Can molecular imaging techniques identify biomarkers for neuropsychiatric disorders?

Bressan, Rodrigo; Shih, Ming Chi; Hoexter, Marcelo Q.; Lacerda, Acioly L.T.

doi:10.1590/s1516-44462007000200003

Cited by 16 publications

(15 citation statements)

References 2 publications

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“…Ongoing efforts in neuroimaging promise to elicit new insights into the commonalities and differences among the anxiety disorders and their respective neural circuitries. 81 In this updated review of morphometric MRI studies of anxiety disorders, we have once again verified that PTSD remains as the anxiety disorder most extensively investigated by structural neuroimaging over the last five years. In agreement with our previous review, 10 the main morphological feature detected in this disorder is a reduction of the hippocampus, [22][23][24][25][26][27] although with some degree of disagreement among studies regarding laterality and even the presence of changes.…”

Section: Discussionmentioning

confidence: 71%

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Ferrari

Busatto

McGuire

et al. 2008

Rev. Bras. Psiquiatr.

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Objective: The aim of the present report is to present a systematic and critical review of the more recent literature data about structural abnormalities detected by magnetic ressonance in anxiety disorders. Method: A review of the literature in the last five years was conducted by a search of the Medline, Lilacs and SciELO indexing services using the following key words : "anxiety", "panic", "agoraphobia", "social anxiety", "posttraumatic" and "obsessive-compulsive", crossed one by one with "magnetic resonance", "voxel-based", "ROI" and "morphometry palavras-chave: "anxiety", "panic", "agoraphobia", "social anxiety", "posttraumatic" e "obsessive-compulsive" cruzadas uma a uma com "magnetic ressonance", "voxel-based", "ROI" e "morphometry

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Section: Discussionmentioning

confidence: 71%

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Ferrari

Busatto

McGuire

et al. 2008

Rev. Bras. Psiquiatr.

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“…We recently reviewed data on molecular imaging techniques in patients with genetic forms of PD (PARK1, 2, 6, 7 and 8) and clinically unclear cases of parkinsonism [19][20][21] . Neuroimaging data on PARK2 and PARK8 patients show a pattern similar to the sporadic forms of PD, except for post-synaptic involvement with greater DAT loss in the early stages of disease and slower progression in PARK2 patients.…”

Section: Discussionmentioning

confidence: 99%

Clinical and molecular neuroimaging characteristics of Brazilian patients with Parkinson's disease and mutations in PARK2 or PARK8 genes

Barsottini

Felı́cio

Aguiar

et al. 2009

Arq. Neuro-Psiquiatr.

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-Objective:To describe clinical and neuroimaging (SPECT) characteristics of Brazilian patients with Parkinson's disease (PD) and mutations in PARK2 or PARK8 genes. Method: A total of 119 patients meeting clinical criteria for PD were evaluated. Results: Of all patients studied, 13 had mutations in either PARK2 (n=9) or PARK8 genes (n=4). No statistically significant differences in clinical characteristics in both groups were seen. SPECT with [ 99m Tc] TRODAT-1 showed significant differences between patient and control and the most remarkable difference was between PARK2 and control. Conclusion: The study found a frequency of mutation of 10.1% and it was most commonly seen in women. These patients had long disease course and high rates of dyskinesia after L-DOPA use. PARK8 patients did not have a relevant family history of PD.KEY WORDS: Parkinson's disease, PARK2, PARK8, SPECT. Características clínicas e de neuroimagem molecular de pacientes brasileiros com doença de parkinson e mutações nos genes PARK2 ou PARK8Resumo -Objetivo: Descrever as características clínicas e de neuroimagem (SPECT) de pacientes brasileiros com doença de Parkinson e mutações PARK2 e PARK8. Método: Foram avaliados 119 pacientes com critérios clínicos para a doença de Parkinson. Resultados: Entre os pacientes avaliados foram encontrados 13 pacientes com mutação nos genes PARK2 (n=9) ou PARK8 (n=4). Não houve diferença significativa na avaliação das características clínicas entre os dois grupos. Os resultados de SPECT mostraram diferenças significativas quanto ao potencial de ligação do [ 99m Tc] TRODAT-1 SPECT entre pacientes vs. controle, sendo a diferença mais pronunciada entre PARK2 e controle. Conclusão: A freqüência de mutação encontrada foi 10,1%, sendo mais comum em mulheres. Estes pacientes apresentavam longo tempo de doença e alta prevalência de discinesias associadas ao uso da levodopa. Nossos pacientes com PARK8 não apresentaram uma história familiar relevante de doença de Parkinson. Parkinson' s disease (PD) is a chronic neurodegenerative disease affecting mostly patients over the age of 50 (lateonset PD or LOPD) and it has a prevalence of 1 to 3% in patients in their seventies or more 1 . PD is characterized by motor and non-motor symptoms that first develop as a result of loss of dopaminergic neurons in the substancia nigra pars compacta in the mesencephalon. As for its etiology, it has been proposed a complex interaction between environmental and toxic factors, genetic predisposition and age 2,3 . PD pathogenesis may involve dysfunction of proteasome-ubiquitin and mitochondrial system that triggers a cascade of events leading to dopaminergic loss, which is a distinctive trait of this disease 4 . Environmental factors including well water drinking, living in rural areas, exposure to pesticides, herbicides and organic solvents have been implicated in the etiology of PD 5 . We describe the main clinical findings of Brazilian patients with genetically defined PD with mutations in PARK2 or PARK8 genes as well as some mole...

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“…1 However, in contrast to the growing evidence of a biological basis for OCD, there is still limited knowledge regarding its etiology, patterns of cognitive functioning and neurochemical mechanisms. 2 New genetic and neuroimaging techniques, such as genome wide scans, structural and functional magnetic resonance imaging (MRI), as well as molecular imaging single photon emission computed tomography (SPECT) and positron emission tomography (PET) 3 are important tools that can help to clarify the pathophysiology of OCD. Such knowledge will allow the identification of individuals at early risk for OCD, the development of novel treatment strategies, as well as the ability to predict response to different interventions.…”

Section: Introductionmentioning

confidence: 99%

The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description

Hoexter

Shavitt

D’Alcante

et al. 2009

Rev. Bras. Psiquiatr.

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Can molecular imaging techniques identify biomarkers for neuropsychiatric disorders?

Cited by 16 publications

References 2 publications

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Structural magnetic ressonance imaging in anxiety disorders: an update of research findings

Clinical and molecular neuroimaging characteristics of Brazilian patients with Parkinson's disease and mutations in PARK2 or PARK8 genes

The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description

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