Lhermitte's sign and vitamin B12 deficiency: case report

Abstract

CONTEXT AND OBJECTIVE: Lhermitte's sign, a classical neurological sign, is a rare manifestation of vitamin B12 deficiency. The aim here was to report on a case of an elderly patient with vitamin B12 deficiency whose first clinical manifestation was the presence of Lhermitte's sign. CASE REPORT:We describe an elderly patient with vitamin B12 deficiency who presented cognitive dysfunction, peripheral polyneuropathy and sensory ataxia, and whose first clinical manifestation was the presence of Lhermitte's sign. This sign is one of the rarest manifestations of vitamin B12 deficiency.

Lhermitte's Phenomenon and Platinum, Beware of Latency

“…Neck flexion may then result in mechanical deformity of the exposed neurons and produce the characteristic electric shock-like symptom [1,7]. The mechanism by which cisplatin might induce LS is poorly understood.…”