A doença falciforme no Brasil

Cançado, Rodolfo Delfini; Jesus, Joice Aragão de

doi:10.1590/s1516-84842007000300002

Cited by 149 publications

(106 citation statements)

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“…1 It has been estimated that more than seven million people have hemoglobin S in Brazil, and that more than 25,000 to 30,000 people have the homozygote form, with more than 3,500 new cases born every year. 1,2 In the S-beta globin gene, a normal codon (GAG) is replaced by another (GTG), thus resulting in exchanging the sixth amino acid of the beta globin. This exchange of glutamic acid for valine causes polymerization of hemoglobin S, when exposed to media with low oxygen tension, which leads to sickling of red blood cells.…”

Section: Introductionmentioning

confidence: 99%

Results from transcranial Doppler examination on children and adolescents with sickle cell disease and correlation between the time-averaged maximum mean velocity and hematological characteristics: a cross-sectional analytical study

Hokazono

Silva

et al. 2011

Sao Paulo Med. J.

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CONTEXT AND OBJECTIVE: Transcranial Doppler (TCD) detects stroke risk among children with sickle cell anemia (SCA). Our aim was to evaluate TCD findings in patients with different sickle cell disease (SCD) genotypes and correlate the time-averaged maximum mean (TAMM) velocity with hematological characteristics. DESIGN AND SETTING: Cross-sectional analytical study in the Pediatric Hematology sector, Universidade Federal de São Paulo. METHODS: 85 SCD patients of both sexes, aged 2-18 years, were evaluated, divided into: group I (62 patients with SCA/Sß0 thalassemia); and group II (23 patients with SC hemoglobinopathy/Sß+ thalassemia). TCD was performed and reviewed by a single investigator using Doppler ultrasonography with a 2 MHz transducer, in accordance with the Stroke Prevention Trial in Sickle Cell Anemia (STOP) protocol. The hematological parameters evaluated were: hematocrit, hemoglobin, reticulocytes, leukocytes, platelets and fetal hemoglobin. Univariate analysis was performed and Pearson's coefficient was calculated for hematological parameters and TAMM velocities (P < 0.05). RESULTS: TAMM velocities were 137 ± 28 and 103 ± 19 cm/s in groups I and II, respectively, and correlated negatively with hematocrit and hemoglobin in group I. There was one abnormal result (1.6%) and five conditional results (8.1%) in group I. All results were normal in group II. Middle cerebral arteries were the only vessels affected. CONCLUSION: There was a low prevalence of abnormal Doppler results in patients with sickle-cell disease. Time-average maximum mean velocity was significantly different between the genotypes and correlated with hematological characteristics.

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Section: Introductionmentioning

confidence: 99%

Results from transcranial Doppler examination on children and adolescents with sickle cell disease and correlation between the time-averaged maximum mean velocity and hematological characteristics: a cross-sectional analytical study

Hokazono

Silva

et al. 2011

Sao Paulo Med. J.

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“…(1) The distribution of the HbS gene in Brazil is quite heterogeneous and depends on the racial composition of the population in a given region. The prevalence of heterozygotes is higher in the northern and northeastern regions of the country (6-10%) and lower in the southeastern and southern regions (2-3%).…”

Section: To the Editormentioning

confidence: 99%

“…Data from the Brazilian National Ministry of Health presented in a study conducted by Cançado & Jesus in 2007 (1) showed that there were 25,000-30,000 patients with sickle cell anemia in Brazil. In addition, approximately 3,500 new cases of the disease are diagnosed in Brazil each year.…”

Section: To the Editormentioning

confidence: 99%

Anemia falciforme: uma importante causa potencial de hipertensão pulmonar no Brasil

Padua

Martinez

2012

J. bras. pneumol.

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“…A Ética no Aconselhamento Genético: um Desafio à Educação Médica cimo de bem-estar, tendo sido uma das razões para a inclusão da anemia falciforme no pacote de doenças genéticas testadas no Programa de Triagem Neonatal brasileiro 19,20 . No caso de doenças incuráveis e sem tratamento, o aconselhamento genético é objeto de delicadas negociações entre profissionais da saúde e movimentos sociais.…”

Section: Cristiano Guedes and Debora Dinizunclassified