Confidential unit exclusion (CUE): Double edged sword for blood transfusion center: A ten-year study on volunteer blood donors in Kohgiluyeh and Boyer Ahmad province, Iran

Rad, Fariba; Sajjadi, Seyed Mehdi; Azizi, Arash; Maghsudlu, Mahtab

doi:10.1016/j.tracli.2019.05.002

Cited by 5 publications

(5 citation statements)

References 18 publications

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“…Similar to other studies, our results showed a higher prevalence of HBsAg compared to HCV in both total and firsttime donors [30,32]. This high prevalence may be due to the higher rate of HBV in the general population of this province, whereas this issue was not determined in any other study and consequently further studies are required to confirm this issue [33,34].…”

Section: Discussionsupporting

confidence: 87%

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First-Time Blood Donors are Double Edged Swords for Blood Transfusion Centers: a Retrospective Study in Southwest Iran

Niazkar¹,

Dorgalaleh²,

Rad³

2019

Tjh

Self Cite

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Objective: First-time blood donors are the most common group of blood donors. They usually have different motivations for blood donation, some of which provoke the donors to hide risk factors of transfusion-transmissible infections (TTIs). Therefore, detection of TTIs among first-time donors is crucial and can decrease the rate of TTIs among blood recipients. This study aimed to evaluate the prevalence of TTIs among first-time donors in the transfusion center of Kohgiluyeh and Boyer-Ahmad Province (KBTC), Iran. Materials and Methods:This retrospective study was conducted with volunteer blood donors in 2004-2014 in the KBTC. Various data, including sex, confidential unit exclusion (CUE), previous donation history, and the laboratory findings of confirmatory tests, were extracted from blood donor software. Data were analyzed by SPSS using the chi-square test.Results: Among 198,501 blood donors, 52,527 (26.46%) were firsttime donors, while 145,974 donors (73.54%) were repeat and regular donors. Most of the donors (94.5%) were male, while a minority (5.5%) were female. The CUE option was chosen by 2,237 (1.13%) donors. The incidence of hepatitis B surface antigen (HBsAg) and hepatitis C virus (HCV) was 247 (0.13%) and 134 (0.07%) among the entire study population, respectively. Three donors (0.002%) had confirmed human immunodeficiency virus (HIV), while none of the blood donors were positive for syphilis. Most of the donors with positive HBsAg (95.8%), HCV (86.6%), and HIV (100%) infection were first-time donors. Conclusion:Since TTIs are more common among first-time blood donors than regular and repeat donors, special considerations should be taken into account for this common group of blood donors.Amaç: Kan donörlerinin büyük çoğunluğunu ilk kez kan veren donörler oluşturmaktadır. Bu kişilerin genellikle kan vermek için farklı motivasyonları vardır ve bu da vericilerin transfüzyon ilişkili enfeksiyonları (TTI) saklaması açısından risk oluşturur. Bu nedenle ilk kez verici olanlarda TTI'ları tespit etmek çok önemlidir ve böylece kan alıcılarında TTI'lar azaltılabilir. Bu çalışmada amaç İran'da Kohgiluyeh ve Boyer-Ahmad Bölgesi (KBTC) transfüzyon merkezindeki ilk kez verici olan kan donörlerinde TTI prevelansının araştırılmasıdır. Gereç ve Yöntemler:Bu çalışma, KBTC'de 2004-2014 yılları arasında gönüllü kan vericilerinin dahil edildiği retrospektif bir çalışmadır. Cinsiyet, gizli ünite dışlaması (CUE), daha önceki kan bağışları, ve doğrulama testlerinin laboratuvar bulguları gibi veriler, kan vericileri yazılımından elde edilmiştir. Elde edilen veriler ki-kare testi kullanılarak SPSS ile değerlendirilmiştir. : 198,501 kan vericisinden 52,527'i (%26,46) ilk kez kan veren donörler, 145,974'i ise düzenli olarak kan verenler veya daha önce kan vermis olanlardı (%73,54). Vericilerin çoğu erkekti (%94,5), kadın verciler azınlıktaydı (5,5%). CUE seçeneği 2,237 (%1,13) verici tarafından kullanılmıştı. Bütün çalışma grubunda hepatit B yüzey antijeni (HBsAg) ve hepatit C virüsü (HCV) sıklığı sırasıyla 247 (%0,13) ve 134 (%0,0...

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Section: Discussionsupporting

confidence: 87%

“…Niazkar HR, et al: First-time Blood Donors in Southwest IranTurk J Hematol 2020;37:[30][31][32][33][34][35] …”

mentioning

confidence: 99%

First-Time Blood Donors are Double Edged Swords for Blood Transfusion Centers: a Retrospective Study in Southwest Iran

Niazkar¹,

Dorgalaleh²,

Rad³

2019

Tjh

Self Cite

View full text Add to dashboard Cite

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“…Similarly, a study conducted in Canada suggested that the CUE has a limited capacity to predict infections in the eclipse period (i.e., those that would not be revealed by the laboratory screening tests) and has rarely detected blood units from donors with exposures that had not been identified in the routine interview 18 . On the other hand, a study conducted in Iran showed that the CUE was associated with a higher prevalence of HBV, HCV and HIV 19 . Interestingly, a study from Germany showed that the proportion of donors opting for the CUE was higher when nurses conducted the interview when compared to medical doctors, and when the CUE form was submitted anonymously instead of being delivered to a provider.…”

Section: Discussionmentioning

confidence: 95%

Demographics and serological profile of blood donors who opt for the confidential unit exclusion in a blood bank in Sao Paulo, Brazil

Delatorre

Batalha

Santos

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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“…Presence of a centralized database will help preventing such donors from further blood donation. Alternatively, an option for confidential unit exclusion should also be provided to donors during pre-donation counselling, whereby they may give information anonymously of their at-risk blood donation without any peer/societal pressure [34].…”

Section: Discussionmentioning

confidence: 99%

Notification and follow‐up of blood donors reactive for transfusion‐transmitted infections: A narrative review of the literature from India

Chaurasia,

Patidar,

Pandey

et al. 2023

Vox Sanguinis

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Background and ObjectivesNotifying blood donors of their reactive status for transfusion‐transmitted infections (TTIs) plays a vital role in enabling early diagnosis and management while also preventing these donors from making future donation and transmission of the infectious agent. Given the limited data on donor notification processes in India, a narrative review was conducted to assess the existing notification process and identify areas requiring enhancement.Materials and MethodsWe conducted literature searches using PubMed, Google Scholar and Scopus, employing various keywords. The review included data on the year of the study, study design, donor numbers, TTI screening methods, sero‐reactive donor confirmation, notification frequency and methods, donor responses, post‐test counselling and risk factor assessment.ResultsOut of the 29 identified articles, 16 studies were included in the analysis. Repeat testing for initially reactive results was conducted in nine studies for 24.3% reactive donors. Phone calls were the primary notification method in most studies (8; 50%), with letters sent in cases of no response. Only 12 studies provided data on notified donors, revealing a notification rate of 71.2%. Of all initially reactive donors, 33.3% sought post‐test counselling. Data from six studies indicated that 74.3% of responsive donors had identifiable TTI risk factors.ConclusionOur review revealed significant variability in the notification processes across different studies. To enhance the management of TTI‐reactive donor notifications and responses, we recommend the establishment of universal protocols encompassing pre‐donation counselling, repeat/confirmatory testing, notification methods and comprehensive follow‐up and treatment.

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Confidential unit exclusion (CUE): Double edged sword for blood transfusion center: A ten-year study on volunteer blood donors in Kohgiluyeh and Boyer Ahmad province, Iran

Cited by 5 publications

References 18 publications

First-Time Blood Donors are Double Edged Swords for Blood Transfusion Centers: a Retrospective Study in Southwest Iran

First-Time Blood Donors are Double Edged Swords for Blood Transfusion Centers: a Retrospective Study in Southwest Iran

Demographics and serological profile of blood donors who opt for the confidential unit exclusion in a blood bank in Sao Paulo, Brazil

Notification and follow‐up of blood donors reactive for transfusion‐transmitted infections: A narrative review of the literature from India

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