T-Cell Project: an international, longitudinal, observational study of patients with aggressive peripheral T-cell lymphoma

Fédérico, Massimo; Bellei, Monica; Pesce, Emanuela; Zucca, Emanuele; Pileri, Stefano; Montoto, Silvia; Weisenburger, Dennis D.; Rüediger, Thomas; Ko, Young Hyeh; Liang, Raymond; Zinzani, Pier Luigi; Connors, Joseph M.; Foss, Francine M.; Horwitz, Steven M.; Polliack, Aaron; Vose, Julie M.

doi:10.1590/s1516-84842009000800007

Cited by 8 publications

(9 citation statements)

References 26 publications

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“…Five-year overall survival and progressionfree survivals were 44 % (95 % CI 40-47) and 33 % (95 % CI 30-37), respectively. The ALCL, ALK+ showed the best 5-year survival rates (73, 95 %CI 61-82) [32]. These data were extremely well received and considered to be essential in the efforts to better understand the natural history of these challenging and heterogeneous diseases, as well as the emerging patterns of care these patients receive around the world.…”

Section: The T-cell Projectmentioning

confidence: 94%

“…This study is designed as a prospective collection of information that are potentially prognostic for newly diagnosed patients with the more frequent subtypes of PTCL-NOS and AITL and to better define clinical characteristics and outcome of the more uncommon subtypes (extranodal NK/T cell lymphoma; enteropathy-type T cell lymphoma; hepatosplenic gamma-delta T cell lymphoma; subcutaneous panniculitis-like T cell lymphoma; anaplastic large-cell lymphoma, T/null cell, primary systemic type) [30,31]. Thus far, this registry has provided several platforms to overcome previous challenges in collecting data.…”

Section: The T-cell Projectmentioning

confidence: 99%

“…Results of diverse preliminary analyses have been reported for both COMPLETE [18,[33][34][35][36][37] and the T-Cell Project [30][31][32][38][39][40][41][42]. The production originated so far from the two registries is summarized in Table 2.…”

Section: Future Goals and Directionsmentioning

confidence: 99%

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The Value and Relevance of the T Cell Lymphoma Registries and International Collaborations: the Case of COMPLETE and the T-Cell Project

Bellei

Nabhan

Pesce

et al. 2015

Curr Hematol Malig Rep

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Peripheral T cell lymphomas (PTCLs) are a heterogeneous group of lymphoid malignancies that portend a poor prognosis and have an undefined optimal therapeutic strategy. Data on best practices stem from prior studies that have generally included B cell lymphomas. However, the enhanced ability to diagnose PTCLs, the development of newer agents specific for PTCLs, and its increased incidence have called the scientific community to develop better strategies to combat these neoplasms. To that end, T cell lymphoma registries were developed in an attempt to answer relevant questions on the prognosis and management of PTCLs. The largest registries currently enrolling patients are the Comprehesive Oncology Measures for PeripheraL T-cEll Lymphoma TrEatment (COMPLETE) and the T-Cell Project. Despite the inherent limitations of these studies, valuable information are being collected to refine our management approaches and to aid in designing future clinical trials. This review illustrates the value of these registries and describes the critical questions that need to be answered.

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Section: The T-cell Projectmentioning

confidence: 94%

Section: The T-cell Projectmentioning

confidence: 99%

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The Value and Relevance of the T Cell Lymphoma Registries and International Collaborations: the Case of COMPLETE and the T-Cell Project

Bellei

Nabhan

Pesce

et al. 2015

Curr Hematol Malig Rep

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“…The study was conducted in compliance with the Helsinki Declaration of 1975 as revised in 1983, was approved by the appropriate research ethics committees and required each patient to provide written informed consent before registration. This study is designed as a prospective collection of information that are potentially prognostic for newly diagnosed patients with the more frequent subtypes of PTCL, not otherwise specified (PTCL‐NOS) and Angioimmunoblastic T‐Cell Lymphoma (AITL) and to better define clinical characteristics and outcome of the more uncommon subtypes (Extranodal NK/T‐cell lymphoma; Enteropathy‐type T‐cell lymphoma; Hepatosplenic T‐cell lymphoma; Peripheral gamma‐delta T‐cell lymphoma; Subcutaneous panniculitis‐like T‐cell lymphoma; Anaplastic large‐cell lymphoma, T/null cell, primary systemic type) . Data collection was done via electronic Case Report Forms (eCRFs) at a dedicated website (http://www.tcellproject.org), with the adoption of SSL03 technology assuring protection in web communications of subject's clinical data.…”

Section: Methodsmentioning

confidence: 99%

Pitfalls and major issues in the histologic diagnosis of peripheral T‐cell lymphomas: results of the central review of 573 cases from the T‐Cell Project, an international, cooperative study

Bellei

Sabattini

Pesce

et al. 2016

Hematological Oncology

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Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of neoplasms that are derived from post-thymic lymphoid cells at different stages of differentiation with different morphological patterns, phenotypes and clinical presentations. PTCLs are highly diverse, reflecting the diverse cells from which they can originate and are currently sub-classified using World Health Organization (WHO) 2008 criteria. In 2006 the International T-Cell Lymphoma Project launched the T-Cell Project, building on the retrospective study previously carried on by the network, with the aim to prospectively collect accurate data to improve knowledge on this group of lymphomas. Based on previously published reports from International Study Groups it emerged that rendering a correct classification of PTCLs is quite difficult because the relatively low prevalence of these diseases results in a lack of confidence by most pathologists. This is the reason why the T-Cell Project requested the availability of diagnostic material from the initial biopsy of each patient registered in the study in order to have the initial diagnosis centrally reviewed by expert hematopathologists. In the present report the results of the review process performed on 573 cases are presented. Overall, an incorrect diagnosis was centrally recorded in 13.1% cases, including 8.5% cases centrally reclassified with a subtype eligible for the project and 4.6% cases misclassified and found to be disorders other than T-cell lymphomas; 2.1% cases were centrally classified as T-Cell disorders not included in the study population. Thus, the T-Cell Project confirmed the difficulties in providing an accurate classification when a diagnosis of PTCLs is suspected, singled out the major pitfalls that can bias a correct histologic categorization and confirmed that a centralized expert review with the application of adequate diagnostic algorithms is mandatory when dealing with these tumours. Copyright © 2016 John Wiley & Sons, Ltd.

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“…O linfoma linfoblástico do tipo T é abordado em vários manuscritos e, dentre eles, o projeto internacional de células T, 3 com a participação de pesquisadores de instituições do mundo inteiro, sinaliza os aspectos do estudo observacional sobre linfomas periféricos agressivos de células T.…”

Section: This Year In Brazil Together With the Curitiba Congress Of unclassified

8º Encontro Anual da Associação Ítalo-Brasileira de Hematologia

Ruiz¹

2009

Rev. Bras. Hematol. Hemoter.

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Neste ano, no Brasil, no Congresso Brasileiro da Sociedade Brasileira de Transplante de Medula Óssea (SBTMO) de Curitiba, a Associação Italo-Brasileira de Hematologia (AIBE) realiza o seu oitavo encontro anual. E, como já é habitual, a AIBE brinda mais uma vez a comunidade hematológica e os participantes do Congresso da SBTMO com mais um suplemento educativo, de atualização, o terceiro na história, sobre temas relevantes na área de onco-hematologia e, em especial, em doenças linfoproliferativas. À guisa de informação e de recordação, a Associação Ítalo-Brasileira de Hematologia (AIBE) surgiu de uma ideia, que de sonho se transformou em realidade, de congregarem italianos e brasileiros em torno da hematologia. Em Genova, Itália, precedido de encontros anteriores, a Associação foi formalizada e, após trâmites burocráticos entre os especialistas de ambos os países, foi definido que os encontros anuais seriam alternados entre estes países, assim como os cargos diretivos. Dentre os aspectos educacionais e cooperativos acordados foi definido que a AIBE teria como órgão oficial de divulgação científica a Revista Brasileira de Hematologia e Hemoterapia (RBHH). Com esta medida, a AIBE passou a ter um peso relevante no sucesso da RBHH, através da inclusão de vários dos seus membros no conselho editorial da revista, produção de manuscritos e de suplementos educativos e atualizados, como o atual, contribuindo ativamente para o progresso e aprimoramento do veículo científico da comunidade hematológica brasileira.Neste suplemento, o segundo do ano da RBHH, mais uma vez a maioria dos temas que serão abordados durante o evento está presente, e as experiências de brasileiros e italianos poderão ser atestadas em suas páginas.Os manuscritos publicados foram elaborados com a característica de minirrevisões atuais, e que abordam temas relevantes da onco-hematologia. Os linfomas de Hodgkin são revistos e, em um dos artigos deste suplemento, Bacigalupo 1 discute os resultados do transplante alogênico mieloablativo, apresentando resultados de estudos em que a alta taxa de mortalidade torna intolerável a indicação do procedimento, sugerindo que este, se ocorrer, a opção deverá ser com regime de condicionamento de intensidade reduzida.Os linfomas não Hodgkin são abordados em vários artigos. Em um deles, de Souza CA e colaboradores 2 apresentam a experiência brasileira do tratamento sequencial de altas doses de quimioterapia seguida do transplante autólogo. O estudo retrospectivo apresenta uma grande série de This year in Brazil, together with the Curitiba Congress of the Brazilian Society of Bone Marrow Transplants (SBTMO), the Italo-Brazilian Association of Hematology (AIBE) will hold its eighth annual meeting. As is now customary, AIBE once again offered to the Brazilian hematological community and the participants of the SBTMO Congress an education supplement update, the third in history, with relevant topics in the field of oncohematology and especially about lymphoproliferativepacientes com doença de Hodgkin e linfoma não Hodgkin co...

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T-Cell Project: an international, longitudinal, observational study of patients with aggressive peripheral T-cell lymphoma

Cited by 8 publications

References 26 publications

The Value and Relevance of the T Cell Lymphoma Registries and International Collaborations: the Case of COMPLETE and the T-Cell Project

The Value and Relevance of the T Cell Lymphoma Registries and International Collaborations: the Case of COMPLETE and the T-Cell Project

Pitfalls and major issues in the histologic diagnosis of peripheral T‐cell lymphomas: results of the central review of 573 cases from the T‐Cell Project, an international, cooperative study

8º Encontro Anual da Associação Ítalo-Brasileira de Hematologia

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