Smudge cells in peripheral blood smears did not differentiate chronic lymphocytic leukemia from other B-cell chronic lymphoprolipherative diseases

Abstract

Smudge cells, also known as Gumprecht cells 1 are ragged lymphoid cells found mainly in peripheral blood smears of patients with chronic lymphocytic leukemia (CLL) and other B-cell chronic lymphoproliferative diseases (CLD). Smudge cells are not simply artifacts of slide preparations and there is Smudge cells in peripheral blood smears did not differentiate chronic lymphocytic leukemia from other B-cell chronic lymphoprolipherative diseases Sombras nucleares no esfregaço do sangue periférico não diferenciam a leucemia linfocítica crônica das outras doenças linfoproliferativas B crônicas

High percentage of smudge cells in a patient with COVID19: Rediscovering their utility

“…A chest X-ray evidenced a typical pattern of COVID-19, and a positive PCR confirmed SARS-CoV-2 infection. Laboratory workup showed mild leukocytosis (14 000/mm 3 ) with absolute lymphocytosis (56%; 7880/mm 3 ), thrombocytosis (507 000/mm 3 for CD20 (dim) , CD23 (high) , CD200 (high) , and CD43 (dim) with moderate specificity [1], and correlates with better prognosis and prolonged time to first treatment [2][3][4]. Interestingly, the characteristic ease with which these cells are broken, more than a laboratory artefact is related with the amount of vimentin cellular content [4].…”

Automated quantification of apoptosis in B‐cell chronic lymphoproliferative disorders: a prognostic variable obtained with the Cell‐Dyn Sapphire (Abbott) automated hematology analyzer

“…Subsequently, Matos et al . (2009) in the evaluation of chronic lymphoproliferative disorders of B lymphocyte reported (using the cutoff of 10%, 20% and 30%), the proportion of smudge cells was reduced in a statistically significant manner in the morphologically atypical B‐CLL and leukemic NHL compared to typical B‐CLL, but have not found a relationship with the prognosis (TTT and survival).…”

“…Matutes and Polliack (2000) [4] have reported that the percentage of smudge cells in morphologically atypical CLL and in leukemic lymphomas is considerably less than for typical B-CLL, although higher than in normal samples. Subsequently, Matos et al (2009) [16] in the evaluation of chronic lymphoproliferative disorders of B lymphocyte reported (using the cutoff of 10%, 20% and 30%), the proportion of smudge cells was reduced in a statistically significant manner in the morphologically atypical B-CLL and leukemic NHL compared to typical B-CLL, but have not found a relationship with the prognosis (TTT and survival).…”

Lymphocytosis with Smudge Cells Is Not Equivalent to Chronic Lymphocytic Leukemia

“…SCs are most commonly associated with CLL and are often interpreted as evidence of a CLL diagnosis. Matos et al [6] demonstrated that SCs had an odds ratio of only 1.97 for discriminating CLL from other LPDs. A more recent review showed frequent presence of SCs in out-of-hospital cardiac arrests, infections, hematological, and solid cancers.…”