Low frequency of bipolar disorder, dopamine dysregulation syndrome, and punding in Brazilian patients with Parkinson's disease

Kümmer, Arthur; Dias, Fernando Machado Vilhena; Cardoso, Francisco; Teixeira, Antônio Lúcio

doi:10.1590/s1516-44462010000100012

Cited by 10 publications

(12 citation statements)

References 14 publications

(21 reference statements)

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“…Rapid cycling is defined being more than four phases per year, whereas ultrarapid cycling (URC) and ultrarapid ultradian cycling (URUC) are defined by switches within a few days and within a few hours, respectively. Kummer et al [7] described a sample of six Parkinson patients with bipolar disorder. In all cases manic or hypomanic episodes had already appeared before the onset of Parkinson's disease and, furthermore, the authors supposed that Parkinson's disease accelerates the frequency of episodes.…”

Section: Is Parkinson's Disease a Risk For Rapid Cycling?mentioning

confidence: 99%

Bipolar Affective Disorder and Parkinson's Disease

Engmann¹

2011

Case Reports in Medicine

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Little is known about comorbidities of bipolar disorder such as Parkinson's disease. A case history and a literature survey indicate that bipolar disorder is linked with or influences Parkinson's disease and vice versa. Underlying mechanisms are poorly understood, and, more importantly, no treatment options are established in such double diagnoses. The few data in comorbid Parkinson cases seem to point to a rapid cycling pattern of bipolar symptoms. With regard to therapeutic intervention, the literature supports pramipexole for treatment of both Parkinson and depressive symptoms in bipolar depression. Lithium, the mood stabilizer of choice for treating manic states, is problematical for use in Parkinson patients because of its side effects. Valproate might be an alternative, especially for treatment of rapid cycling.

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Section: Is Parkinson's Disease a Risk For Rapid Cycling?mentioning

confidence: 99%

Bipolar Affective Disorder and Parkinson's Disease

Engmann¹

2011

Case Reports in Medicine

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“…Hypomania and mania in the structure of bipolar disorder (BD), foreshadowing the manifestion of PD, is rare, however, there are data on isolated clinical cases in the literature [10,62]. According to foreign literature, the prevalence of BD varies from 1% in the case of BD I and 5% in BD II, it is noteworthy that both manic and hypomanic episodes were recorded by patients or their caregivers only until the manifestation of motor symptoms and did not recur after the onset of dopaminergic of therapy, in 3% of patients with BD hypomania changed to depresion [63]. BD increases risk of disorders, impulse control, drug abuse, development of drug hypomania [64].…”

Section: Affective Disordersmentioning

confidence: 99%

Affective and personality disorders in Parkinson's disease premotor phase. Pilot study.

Samushiya¹,

Ragimova²,

Смоленцева³

et al. 2020

Cogn. Remediat. J.

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Neuropsychiatric symptoms are one of the factors determining quality of life among Parkinson's disease patients, but often remain underestimated by clinicians, especially in early disease stage. Objective: to study the clinical features of affective disorders and comorbid personality traits in prodrome of Parkinson's disease (PD) and their effect on treatment adherence. Materials and methods: 29 patients with PD were studied with questionnaires (Toronto alexithymia scale (TAS); Minimult personal questionnaire; DSM-IV criteria (SCID-II); Hospital anxiety and depression scale (HADS); Hamilton Scale for the Assessment of Depression (HAM-D)), and clinical-psychopathological method with objective information collection, neurological examination and neuropsychological testing. Results: Among the patients with PD, personality premorbid features cluster C were most prominent (48% patients). Affective disorders in the prodromal period of PD are dysthymia (13.7%); cyclothymia (6.8%); recurrent depressive disorder (34.4%); and single depressive episode (44.8%). Affective disorders in PD are characterized by late onset, the prevalence of anxiety, asthenic-apathetic symptoms, as well as a high level of alexithymia and somatization. We found the relationship of personality traits and adherence to therapy: the least compliant are histrionic n = 3 (10.3%) and schizotypal n = 2 (6.9%) patients. A high prevalence of dissociative reactions (55%) was noted in response to a diagnosis of PD, which is similar to cancer patients.

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“…Also, impulse control problems like punding, overeating, or other addiction-like behaviours, and mood and behavioral changes may occur, as a result of dopamine dysregulation. In DDS, patients often develop mood fluctuation such as manic-like behaviors including aggression, pathological gambling, hypersexuality, and/or compulsive gambling or shopping that may switch into a depressive episode with social withdrawal and psychomotor slowing becoming a cyclical-like mood disturbance [122].…”

Section: Parkinson's Disease Dementia (Pdd)mentioning

confidence: 99%