Cytogenetic and teratological effects of mancozeb pre natal exposure on rats

Castro, V. L. S. S. de; Tambasco, A. J.; Paraíba, L. C.; Tambasco, D. D.

doi:10.1590/s1516-89131999000200001

Cited by 9 publications

(4 citation statements)

References 26 publications

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“…In addition, Castro et al confirmed the absence of menstrual cycle alteration in Wister rats exposed to mancozeb concentrations. At the same time, mancozeb do not influence the number of live pup births [37].…”

Section: In Vivo Experimental Studiesmentioning

confidence: 90%

“…To this aim, Cuomo et al suggested that ethylene thiourea exposure in mouse models leads to a remarkable dysregulation of ovarian aging biomarkers, affecting ovarian health [46]. Environmental exposure to ETU, in fact, induces alterations in the estrous cycle, considered the beginning of an early reproductive senescence [37,39,40,46,50]. In addition, Atmaca et al found that mancozeb induces a progressive decline in steroid synthesis in bovine luteal cells [35].…”

Section: Discussionmentioning

confidence: 99%

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Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models

Bianchi

Nottola

Torge

et al. 2020

IJERPH

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Mancozeb is a widely used fungicide approved for use in agriculture in many countries with long persistence in the environment and consequent bioaccumulation in tissues and biological fluids. Despite the large amount of studies published in recent years, the relationship between mancozeb exposure and female reproductive health is not fully elucidated. In order to summarize current evidence on mancozeb exposure and female reproductive disease, we performed a systematic review of literature. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were used to make this review. An adapted version of the National Toxicology Program's Office of Health and Assessment and Translation (OHAT) framework was used to evaluate the risk of bias. Electronic search on two databases (PubMed and Scopus) was used to find experimental studies (in vitro and in vivo) on mancozeb exposure. The database search identified 250 scientific articles, 20 of which met our inclusion criteria. Selected data were then reviewed and summarized in tables. Overall, mancozeb represents a hazard for female reproductive health, with different mechanisms of action. Undoubtedly more experimental and epidemiological studies are required to definitively validate mancozeb as reproductive toxicant.

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Section: In Vivo Experimental Studiesmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models

Bianchi

Nottola

Torge

et al. 2020

IJERPH

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“…In general, the number of evidences confirming the negative link between the mancozeb and the reproductive system is increasing [1]. Further, the teratogenic impact of mancozeb was reported by considering the ability of mancozeb to cross the rat placental barrier following the administration of 2-3 g/kg mancozeb in Castro's work and 50-500 mg/kg in Rossi's work [17, 34]. Furthermore, a significant decrease in Johnsen's score and spermatogenic cells of first-generation pups in mancozeb-treated group could lead to infertility or a considerable decrease in fertility.…”

Section: Discussionmentioning

confidence: 99%

Preventative Effects of Vitamin E on Testicular Damage and Sperm Parameters in the First-Generation Mice Pups due to Pre- and Postnatal Mancozeb Exposure

Saddein

Haghpanah

Nematollahi-Mahani

et al. 2019

Journal of Toxicology

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The present study aimed to evaluate the effects of vitamin E on mancozeb-induced testis damage of the first-generation pups during intrauterine and lactating periods. Two groups of pregnant NMRI mice received 500 mg/kg mancozeb (MNZ) as MNZ group and 200 mg/kg vitamin E as MNZ+vit.E group before receiving MNZ. In addition, a vehicle and a control group were designed every other day in gestation and lactation periods. The male pups from each group were maintained until adulthood (8-10 W). The left testes and epididymides were removed following the sacrifice of the pups. Then, they were weighed, and sperm parameters including number, viability, motility, and morphology and testis structure were evaluated. A significant decrease occurred in sperm parameters of the mancozeb-treated pups compared to the control and vehicle groups. Treatment with vitamin E reversed the deleterious effects of MNZ to a nearly normal condition. Testis parameters including the weight, gonadosomatic index, seminiferous tubule diameters, and Johnsen’s score, as well as the number of germ cells such as spermatogonia, spermatocyte, spermatid, and Sertoli, decreased significantly in the MNZ group, compared to the amount in the control and vehicle groups. Interestingly, the treatment with vitamin E was reversed in most of these parameters. Based on the results, the exposure of pups to mancozeb during pregnancy and lactating periods negatively affects the reproductive system of male pups. However, the coadministration of vitamin E could prevent the deleterious effects of mancozeb on sperm and testis parameters.

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“…Initially, the use of these chemicals appeared to be lawlessly and effective until excessive and indiscriminate usage became rampant consequently creating problems for human health and the natural atmosphere. Some researchers recorded teratogenicity, residual toxicity, carcinogenicity, prolonged degradation period, ecological pollution, exorbitant cost, and development of resistance among target pests to be associated with some of the commonly used chemicals [10,11]. 10 reported health risks related to ethyl chlorpyrifos, methylchlorpyrifos, and omethoate residues in tomato fruits.…”

Section: E Physicalmentioning

confidence: 99%

Use of liquid smoke for sustainable food preservation and postharvest loss and waste reduction (A review)

2019

J. appl. phys. sci.

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The primary aim of every post-harvest technology is to prolong shelf life and maintain produce quality. Recent efforts to extend the shelf life of agricultural produces have culminated in the use of various methods, among which some have dangerous side effects to human health and the environment, others are just too expensive due to the high cost of production thereby making their usage unsustainable and uneconomical. Among the safe and sustainable alternatives under development, Liquid Smoke (LS) appears to have very remarkable potentials. However, the Postharvest Loss and Waste (PHLW) reduction potential of LS have been highly underrepresented in both scienti ic and non-scienti ic literature. This work, therefore, analyses and bring to light the potentials of LS for reducing postharvest losses and prolonging the shelf life of agricultural produce. The usage against insect infestation, microorganism attack, and physiological disorder of products are discussed. A careful compilation of recent literature reporting various waste materials for producing LS is also reported in this work. The active components (carbonyls, organic acids, and Phenols) responsible for its potency in reducing food loss are also discussed. Finally, a simple conceptual framework is used to illustrate the strategic and systematic role played by LS in reducing PHLW, conserving the environment, and contributing to Sustainable Development Goals (SDGs).

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Cytogenetic and teratological effects of mancozeb pre natal exposure on rats

Abstract: ABSTRACT

Cited by 9 publications

References 26 publications

Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models

Association between Female Reproductive Health and Mancozeb: Systematic Review of Experimental Models

Preventative Effects of Vitamin E on Testicular Damage and Sperm Parameters in the First-Generation Mice Pups due to Pre- and Postnatal Mancozeb Exposure

Use of liquid smoke for sustainable food preservation and postharvest loss and waste reduction (A review)

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