Relação do zinco e cobre plasmáticos com componentes nutricionais e desempenho de leitões: uma meta-análise

Abstract

RESUMO -Foi realizada uma meta-análise para estudar a relação do zinco (Zn) e cobre (Cu) plasmáticos com os nutrientes da dieta e ganho de peso em leitões. A base de dados contemplou 18 publicações. As variáveis nutricionais consideradas na análise foram ingestões de PB, lisina, Ca, P, Cu e Zn. Relation of plasma zinc and copper with nutritional components and performance of weanling pigs: a meta-analysisABSTRACT -A meta-analysis was carried out to study the relationship among plasma Zn and Cu with diet nutrients and piglets weight gain. Eighteen publications were considered in the database. The intake of CP, lysine, Ca, P, Cu and Zn was considered as variable in the analysis. Regression analyses were used through mixed models. Plasma Zn was affected by P and Zn intake as well as Cu plasma. P intake and plasma Cu affected negatively plasmatic Zn. The regression analysis showed that for each gram of total P intake/kg BW 0.6 there was reduction in 0.043 mg/L of plasmatic Zn. Plasma Cu was affected by Ca, P, Cu and Zn intake. Ca and Zn intake affected negatively plasma Cu. Weight gain was affected by CP, Ca, lysine and Cu intake as well as plasma Zn. A negative effect of Zn intake on Cu metabolism was observed; however plasma Zn had a positive effect on piglets weight gain. This meta-analysis study identified some factors of dietary origin, as P and Ca, which influence negatively the absorption and the metabolism of Zn and Cu in weanling pigs.Key Words: metabolism, micro minerals, mixed models, nutrients IntroduçãoO estudo das interações dos nutrientes no trato gastrintestinal (TGI) e no metabolismo animal tem apresentado um papel importante na evolução da nutrição dos animais. Entre os nutrientes, os microminerais representam menos de 0,02% na dieta e 0,30% no tecido animal (Mahan & Shields Jr., 1998). O Zn e Cu, embora sejam os microminerais com menor participação na composição corporal do suíno (Mahan & Shields Jr., 1998), estão envolvidos em diversas funções digestivas e metabólicas (Cousins, 1985). Existem componentes nutricionais que podem reduzir a biodisponibilidade desses microminerais na dieta, alterando a homeostasia nos tecidos. O estudo das interações desses componentes implica primariamente em conhecer o processo digestivo e metabólico desses microminerais.O metabolismo do Zn e Cu apresentam determinadas semelhanças e são regulados pelo TGI e fígado (Cousins, 1985). A absorção do Zn e Cu é regulada via hepática pela metalotioneína, proteína que mantém a homeostasia desses minerais (Cousin, 1985). No TGI, em ingestões elevadas de

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