Genética do transtorno bipolar

Michelon, Leandro; Vallada, Homero

doi:10.1590/s1516-44462004000700004

Cited by 10 publications

(4 citation statements)

References 49 publications

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“…It has been confirmed by various studies that this disorder possess high range of heritability and there could be many potential candidate gene that is dysregulated during development and can lead to the progression of schizophrenia symptoms (Fatemi and Folsom 2009;Holmans et al 2009). In the current years, progress in neuroimaging, molecular biology and genetic techniques has provided new insights into the biology of schizophrenia (Michelon and Vallada 2004). There are innumerable reports of genes and various new loci that have been recognized to be associated with the disorder however, genetic research aiming efficient characterization of SCZ is needed that can help in very early stage detection of endophenotypes, identifying parents that have schizophrenic descendants and identifying the schizophrenia patients that are unresponsive to anti-psychotic medication.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: A review of 45 candidate genes: Association of single nucleotide polymorphism to schizophrenia Risk

Priya

Sharma

et al. 2018

New Genetics and Society

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Schizophrenia (SCZ) is a serious mental disorder that has complex genetic architecture. It has complex mode of transmission and inheritance which is associated with environmental, developmental and genetic set off. It is a strong heritable disorder that involves multiple gene combination, each conferring a little increase in the burden to the disease. Due to the complexity of disease, it is difficult to find susceptible genes and promising biomarker. The true etiology of SCZ is still not fully understood, however, recent studies on SCZ molecular genetics, with a focus on candidate genes approach affirms and predicate association with SCZ. Some investigators have reported the involvement of environmental factors in the formation and progression of the Schizophrenia. Literature has been surveyed that reports the association between genetic variation and SCZ also between genetic polymorphisms and clinical outcomes. The present study focuses on human populations to review SNPs of various genes which show best association with the disease. We have identified 60 published case control studies that have studied association of various SNPs in different population.

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Section: Introductionmentioning

confidence: 99%

RETRACTED ARTICLE: A review of 45 candidate genes: Association of single nucleotide polymorphism to schizophrenia Risk

Priya

Sharma

et al. 2018

New Genetics and Society

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“…It has been confirmed by various studies that this disorder possess high range of heritability and there could be many potential candidate gene that are dysregulated during development and can lead to the progression of schizophrenia symptoms [3,4]. In the current years, progress in neuroimaging, molecular biology and genetic techniques has provided new insights into the biology of schizophrenia [5]. There are innumerable reports of genes and various new loci that have been recognized to be associated with the disorder however, genetic research aiming efficient characterization of SCZ is needed that can help in very early stage detection of endophenotypes, identifying parents that have schizophrenic descendants and identifying the schizophrenia patients that are unresponsive to antipsychotic medication.…”

Section: Introductionmentioning

confidence: 96%

A review of potential candidate genes polymorphism responsible for schiz-ophrenia risk

Priya¹,

Sharma²,

Sharma³

et al. 2019

IJSRBS

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Schizophrenia (SCZ) is a strong heritable disorder that involves multiple gene combination, each conferring a little increase in the burden to the disease. Due to the complexity of disease, it is difficult to find susceptible genes and promising biomarker. The true etiology of SCZ is still not fully understood, however, recent studies on SCZ molecular genetics, with a focus on candidate genes approach affirms and predicate association with SCZ. Some investigators have reported the involvement of environment factors in the formation and progression of the Schizophrenia. Literature has been surveyed that reports association between genetic variation and SCZ also between genetic polymorphisms and clinical outcomes. The present study focuses on human populations to review SNPs of various genes which show best association with the disease. We have identified 60 published case control studies that have studied association of various SNPs in different population.

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“…In the recent years, advances on techniques of neuroimaging, molecular biology and genetics has provided new insights about the biology of bipolarity 7 . Several studies have identified genes that are associated with triggering BD.…”

Section: Introductionmentioning

confidence: 99%

Associação entre polimorfismos genéticos e transtorno bipolar

Alves¹,

Silva²,

Neto³

et al. 2012

Rev. psiquiatr. clín.

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Bipolar disorder (BD) is a common disorder that affects approximately 1% of the population. It is associated with both chronic and acute severe features, such as low remission rates and a high prevalence of clinical and psychiatric comorbidities. The aim of the present article is to synthesize data from various articles that investigated genetic polymorphisms associated with BD. The 129 articles selected identified 79 (85.87%) genes associated with BD. This analysis identified the five genes that are the most cited in the literature: CANAC1C, DAOA, TPH2, ANK3 and DISC1. Of the 92 genes identified in these articles, 33 (35.87%) showed no association with BD. This analysis showed that, despite recent advances with respect to the role of genetic polymorphism in predisposition to BD, further research is still required to elucidate its influence on this disorder.Alves VM, et al. / Rev Psiq Clín. 2012;39(1):34-9 Keywords: Bipolar disorder, genes, polymorphisms, heredity, gene ontology, association with bipolar disorder. ResumoTranstorno bipolar (TB) é uma doença comum que afeta aproximadamente 1% da população. Apresenta características crônicas e agudas graves, com índices de remissão de baixa e alta prevalência de comorbidades clínicas e psiquiátricas. O objetivo do presente artigo é sintetizar dados de vários artigos que investigaram polimorfismos genéticos associados com TB. Dentre os 129 artigos selecionados, identificaram-se 79 (85,87%) genes associados com TB. Essa análise identificou cinco genes que são os mais citados na literatura: CANAC1C, DAOA, TPH2, ANK3 e DISC1. Dos 92 genes identificados nesses artigos, 33 (35,87%) não mostraram associação com TB. Essa análise mostrou que, apesar dos avanços recentes com relação ao papel do polimorfismo genético na predisposição para TB, mais pesquisas ainda são necessárias para elucidar sua influência sobre esse transtorno.Alves VM, et al. / Rev Psiq Clín. 2012;39(1):34-9 Palavras-chave: Transtorno bipolar, genes, polimorfismos, hereditariedade, ontologia genética, associação com transtorno bipolar.

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Genética do transtorno bipolar

Cited by 10 publications

References 49 publications

RETRACTED ARTICLE: A review of 45 candidate genes: Association of single nucleotide polymorphism to schizophrenia Risk

RETRACTED ARTICLE: A review of 45 candidate genes: Association of single nucleotide polymorphism to schizophrenia Risk

A review of potential candidate genes polymorphism responsible for schiz-ophrenia risk

Associação entre polimorfismos genéticos e transtorno bipolar

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