Validity of a frustration-induction procedure

Henna, Elaine; Zilberman, Monica L.; Gentil, Valentim; Gorenstein, Clarice

doi:10.1590/s1516-44462006005000057

Cited by 10 publications

(7 citation statements)

References 13 publications

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“…Omission of expected reward has aversive properties (Amsel, 1958; Huston et al, 2013; Papini, 2003), which increase stress (Dantzer et al, 1980; Zimmerman and Koene, 1998) and anxiety-like behaviors (Komorowski et al, 2012; Manzo et al, 2014) in both experimental animals and humans (Henna et al, 2008; Papini, 2003; Yu et al, 2014). Consistent with this, rats in the reward omitted group spent less time in the center of an open field (Figure 1D) or in the open arms of an elevated plus maze (Figure 1E), when tested immediately following the Day 4 test.…”

Section: Resultsmentioning

confidence: 99%

Thalamic Regulation of Sucrose Seeking during Unexpected Reward Omission

Monte

Minier-Toribio

Quiñones-Laracuente

et al. 2017

Neuron

152

197

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SUMMARY The paraventricular nucleus of the thalamus (PVT) is thought to regulate behavioral responses under emotionally arousing conditions. Reward-associated cues activate PVT neurons, however, the specific PVT efferents regulating reward-seeking remain elusive. Using a cued sucrose-seeking task, we manipulated PVT activity under two emotionally distinct conditions: 1) when reward was available during the cue as expected, or 2) when reward was unexpectedly omitted during the cue. Pharmacological inactivation of the anterior PVT (aPVT), but not the posterior PVT, increased sucrose-seeking only when reward was omitted. Consistent with this, photoactivation of aPVT neurons abolished sucrose-seeking, and the firing of aPVT neurons differentiated reward availability. Photoinhibition of aPVT projections to the nucleus accumbens or to the amygdala increased or decreased, respectively, sucrose-seeking only when reward was omitted. Our findings suggest that PVT bidirectionally modulates sucrose-seeking under the negative (frustrative) conditions of reward omission.

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Section: Resultsmentioning

confidence: 99%

Thalamic Regulation of Sucrose Seeking during Unexpected Reward Omission

Monte

Minier-Toribio

Quiñones-Laracuente

et al. 2017

Neuron

152

197

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“…Mice exposed to the frustrating event also showed enhanced aggressive behaviour in the resident-intruder test. Aggressiveness-related feelings are a well-known consequence of frustration in humans (Henna et al 2008;Nummenmaa & Niemi 2004).…”

Section: Discussionmentioning

confidence: 99%

“…In animals, the omission of reinforcement after exposure to consistent reinforcement creates a state of frustration that can be measured in subsequent performance (Mackintosh 1974). Human subjects prevented from reaching expected rewards show affective alterations that include aggressiveness, irritability and anxiety (Henna et al 2008). These negative emotional states following frustration may have an important impact on subsequent consumption in drug addicts or patients suffering from food eating disorders.…”

Section: Introductionmentioning

confidence: 99%

Operant model of frustrated expected reward in mice

et al. 2012

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One aspect of the addictive process that has not been thoroughly investigated is the consequence of the frustrated state occurring when the drug is not available. The present study aimed to validate a novel operant model of frustrated expected reward in mice.C57BL/6J mice were trained in operant conditioning maintained by chocolate-flavoured pellets or cocaine. After the completion of high rates of responding on a progressive ratio schedule, the reward was unexpectedly withheld. The consequences of this frustrated behaviour on anxiety, aggressiveness, perseveration, extinction and reinstatement were investigated. Mice exposed to the frustrated event perseverated in the operant responses and showed increased aggressiveness in the resident-intruder test.These animals also showed higher rates of cue-induced reinstatement of drug-seeking.The present study provides a reliable operant model in mice to evaluate a frustrated state following reward unavailability. This animal model could be useful to study the behavioural and neurochemical consequences related to the emotional states generated during the omission of a highly expected reward.

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“…Enrichment with toys has been previously found to positively affect both physiological (i.e., diminution of cortisol level) and behavioral responses (i.e., increase of normal behaviors) in nonhuman primates (Boinski, Swing, Gross, & Davis, ). Delays in receiving food as well as teasing were used to induce negative emotional states, where some level of frustration most likely was experienced during the waiting (Miller & Karniol, ; Mischel, Ebbesen, & Zeiss, ), which may have even escalated into anger (Henna, Zilberman, Gentil, & Gorenstein, ). The toy, tickling, food delay, and teasing conditions were preceded by a neutral baseline, where each subject was in a relaxed state.…”

Section: Introductionmentioning

confidence: 99%

Infrared thermal imaging: Positive and negative emotions modify the skin temperatures of monkey and ape faces

Chotard

Ioannou

Davila‐Ross

2018

American J Primatol

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Facial thermography has enabled researchers to noninvasively and continuously measure the changes of a range of emotional states in humans. The present work used this novel technology to study the effect of positive and negative emotions in nonhuman primates by focusing on four facial areas (the peri-orbital area, the nose bridge, the nose tip, and the upper lip). Monkeys and apes were examined for positive emotions (during interactions with toys and during tickling) and for negative emotions (during food delay and teasing). For the combined toy and tickling condition, the results indicated a drop in the nose tip temperature and a tendency of an increase in the peri-orbital temperature. For the combined food delay and teasing condition, the results also revealed a rise in the upper lip temperature of the subjects. These different effects on the facial temperatures in monkeys and apes most likely reflect distinctive physiological reactions of a primordial primate emotion system. We conclude that facial thermal imaging represents a promising physiologically grounded technology to noninvasively and continuously obtain reliable data on emotional states in nonhuman primates, which may help modernize research on emotions in nonhuman primates and enhance our understanding of the evolution of human emotions.

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Validity of a frustration-induction procedure

Cited by 10 publications

References 13 publications

Thalamic Regulation of Sucrose Seeking during Unexpected Reward Omission

Thalamic Regulation of Sucrose Seeking during Unexpected Reward Omission

Operant model of frustrated expected reward in mice

Infrared thermal imaging: Positive and negative emotions modify the skin temperatures of monkey and ape faces

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