technetium-99m (99mTc) are used for several evaluations in nuclear medicine. We have evaluated the effect of Thuya occidentalis, Peumus boldus and Nicotiana tabacum (tobacco) extracts on the labeling of RBC and plasma and cellular proteins with 99mTc. Blood was incubated with the drugs. Stannous chloride (SnCl2) solutions and 99mTc were added. Plasma (P) and blood cells (BC) were separated. The percentage of radioactivity (%ATI) bound to P and BC was determined. The %ATI on the plasma and cellular proteins was also evaluated by precipitation of P and BC samples with trichloroacetic acid (TCA) and isolation of soluble (SF) and insoluble (IF) fractions. The analysis of the results shows that there is a decrease in %ATI (from 97.64 to 75.89 percent) in BC with Thuya occidentalis extract. The labeling of RBC and plasma proteins can be decreased in presence of tobacco. This can be due either a direct or indirect effect (reactive oxygen species) of tobacco. The analysis of radioactivity in samples of P and BC isolated from samples of whole blood treated with Peumus boldus showed a rapid uptake of the radioactivity by blood cells in the presence of the Peumus boldus, whereas there was a slight decrease in the amount of 99mTc radioactivity in the TCA-insoluble fraction of plasma. This study shows that extracts of some medicinal plants can affect the radiolabeling of red blood cells with 99mTc using an in vitro technique.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%