Métodos de neuroimagem e abuso de substâncias psicoativas

Nicastri, Sérgio

doi:10.1590/s1516-44462001000500009

Cited by 8 publications

(7 citation statements)

References 19 publications

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“…The alterations in Cb resulting from chronic cocaine use have been correlated with its relationship and the maintenance of drug memory. However, despite the evidence of higher cerebellar activation in studies with cocaine, this mechanism is still unclear (Jiménez-Rivera et al, 2000 ; Nicastri, 2001 ; Carbo-Gas et al, 2014 ; López-Pedrajas et al, 2015 ; Vazquez-Sanroman et al, 2015 ). Cb neurons and glia are arranged in layers.…”

Section: Discussionmentioning

confidence: 99%

Single Low Dose of Cocaine–Structural Brain Injury Without Metabolic and Behavioral Changes

et al. 2021

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Chronic cocaine use has been shown to lead to neurotoxicity in rodents and humans, being associated with high morbidity and mortality rates. However, recreational use, which may lead to addictive behavior, is often neglected. This occurs, in part, due to the belief that exposure to low doses of cocaine comes with no brain damage risk. Cocaine addicts have shown glucose metabolism changes related to dopamine brain activity and reduced volume of striatal gray matter. This work aims to evaluate the morphological brain changes underlying metabolic and locomotor behavioral outcome, in response to a single low dose of cocaine in a pre-clinical study. In this context, a Balb-c mouse model has been chosen, and animals were injected with a single dose of cocaine (0.5 mg/kg). Control animals were injected with saline. A behavioral test, positron emission tomography (PET) imaging, and anatomopathological studies were conducted with this low dose of cocaine, to study functional, metabolic, and morphological brain changes, respectively. Animals exposed to this cocaine dose showed similar open field activity and brain metabolic activity as compared with controls. However, histological analysis showed alterations in the prefrontal cortex and hippocampus of mice exposed to cocaine. For the first time, it has been demonstrated that a single low dose of cocaine, which can cause no locomotor behavioral and brain metabolic changes, can induce structural damage. These brain changes must always be considered regardless of the dosage used. It is essential to alert the population even against the consumption of low doses of cocaine.

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Section: Discussionmentioning

confidence: 99%

Single Low Dose of Cocaine–Structural Brain Injury Without Metabolic and Behavioral Changes

et al. 2021

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“…Diversos autores referem-se às crescentes preocupações com relação ao uso e abuso de drogas nos últimos anos do século XX (BENTO, 1993;BERTOLUCCI, 2003;BIRMAN, 1999BIRMAN, , 2003BITTENCOURT, 2003;ULHOA;LONGO, 1981;COSTA, 1985;CAGLAR, 1981;COSTA, 2001;GSCHWEND;SIEBER, 1981;LIMA, 2001;MOREL;HERVÉ;FONTAINE, 1997;BERTOLUCCI, 2003;NICASTRI, 2003;OLIEVENSTEIN, 1988;SILVA, 1991;SILVEIRA FILHO, 1995;SIMON, 1985;SIPAHI;VIANNA, 2002;VALLEUR;MATYSIAK, 2006). No entanto, as preocupações relativas ao tema aparecem desde os tempos de Freud, que, embora não tenha se dedicado especificamente sobre o assunto, tece algumas considerações a esse respeito ao longo de sua obra.…”

Section: Algumas Abordagensunclassified

Do psicodiagnóstico à intervenção em adictos: contribuições do Rorschach e do atendimento clínico

Kallas¹

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“…Os estudos de fluxo sangüíneo revelam a participação das porções pré e órbito-frontais nas funções executivas e especificamente o córtex pré-frontal dorsolateral nas tarefas de planejamento (Bolla et al, 2003). Entretanto, estes achados devem ser tomados apenas como preliminares, considerando os profundos efeitos vasculares da cocaína (Nicastri, 2001).…”

Section: Achados Estruturaisunclassified

"Jogo patológico: análise por neuroimagem, neuropsicológica e de personalidade"

Moreira¹

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Métodos de neuroimagem e abuso de substâncias psicoativas

Cited by 8 publications

References 19 publications

Single Low Dose of Cocaine–Structural Brain Injury Without Metabolic and Behavioral Changes

Single Low Dose of Cocaine–Structural Brain Injury Without Metabolic and Behavioral Changes

Do psicodiagnóstico à intervenção em adictos: contribuições do Rorschach e do atendimento clínico

"Jogo patológico: análise por neuroimagem, neuropsicológica e de personalidade"

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