Positivity of HIV, hepatitis B and hepatitis C in patients enrolled in a confidential self-exclusion system of blood donation: a cross-sectional analytical study

Kasraian, Leila; Tavasoli, Alireza

doi:10.1590/s1516-31802010000600002

Cited by 19 publications

(20 citation statements)

References 8 publications

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“…The fi rst CSE system was developed in the United States in 1984, and since then, similar systems have been used in several countries 22 . In Brazil, the use of CSE has been mandatory with blood donations since 2003 30,31 .…”

Section: Methods Resultsmentioning

confidence: 99%

“…Although a relationship between CSE and positive serology for viral hepatitis has been previously demontrated 22,57,61 , the ability of this practice to identify individuals in the testing window period was not previously addressed. The sensitivity and positive predictive values of CSE are quite low 22,58,[61][62][63] , leading to the disposal of many blood bags from potentially healthy donors.…”

Section: Discussionmentioning

confidence: 99%

“…The sensitivity and positive predictive values of CSE are quite low 22,58,[61][62][63] , leading to the disposal of many blood bags from potentially healthy donors. The main factors related to problems with the CSE form are the diffi culty of understanding the question 26,28,57,58 , the low socioeconomic status of the donors 58,59 , and the ineffective explanations by health professionals 58 .…”

Section: Discussionmentioning

confidence: 99%

“…Safety in blood donation is a major concern at blood transfusion centers 22 . Efforts to guarantee safety focus on ensuring a supply of suitable blood bags, selecting healthy donors, and preventing donations by individuals at an increased…”

Section: Introductionmentioning

confidence: 99%

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Positive serology for viral hepatitis and donor self-exclusion in Southern Brazil

Maccarini

Nazário

Ferreira

et al. 2013

Rev. Soc. Bras. Med. Trop.

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Introduction: Despite the great advances in serological testing for transfusion-transmitted infections, the selection of blood donors by blood bank operators remains the only way to avoid transmission within the testing window period. Part of this selection is the self-exclusion form, on which the donors can exclude their blood from donation without any explanation. This study assessed the clinical and epidemiological characteristics related to positivity for viral hepatitis and to the use of the confi dential self-exclusion (CSE) form. Methods: This transversal study analyzed the data collected from blood donors' fi les in a hospital in Southern Brazil. Univariate and multivariate analyses identifi ed the clinical and epidemiological variables related to positive serologies of viral hepatitis and to whether the donor was self-excluded. Results: Of the 3,180 donors included in this study, 0.1% tested positive for HBsAg, 2.1% for anti-HBc, and 0.9% for anti-HCV. When the 93 donors with positive serologies for viral hepatitis were compared with those who were negative, a greater proportion of the positive serology group was found to have had a history of blood transfusions (OR=4.908; 95%CI=1.628 -14.799; p<0.01), had repeatedly donated (OR=2.147; 95%CI=1.236 -3.729; p<0.01), and used the CSE form for self-exclusion (OR=7.139; 95%CI=2.045 -24.923; p<0.01). No variables were independently associated with self-exclusion. Conclusions: A history of blood transfusion, repeated donations, and self-exclusion are factors that should be considered during viral hepatitis screenings in blood banks.

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Section: Methods Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Positive serology for viral hepatitis and donor self-exclusion in Southern Brazil

Maccarini

Nazário

Ferreira

et al. 2013

Rev. Soc. Bras. Med. Trop.

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“…Moreover, various studies show the altruistic donors and women represent lower transfusion risk than replacement donors, paid donors and men. 1,3,12,14,19,23 The different institutions need to know the epidemiological behaviour of the donors in order to implement strategies which enable their continuation as well as increasing the number of altruistic donors.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalencia de marcadores de infecciones transmisibles por vía transfusional en banco de sangre de Colombia

Bedoya¹,

Márquez²,

Arias³

2012

Rev. Saúde Pública

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METHODS:A cross-sectional secondary data source, based on the results of biological testing of donors to a blood bank in Medellin. We determined the seroprevalence of markers of infection and were compared by sex and type of donor through frequency analysis, chi square, Fisher and prevalence ratios. RESULTS:The base population was 65,535 donors, and 3.3% had at least one positive biological test. The most prevalent marker in the blood bank testing was syphilis (1.2%), followed by trypanosomiasis (1.0%), hepatitis C virus (HCV) (0.6%), human immunodefi ciency virus (HIV) 0.5% and hepatitis B virus (HBV) (0.2%). Based on the reference laboratory found a prevalence of 0.6% for syphilis, 0.1% for (HBV) and 0% for (HCV), (HIV) and Chagas. We found statistical differences in the prevalence of (HBV) and syphilis by sex and type of donor. CONCLUSIONS:The results are consistent with the prevalences given by Pan American Health Organization and can be correlated with the global prevalence of transfusion-transmitted infections. The results founds by the blood bank lead to a transfusion risk reduction but limit the optimization of resources by excluding donors classifi ed as false positives.

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Confidential unit exclusion (CUE): Double edged sword for blood transfusion center: A ten-year study on volunteer blood donors in Kohgiluyeh and Boyer Ahmad province, Iran

Rad

Sajjadi

Azizi

et al. 2019

Transfusion Clinique et Biologique

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Positivity of HIV, hepatitis B and hepatitis C in patients enrolled in a confidential self-exclusion system of blood donation: a cross-sectional analytical study

Cited by 19 publications

References 8 publications

Positive serology for viral hepatitis and donor self-exclusion in Southern Brazil

Positive serology for viral hepatitis and donor self-exclusion in Southern Brazil

Seroprevalencia de marcadores de infecciones transmisibles por vía transfusional en banco de sangre de Colombia

Confidential unit exclusion (CUE): Double edged sword for blood transfusion center: A ten-year study on volunteer blood donors in Kohgiluyeh and Boyer Ahmad province, Iran

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