Hemofilia no estado de Santa Catarina: estudo clínico

Hoepers, Andréa Thives de Carvalho

doi:10.1590/s1516-84842008000200020

Cited by 3 publications

(3 citation statements)

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“…Among the coagulopathy group, the prevalence of HBsAg and total anti-HBc was 3.9% and 31.4%, respectively. These results were higher than those found in the South region of Brazil (HBsAg prevalence of 2.9% and prevalence of total anti-HBc of 28.5%) [ 33 , 34 ]. These differences may have been due to the classification of haemophilia and VWD that lead to frequent blood transfusion and a higher risk of exposure to HBV [ 12 , 22 , 23 ].…”

Section: Discussioncontrasting

confidence: 68%

“…In coagulopathy patients, anti-HCV prevalence was 47% which is higher than that found in the Southeast region (39.4%) [ 34 ], Northeast region (42.2%) [ 41 ] and South region of the country (34.16%) [ 34 ] and could have been the result of different types of coagulopathy included in each study. The anti-HCV prevalence was 34.9%, 29.7% and 12% in individuals affected by haemophilia A, haemophilia B and VWD, respectively [ 23 ].…”

Section: Discussionmentioning

confidence: 91%

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Cross-Sectional Study to Determine the Prevalence of Hepatitis B and C Virus Infection in High Risk Groups in the Northeast Region of Brazil

Barbosa

Bezerra

Carvalho-Costa

et al. 2017

IJERPH

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Background: HBV (Hepatitis B Virus) and HCV (Hepatitis C Virus) infections are more prevalent in vulnerable populations than the general population. The objective of this study was to investigate the prevalence of HBV and HCV infection in HIV-positive patients (GI), chronic renal failure (CRF) patients (GII) and coagulation disorder individuals (GIII). Methods: A cross-sectional study was conducted from June 2014 to March 2015. Serum samples were tested for markers of hepatitis B and C by enzyme-linked immunosorbent assay (ELISA). Sociodemographic, epidemiological, clinical and laboratory data and accompanying statistical analyses were performed using Epi Info™ 7. Results: A total of 348 individuals were recruited, i.e., 154 HIV-positive, 143 CRF and 51 coagulopathy patients. Among them, more than 66% were men, and the predominant age group was 26–35 years in GI and 56–65 years in GIII. Most patients had more than 8 years of education (66.2% in GI, 60.6% in GIII and 46.1% in GII), with a family income between 100–400 dollars in more than 48% of patients. The prevalence of the HBsAg marker was 3.9%, 7% and 3.9%, total anti-HBc was 28.6%, 55.9% and 31.4%, and anti-HCV was 1.3%, 12.6% and 47% for GI, GII and GIII, respectively. However, the prevalence of anti-HBs was greater than 70% in all groups. Conclusions: This study shows a high prevalence of HBV and HCV among specific groups compared to the general population. Factors such as age, income, number of sexual partners, sexually transmitted disease burden, blood transfusion history or blood products and blood transfusions before 1994 were associated with a higher prevalence for these infections.

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Section: Discussioncontrasting

confidence: 68%

Section: Discussionmentioning

confidence: 91%

Cross-Sectional Study to Determine the Prevalence of Hepatitis B and C Virus Infection in High Risk Groups in the Northeast Region of Brazil

Barbosa

Bezerra

Carvalho-Costa

et al. 2017

IJERPH

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“…Resultado que condiz com a literatura 11 . Hoepers 24 reitera com seu estudo conduzido com hemofílicos residentes no Estado de Santa Catarina, no qual, foi observado que à artropatia hemofílica, acomete principalmente as articulações dos joelhos. A artropatia hemofílica gera um quadro de contraturas fixas em flexão dessas articulações, favorecendo uma resposta compensatória de flexão de quadril e uma posição em plante flexão do tornozelo, podendo levar a uma postura escoliótica 11 .…”

Section: Discussionunclassified

Frequência de alterações posturais em hemofílicos

et al. 2018

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INTRODUÇÃO: A hemofilia é uma doença crônica de origem genética causada por uma mutação dos genes que codificam os fatores de coagulação sanguíneos. Uma das consequências dessa alteração é o acometimento do sistema musculoesquelético, o que pode influenciar na postura desses indivíduos. OBJETIVO: Estimar a frequência de alterações posturais em portadores de hemofilia, e identificar possíveis fatores associados. MÉTODOS: Estudo descritivo de corte transversal, conduzido com indivíduos com idade ≥ 18 anos, com diagnóstico de hemofilia, em acompanhamento na Fundação de Hematologia e Hemoterapia da Bahia (HEMOBA). Os participantes foram submetidos à avaliação postural, por meio da análise visual, teste de Adams e aplicação de um formulário semi-estruturado. Empregou-se o Epi Info® (v.3.5.2) para análise dos dados e, para verificar a existência de associações entre as variáveis do estudo foram utilizados os Testes exato de Fisher, Qui-quadrado (bicaudal) e Qui-Quadrado com a correção de Yates. Consideradas como estatisticamente significantes associações com p <0,05. RESULTADOS: Participaram deste estudo 29 hemofílicos, com média de idade de 34,9 ± 12,6 anos, 25 (86,2%) informaram ter artropatia hemofílica. Dos participantes da pesquisa 13 (68,4%) apresentaram postura escoliótica detectada pelo teste de Adams. A alteração foi mais frequente nos indivíduos com mais de uma articulação afetada pela artropatia hemofílica, com valor estatisticamente significativo para esta variável (p= 0,039). CONCLUSÃO: As frequências de alterações posturais em indivíduos com hemofilia são elevadas com associação significativa para os indivíduos com idade superior a 40 anos e com mais de uma articulação afetada pela artropatia hemofílica.

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