Association study between the 1287 A/G exonic polymorphism of the norepinephrine transporter (NET) gene and obsessive-compulsive disorder in a Brazilian sample

Miguita, Karen; Cordeiro, Quirino; Shavitt, Roseli Gedanke; Miguel, Eurí­pedes Constantino; Vallada, Homero

doi:10.1590/s1516-44462006000200017

Cited by 9 publications

(5 citation statements)

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“…Miguita et al investigated the 1287 A/G NET and VNTR DAT1 polymorphisms; however, they did not find an association with OCD. 45,46 Based on the several lines of evidence supporting an immunologic involvement on OCD etiopathogenesis, Hounie et al investigated polymorphisms of the promoter region of the TNF-alpha gene and association of the -308 G/A and -238 G/A polymorphisms with the disorder. 47 The Program of the ObsessiveCompulsive Spectrum Disorders (PROTOC) at the Universidade de São Paulo Medical School has conducted genetic studies on families.…”

Section: Research Groups and Their Main Findings In The Brazilian Popmentioning

confidence: 99%

A review of psychiatric genetics research in the Brazilian population

Cordeiro

Souza

Corrêa

et al. 2009

Rev. Bras. Psiquiatr.

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Section: Research Groups and Their Main Findings In The Brazilian Popmentioning

confidence: 99%

A review of psychiatric genetics research in the Brazilian population

Cordeiro

Souza

Corrêa

et al. 2009

Rev. Bras. Psiquiatr.

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“…Two genes that connect milnacipran and OCD are the norepinephrine transporter SLC6A2 and the serotonin transporter SLC6A4 ( Figure 5b ). Milnacipran, SLC6A2 and SLC6A4 are linked in literature by studies that report on the inhibitory effect of milnacipran on norepinephrine and serotonin uptake [47] , [48] , whereas susceptibility to OCD was linked in literature to polymorphisms in SLC6A4 and SLC6A2 [49] , [50] . These reports underpin a functional relationship between milnacipran and OCD, and shows that the predicted relationship between milnacipran and OCD by CoPub Discovery can be well explained by the biology of the intermediates.…”

Section: Resultsmentioning

confidence: 99%

Literature Mining for the Discovery of Hidden Connections between Drugs, Genes and Diseases

Frijters

Vugt²,

Smeets³

et al. 2010

PLoS Comput Biol

145

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The scientific literature represents a rich source for retrieval of knowledge on associations between biomedical concepts such as genes, diseases and cellular processes. A commonly used method to establish relationships between biomedical concepts from literature is co-occurrence. Apart from its use in knowledge retrieval, the co-occurrence method is also well-suited to discover new, hidden relationships between biomedical concepts following a simple ABC-principle, in which A and C have no direct relationship, but are connected via shared B-intermediates. In this paper we describe CoPub Discovery, a tool that mines the literature for new relationships between biomedical concepts. Statistical analysis using ROC curves showed that CoPub Discovery performed well over a wide range of settings and keyword thesauri. We subsequently used CoPub Discovery to search for new relationships between genes, drugs, pathways and diseases. Several of the newly found relationships were validated using independent literature sources. In addition, new predicted relationships between compounds and cell proliferation were validated and confirmed experimentally in an in vitro cell proliferation assay. The results show that CoPub Discovery is able to identify novel associations between genes, drugs, pathways and diseases that have a high probability of being biologically valid. This makes CoPub Discovery a useful tool to unravel the mechanisms behind disease, to find novel drug targets, or to find novel applications for existing drugs.

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“…Rs5522 was selected due to its past association with enhanced physiological stress response and reduced cortisol-induced MR gene expression, two components which can be associated to psychopathy (R. Bogdan, Perlis, Fagerness, & Pizzagalli, 2010). Alternatively, rs5569 was selected as it is one of the most common SNP studied when examining the SLC6A2 gene (Bruxel et al, 2014;Miguita, Cordeiro, Shavitt, Miguel, & Vallada, 2006;Retz et al, 2008;Sun et al, 2008)…”

Section: Considering the Supposed Relationship Between Ne And Mr On Pmentioning

confidence: 99%

Peer Review #2 of "Influence of allelic variations in relation to norepinephrine and mineralocorticoid receptors on psychopathic traits: a pilot study (v0.1)"

2018

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Background. Past findings support a relationship between abnormalities in the amygdala and the presence of psychopathic traits. Among other genes and biomarkers relevant to the amygdala, norepinephrine and mineralocorticoid receptor might both play a role in psychopathy due to their association with traits peripheral to psychopathy. The purpose is to examine if allelic variations in single nucleotide polymorphisms related to norepinephrine and mineralocorticoid receptor play a role in the display of psychopathic traits and executive functions. Methods. Fifty-seven healthy participants from the community provided a saliva sample for SNP sampling of rs5522 and rs5569. Participants then completed the Psychopathic Personality Inventory-Short Form (PPI-SF) and the Tower of Hanoi. Results. Allelic variations of both rs5522 and rs5569 were significant when compared to PPI-SF total score and the fearless dominance component of the PPI-SF. A significant result was also obtained between rs5522 and the number of moves needed to complete the 5-disk Tower of Hanoi. Conclusion. This pilot study offers preliminary results regarding the effect of allelic variations in SNPs related to norepinephrine and mineralocorticoid receptor on the presence of psychopathic traits. Suggestions are provided to enhance the reliability and validity of a larger-scale study.

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Association study between the 1287 A/G exonic polymorphism of the norepinephrine transporter (NET) gene and obsessive-compulsive disorder in a Brazilian sample

Abstract: Cartas aos editores 2.Jochum T, Bar KJ, Sauer H. Topiramate induced manic episode.

Cited by 9 publications

References 1 publication

A review of psychiatric genetics research in the Brazilian population

A review of psychiatric genetics research in the Brazilian population

Literature Mining for the Discovery of Hidden Connections between Drugs, Genes and Diseases

Peer Review #2 of "Influence of allelic variations in relation to norepinephrine and mineralocorticoid receptors on psychopathic traits: a pilot study (v0.1)"

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