Erythrocyte and reticulocyte parameters in iron deficiency and thalassemia

Urrechaga, Eloísa; Borque, L.; Escanero, Jesús F.

doi:10.1002/jcla.20462

Cited by 39 publications

(41 citation statements)

References 34 publications

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“…Iron deficiency is one of the most common nutritional deficiencies, worldwide, and this deficiency is responsible for frequent disability and death. The main causes of iron balance are excessive menstrual bleeding in women of childbearing age and chronic blood loss in the gastrointestinal tracts of elderly subjects (Urrechaga et al, 2011). Iron deficiency progresses from replete iron stores to a depletion of iron stored in the body.…”

Section: Introductionmentioning

confidence: 99%

Detection of human erythrocytes influenced by iron deficiency anemia and thalassemia using atomic force microscopy

Zhang

Wang

et al. 2012

Micron

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Section: Introductionmentioning

confidence: 99%

Detection of human erythrocytes influenced by iron deficiency anemia and thalassemia using atomic force microscopy

Zhang

Wang

et al. 2012

Micron

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“…The count depends on total RBC count [12]. For both the pathophysiological classiication of anemia and to monitor marrow response after therapeutic interventions, reticulocyte count is clinically important [11,19].…”

Section: Screen For Uncorrected Reticulocyte Countmentioning

confidence: 99%

Laboratory Approach to Anemia

Yenilmez¹,

Tuli²

2018

Current Topics in Anemia

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Anemia is a major cause of morbidity and mortality worldwide and can be deined as a decreased quantity of circulating red blood cells (RBCs). The epidemiological studies suggested that one-third of the world's population is afected with anemia. Anemia is not a disease, but it is instead the sign of an underlying basic pathological process. However, the sign may function as a compass in the search for the cause. Therefore, the prediagnosis revealed by thorough investigation of this sign should be supported by laboratory parameters according to the underlying pathological process. We expect that this review will provide guidance to clinicians with indings and laboratory tests that can be followed from the initial stage in the anemia search.

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“…Glede na velikost in obarvanost eritrocitov, ki ju določa-jo klasični eritrocitni parametri (PVE, PHE, PKHE), v klinični praksi ločimo hipokromno mikrocitno SDA in normokromno normocitno AKLB. Taka delitev je tudi zaradi velikega vpliva predanalitičnih dejavnikov le delno uporabna, zato se danes v diagnostiki anemij priporoča uporaba novih eritrocitnih in retikulocitnih parametrov (9)(10)(11)(12). Ker pa gre za novejše parametre, katerih imena in načini določanja so lahko patentno zaščiteni, je njihovo določanje odvisno od vrste analizatorja (7,13).…”

Section: Uvodunclassified

Primerjava eritrocitnih in retikulocitnih parametrov pri ugotavljanju pomanjkanja železa

Jarc

Zupan²,

Ponikvar³

et al. 2017

SlovMedJour

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Background: Te increased prevalence of iron defciency anemia represents a global public health issue which can be reduced by early diagnosis of pre-iron defcient states. Clinical utility of biochemical indices for iron defciency diagnosis is limited due to the inﬂuence of inﬂammation. Erythrocyte and reticulocyte indices, reticulocyte hemoglobin content, and percentage of hypochromic red cells have been extensively used in diagnosing diﬀerent iron-defcient conditions. Te aim of our study was to compare the utility of erythrocyte and reticulocyte indices provided by diﬀerent hematology analyzers for the diagnosis of iron defciency.Methods: 186 people, 25 patients with iron defciency anemia, 103 patients with chronic kidney disease, and 58 healthy donors were included in our study. Teir whole blood samples were analyzed using two diﬀerent automated analyzers, XN-1000, Sysmex and Advia 120, Siemens Bayer Diagnostics, to compare reticulocyte and erythrocyte indices.Results: Linear correlation between indices for hemoglobin reticulocyte content (Ret-He and CHr) has been confrmed while correlation between both erythrocyte indices (Hypo-He and %HYPO) can be described by 2nd degree polynomial. Cut-oﬀ value for the diagnosis of iron defciency for Ret-He was established at < 28.2 pg and for Hypo-He at > 1.6 % and showed high diagnostic sensitivity (RetHe = 76 %; Hypo-He = 72 %) and specifcity (100 %).Conclusions: Reticulocyte indices Ret-He and CHr are directly comparable and can be used for latent iron defciency evaluation. Although erythrocyte indices Hypo-He and %HYPO are not exchangeable, both can be used for long-term iron defciency evaluation. Additionally, we determined reference intervals for Hypo-He and Ret-He.

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Erythrocyte and reticulocyte parameters in iron deficiency and thalassemia

Abstract: Erythrocytosis and severe microcytosis, together with a high percentage of microcytes and a moderate increase in IRF, is the profile of β-thalassemia carriers, whereas anisocytosis and the hypochromic subset correlates with the severity of the anemia in iron-deficient patients.

Cited by 39 publications

References 34 publications

Detection of human erythrocytes influenced by iron deficiency anemia and thalassemia using atomic force microscopy

Detection of human erythrocytes influenced by iron deficiency anemia and thalassemia using atomic force microscopy

Laboratory Approach to Anemia

Primerjava eritrocitnih in retikulocitnih parametrov pri ugotavljanju pomanjkanja železa

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