The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description

Hoexter, Marcelo Q.; Shavitt, Roseli Gedanke; D’Alcante, Carina Chaubet; Cecconi, Janaina Philippi; Diniz, Juliana Belo; Belotto-Silva, Cristina; Hounie, Ana Gabriela; Borcato, Sonia; Moraes, Ivanil; Joaquim, Marines; Cappi, Carolina; Sampaio, Aline Santos; Mathis, Maria Alice de; Batistuzzo, Marcelo C.; Lopes, Antônio Carlos; Rosa, Ana Carolina Ferreira; Muniz, Renan Rosetti; Marques, Andrea Horvath; Santos, Luis; Taub, Anita; Duran, Fábio Luís de Souza; Dougherty, Darin D.; Busatto, Geraldo F.; Bressan, Rodrigo A.; Miguel, Eurí­pedes Constantino

doi:10.1590/s1516-44462009000400011

Cited by 19 publications

(15 citation statements)

References 28 publications

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“…The present study focused on the most significant and nominally significant genes associated with OCD as inclusion criteria by cross-referencing these publications with GWAS and meta-analyzed genetic association (Azzam and Mathews, 2003;Lin, 2007;Pooley et al, 2007;Stewart et al, 2013aStewart et al, , 2013bTaylor, 2013;Walitza et al, 2014b). A publication by Hoexter et al (2009) was not included in the review because it did not include genetic association results in addition to their findings of single-photon emission computed tomography or magnetic resonance imaging in OCD. This particular publication describes the protocol of an ongoing study of treatment response to either a selective serotonin reuptake inhibitor (fluoxetine) or cognitive behavioral therapy compared with controls, in which the authors plan to combine findings generated from genetics (variable number of tandem repeats in the 3 0 -UTR of the dopamine transporter/SLC6A3), neuropsychology, structural magnetic resonance imaging, and molecular neuroimaging of the dopamine transporter (Hoexter et al, 2009).…”

Section: Resultsmentioning

confidence: 99%

“…A publication by Hoexter et al (2009) was not included in the review because it did not include genetic association results in addition to their findings of single-photon emission computed tomography or magnetic resonance imaging in OCD. This particular publication describes the protocol of an ongoing study of treatment response to either a selective serotonin reuptake inhibitor (fluoxetine) or cognitive behavioral therapy compared with controls, in which the authors plan to combine findings generated from genetics (variable number of tandem repeats in the 3 0 -UTR of the dopamine transporter/SLC6A3), neuropsychology, structural magnetic resonance imaging, and molecular neuroimaging of the dopamine transporter (Hoexter et al, 2009). Table 1 summarizes all imaging-genetic findings regarding genes associated with OCD.…”

Section: Resultsmentioning

confidence: 99%

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Imaging genetics in obsessive-compulsive disorder: Linking genetic variations to alterations in neuroimaging

Grünblatt

Hauser

Walitza

2014

Progress in Neurobiology

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Obsessive-compulsive disorder (OCD) occurs in ∼1-3% of the general population, and its often rather early onset causes major disabilities in the everyday lives of patients. Although the heritability of OCD is between 35 and 65%, many linkage, association, and genome-wide association studies have failed to identify single genes that exhibit high effect sizes. Several neuroimaging studies have revealed structural and functional alterations mainly in cortico-striato-thalamic loops. However, there is also marked heterogeneity across studies. These inconsistencies in genetic and neuroimaging studies may be due to the heterogeneous and complex phenotypes of OCD. Under the consideration that genetic variants may also influence neuroimaging in OCD, researchers have started to combine both domains in the field of imaging genetics. Here, we conducted a systematic search of PubMed and Google Scholar literature for articles that address genetic imaging in OCD and related disorders (published through March 2014). We selected 8 publications that describe the combination of imaging genetics with OCD, and extended it with 43 publications of comorbid psychiatric disorders. The most promising findings of this systematic review point to the involvement of variants in genes involved in the serotonergic (5-HTTLPR, HTR2A), dopaminergic (COMT, DAT), and glutamatergic (SLC1A1, SAPAP) systems. However, the field of imaging genetics must be further explored, best through investigations that combine multimodal imaging techniques with genetic profiling, particularly profiling techniques that employ polygenetic approaches, with much larger sample sizes than have been used up to now.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Imaging genetics in obsessive-compulsive disorder: Linking genetic variations to alterations in neuroimaging

Grünblatt

Hauser

Walitza

2014

Progress in Neurobiology

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“…This project was conducted in our outpatient OCD clinics at the University of São Paulo Medical School, Brazil (protocol, training, and reliability of instruments can be found elsewhere) (Hoexter et al, 2009;Miguel et al, 2008).…”

Section: Subjectsmentioning

confidence: 99%

“…From 623 patients referred to our OCD clinic from 2006 to 2008 (Hoexter et al, 2009), 254 were excluded in the telephone screening and 328 were excluded in the psychiatric medical assessment mainly for not being treatment naive (Supplementary Figure S1). In all, 41 OCD patients participated.…”

Section: Subjectsmentioning

confidence: 99%

“…The Y-BOCS (Goodman et al, 1989), Dimensional Yale-Brown Obsessive-Compulsive Scale (DY-BOCS) (Rosario-Campos et al, 2006), Beck Depression Inventory (BDI) (Beck et al, 1961), Beck Anxiety Inventory (BAI) (Beck et al, 1988), and Clinical Global Impression scale (CGI) (Guy, 1976) were administered before and after 12 weeks of treatment (Hoexter et al, 2009) by interviewers who were blind to the type of treatment.…”

Section: Clinical Assessmentsmentioning

confidence: 99%

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Gray Matter Volumes in Obsessive-Compulsive Disorder Before and After Fluoxetine or Cognitive-Behavior Therapy: A Randomized Clinical Trial

Hoexter

Duran

D’Alcante

et al. 2011

Neuropsychopharmacol

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110

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Serotonin reuptake inhibitors and cognitive-behavior therapy (CBT) are considered first-line treatments for obsessive-compulsive disorder (OCD). However, little is known about their modulatory effects on regional brain morphology in OCD patients. We sought to document structural brain abnormalities in treatment-naive OCD patients and to determine the effects of pharmacological and cognitive-behavioral treatments on regional brain volumes. Treatment-naive patients with OCD (n=38) underwent structural magnetic resonance imaging scan before and after a 12-week randomized clinical trial with either fluoxetine or group CBT. Matched-healthy controls (n=36) were also scanned at baseline. Voxel-based morphometry was used to compare regional gray matter (GM) volumes of regions of interest (ROIs) placed in the orbitofrontal, anterior cingulate and temporolimbic cortices, striatum, and thalamus. Treatment-naive OCD patients presented smaller GM volume in the left putamen, bilateral medial orbitofrontal, and left anterior cingulate cortices than did controls (p<0.05, corrected for multiple comparisons). After treatment with either fluoxetine or CBT (n=26), GM volume abnormalities in the left putamen were no longer detectable relative to controls. ROI-based within-group comparisons revealed that GM volume in the left putamen significantly increased (p<0.012) in fluoxetine-treated patients (n=13), whereas no significant GM volume changes were observed in CBT-treated patients (n=13). This study supports the involvement of orbitofronto/cingulo-striatal loops in the pathophysiology of OCD and suggests that fluoxetine and CBT may have distinct neurobiological mechanisms of action.

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Body checking and obsessive–compulsive symptoms in Brazilian outpatients with eating disorders

et al. 2014

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The drug-naïve OCD patients imaging genetics, cognitive and treatment response study: methods and sample description

Cited by 19 publications

References 28 publications

Imaging genetics in obsessive-compulsive disorder: Linking genetic variations to alterations in neuroimaging

Imaging genetics in obsessive-compulsive disorder: Linking genetic variations to alterations in neuroimaging

Gray Matter Volumes in Obsessive-Compulsive Disorder Before and After Fluoxetine or Cognitive-Behavior Therapy: A Randomized Clinical Trial

Body checking and obsessive–compulsive symptoms in Brazilian outpatients with eating disorders

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