Probiotics and antibiotics as additives for sows and piglets during nursery phase

Silva, Marcus Leonardo Figueiredo; Lima, José Augusto de Freitas; Cantarelli, Vinícius de Souza; Amaral, Nikolas de Oliveira; Zangerônimo, Márcio Gilberto; Fialho, Elias Tadeu

doi:10.1590/s1516-35982010001100019

Cited by 13 publications

(9 citation statements)

References 14 publications

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“…In conclusion, these findings highlighted the crucial role of Ba in enhancing the antioxidant capacity of piglets via activating Nrf2 signaling pathway and intestinal autophagy. Although the control group without antibiotics and Ba was absent in our study, negative control was also not included in some researches evaluating the effects of probiotics as antibiotic substitutes (Kritas and Morrison 2005 ; Silva et al 2010 ). Besides, in-feed antibiotics have been proved to contribute to a 3–5% improvement in nutrient utilization, a 3–8% improvement in growth rate, and a 2–5% improvement in feed conversion efficiency (Close 2000 ).…”

Section: Discussionmentioning

confidence: 98%

Effects of probiotic Bacillus as a substitute for antibiotics on antioxidant capacity and intestinal autophagy of piglets

Wang

et al. 2017

AMB Expr

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The objective of this study was to evaluate effects of probiotic Bacillus amyloliquefaciens (Ba) as a substitute for antibiotics on growth performance, antioxidant ability and intestinal autophagy of piglets. Ninety piglets were divided into three groups: G1 (containing 150 mg/Kg aureomycin in the diet); G2 (containing 75 mg/Kg aureomycin and 1 × 108 cfu/Kg Ba in the diet); G3 (containing 2 × 108 cfu/Kg Ba in the diet without any antibiotics). Each treatment had three replications of ten pigs per pen. Results showed that Ba replacement significantly increased the daily weight gain of piglets. Moreover, improved antioxidant status in serum and jejunum was noted in Ba-fed groups as compared with aureomycin group. Increased gene expression of antioxidant enzymes and elevated nuclear factor erythroid 2 related factor 2 (Nrf2) in jejunum was also observed in Ba-fed groups. Besides, Ba replacement significantly decreased jejunal c-Jun N-terminal kinase (JNK) phosphorylation compared with antibiotic group. Western blotting results also revealed that replacing all antibiotics with Ba initiated autophagy in the jejunum as evidenced by increased microtubule-associated protein 1 light chain 3 II (LC3-II) abundance. Taken together, these results indicate that replacing aureomycin with Ba can improve growth performance and antioxidant status of piglets via increasing antioxidant capacity and intestinal autophagy, suggesting a good potential for Ba as an alternative to antibiotics in feed.Electronic supplementary materialThe online version of this article (doi:10.1186/s13568-017-0353-x) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 98%

Effects of probiotic Bacillus as a substitute for antibiotics on antioxidant capacity and intestinal autophagy of piglets

Wang

et al. 2017

AMB Expr

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“…The probiotic was shown to be more efficacious than tylosin and to be as active as doxycycline–gentamicin (da Silva et al., ). Similarly, probiotic products composed by Bifidobacterium bifidum Enterococcus faecium Lactobacillus acidophilus and Lactobacillus plantarum, when added to diets for sows and piglets, showed the same effect on the incidence of diarrhoea compared to antimicrobial treatments (amoxicillin and colistin) (Silva et al., ). A study in the USA (Kritas and Morrison, ) was performed in a large pig nursery, where medication was routinely required to prevent disease and production losses, comparing antimicrobial treatments (neomycin for the first five to seven days post‐weaning; neomycin plus oxytetracycline for the next seven days, and thereafter, tylosin up to the age of 70 days) with probiotic supplementation ( Bacillus licheniformis and B. subtilis at a dose of 10 9 CFU/kg of feed).…”

Section: Assessment Of Measures To Reduce the Need For Antimicrobialsmentioning

confidence: 99%

EMA and EFSA Joint Scientific Opinion on measures to reduce the need to use antimicrobial agents in animal husbandry in the European Union, and the resulting impacts on food safety (RONAFA)

Murphy¹,

Ricci²,

Auce³

et al. 2017

EFS2

143

104

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EFSA and EMA have jointly reviewed measures taken in the EU to reduce the need for and use of antimicrobials in food-producing animals, and the resultant impacts on antimicrobial resistance (AMR). Reduction strategies have been implemented successfully in some Member States. Such strategies include national reduction targets, benchmarking of antimicrobial use, controls on prescribing and restrictions on use of specific critically important antimicrobials, together with improvements to animal husbandry and disease prevention and control measures. Due to the multiplicity of factors contributing to AMR, the impact of any single measure is difficult to quantify, although there is evidence of an association between reduction in antimicrobial use and reduced AMR. To minimise antimicrobial use, a multifaceted integrated approach should be implemented, adapted to local circumstances. Recommended options (non-prioritised) include: development of national strategies; harmonised systems for monitoring antimicrobial use and AMR development; establishing national targets for antimicrobial use reduction; use of on-farm health plans; increasing the responsibility of veterinarians for antimicrobial prescribing; training, education and raising public awareness; increasing the availability of rapid and reliable diagnostics; improving husbandry and management procedures for disease prevention and control; rethinking livestock production systems to reduce inherent disease risk. A limited number of studies provide robust evidence of alternatives to antimicrobials that positively influence health parameters. Possible alternatives include probiotics and prebiotics, competitive exclusion, bacteriophages, immunomodulators, organic acids and teat sealants. Development of a legislative framework that permits the use of specific products as alternatives should be considered. Further research to evaluate the potential of alternative farming systems on reducing AMR is also recommended. Animals suffering from bacterial infections should only be treated with antimicrobials based on veterinary diagnosis and prescription. Options should be reviewed to phase EFSA Journal 2017;15(1):4666 www.efsa.europa.eu/efsajournal out most preventive use of antimicrobials and to reduce and refine metaphylaxis by applying recognised alternative measures.

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“…Diarrhea cases were considered when the fecal score was 2 or 3. The diarrhea incidence rates for each treatment were calculated (Silva et al, 2010).…”

Section: Methodsmentioning

confidence: 99%

Calcium anacardate as growth promoter for piglets at the nursery phase

Matos

Watanabe

Freitas

et al. 2017

Pesq. agropec. bras.

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The objective of this work was to evaluate the effects of the dietary inclusion of calcium anacardate on the performance, diarrhea incidence, blood parameters, intestinal morphometry, and pH of gastrointestinal contents in piglets from 21 to 42 days of age. Sixty weaned Topigs piglets, with initial weight of 6.049±0.311 kg, were distributed in the following treatments: diet with or without antibiotic growth promoter (zinc bacitracin) and diets supplemented with increasing levels of calcium anacardate (0.4, 0.8, and 1.2%), with six replicates and two animals per experimental unit. No differences in performance (21 to 42 days of age), blood parameters, and villus height:crypt depth ratio were found between piglets fed diets containing calcium anacardate or antibiotic growth promoter. The replacement of the antibiotic growth promoter zinc bacitracin by calcium anacardate results in similar performance in piglets from 21 to 42 days of age, without changes in blood parameters and in the villus height:crypt depth ratio. The dietary inclusion of calcium anacardate does not decrease diarrhea incidence compared with the antibiotic zinc bacitracin.

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Probiotics and antibiotics as additives for sows and piglets during nursery phase

Cited by 13 publications

References 14 publications

Effects of probiotic Bacillus as a substitute for antibiotics on antioxidant capacity and intestinal autophagy of piglets

Effects of probiotic Bacillus as a substitute for antibiotics on antioxidant capacity and intestinal autophagy of piglets

EMA and EFSA Joint Scientific Opinion on measures to reduce the need to use antimicrobial agents in animal husbandry in the European Union, and the resulting impacts on food safety (RONAFA)

Calcium anacardate as growth promoter for piglets at the nursery phase

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