Reticulocyte parameters in hemoglobinopathies and iron deficiency anemia

Cortellazzi, Laura C.; Teixeira, Sérgio Henrique; Borba, Ronaldo; Gervásio, Sirlei; Cintra, Carmem S.; Grotto, Helena Zerlotti Wolf

doi:10.1590/s1516-84842003000200005

Cited by 18 publications

(28 citation statements)

References 10 publications

(15 reference statements)

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“…The assessment of reticulocyte maturation might be useful for understanding the different pathophysiology of these anemias and can help in differential diagnosis (30). Iron status influences reticulocyte subsets; the erythroid expansion leads to an enhanced immature reticulocyte release from bone marrow to compensate the anemic status.…”

Section: Discussionmentioning

confidence: 99%

Erythrocyte and reticulocyte parameters in iron deficiency and thalassemia

Urrechaga

Borque

Escanero

2011

J. Clin. Lab. Anal.

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Section: Discussionmentioning

confidence: 99%

Erythrocyte and reticulocyte parameters in iron deficiency and thalassemia

Urrechaga

Borque

Escanero

2011

J. Clin. Lab. Anal.

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“…Subsequently, new algorithms, including conventional as well as innovative hematological parameters, were assessed for subgroups with microcytic erythropoiesis. Nowadays automated reticulocyte counts provide new parameters to evaluate marrow activity [29]. It is therefore important to establish accurate and reliable criteria for both identifying the speciic causes of anemia and evaluating the impact of intervention strategies.…”

Section: Resultsmentioning

confidence: 99%

“…Reticulocyte count was used in the clinical and laboratory practice for a long time due to three main factors: technical limitations in the detection of cell, the imprecision of manual microscopic method, and high coeicient of variations in counts [28,29]. The index is the corrected value in relation to total red blood cell mass and Hb%.…”

Section: Screen For Uncorrected Reticulocyte Countmentioning

confidence: 99%

Laboratory Approach to Anemia

Yenilmez¹,

Tuli²

2018

Current Topics in Anemia

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Anemia is a major cause of morbidity and mortality worldwide and can be deined as a decreased quantity of circulating red blood cells (RBCs). The epidemiological studies suggested that one-third of the world's population is afected with anemia. Anemia is not a disease, but it is instead the sign of an underlying basic pathological process. However, the sign may function as a compass in the search for the cause. Therefore, the prediagnosis revealed by thorough investigation of this sign should be supported by laboratory parameters according to the underlying pathological process. We expect that this review will provide guidance to clinicians with indings and laboratory tests that can be followed from the initial stage in the anemia search.

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“…Modern automated cell counters produce more accurate results than the manual method and provide information about reticulocyte immaturity, due to the use of fluorescent stains that bind to ribosomal RNA 17. There is great variability across the different analytical platforms in the additional parameters generated by automated analysers; thus, it is difficult to validate them as diagnostic tools.…”

Section: Discussionmentioning

confidence: 99%