Disease outbreaks do not only create health challenges; they also potentially affect public health communication. To complement the efforts of medical and health workers, health communication professionals often try to design semiotic resources to advance the goal of health and medical practice. This chapter, therefore, explores the various semiotic resources created with the aid of digital technologies and deployed by the Nigeria Center for Disease Control across digital platforms to combat the COVID-19 pandemic. Applying Kress and van Leeuwen's social semiotic theory to 12 NCDC images sourced online, the chapter demonstrates that the semiotic resources shared by the NCDC on hygiene practices to fight COVID-19 have the potential of broadening the scope of interpretation, meaning, and understanding of COVID-19, health problems, and medical practices on account of the texts' representational, interactional, and compositional structures, thereby helping in building a vibrant healthcare system in Nigeria.