Artificial oxygen carriers as a possible alternative to red cells in clinical practice

Barbosa, Fabiano Timbó; Júca, Mário Jorge; Castro, Aldemar Araújo; Duarte, José Lira; Barbosa, Luciano Timbó

doi:10.1590/s1516-31802009000200008

Cited by 19 publications

(15 citation statements)

References 23 publications

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“…[26][27][28] In the experiments here, almost all generated microbubbles after the application of sonication had diameters of 1.5 µm, which were considered as fine microbubbles, including nanobubbles, suggesting that sonication is a useful method to generate finer microbubbles with nanobubbles ( Figure 2B). Sonication may divide generated microbubbles into finer MNBs.…”

Section: Discussionmentioning

confidence: 99%

Oxygen supersaturated fluid using fine micro/nanobubbles

Matsuki¹,

Ishikawa²,

Ichiba³

et al. 2014

IJN

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Microbubbles show peculiar properties, such as shrinking collapse, long lifetime, high gas solubility, negative electric charge, and free radical production. Fluids supersaturated with various gases can be easily generated using microbubbles. Oxygen microbubble fluid can be very useful for oxygen delivery to hypoxic tissues. However, there have been no reports of comparative investigations into adding fluids containing oxygen fine micro/nanobubbles (OFM-NBs) to common infusion solutions in daily medical care. In this study, it was demonstrated that OFMNBs can generate oxygen-supersaturated fluids, and they may be sufficiently small to infuse safely into blood vessels. It was found that normal saline solution is preferable for generating an oxygen-rich infusion fluid, which is best administered as a 30-minute intravenous infusion. It was also concluded that dextran solution is suitable for drug delivery substances packing oxygen gas over a 1-hour intravenous infusion. In addition, normal saline solution containing OFMNBs was effective for improving blood oxygenation. Thus, the use of OFMNB-containing fluids is a potentially effective novel method for improving blood oxygenation in cases involving hypoxia, ischemic diseases, infection control, and anticancer chemoradiation therapies.

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Section: Discussionmentioning

confidence: 99%

Oxygen supersaturated fluid using fine micro/nanobubbles

Matsuki¹,

Ishikawa²,

Ichiba³

et al. 2014

IJN

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“…These fine microbubbles were thought to be captured as the result of the gradual shrinking of microbubbles that finally collapse. Fine oxygen microbubbles are expected to have a variety of useful properties in medicine (Barbosa et al 2009;Betit 2009;Kulikovsky et al 2009). Microbubbles\10 lm in diameter are thought to be clinically safe; the filter pore sizes for cardiopulmonary bypass machines are usually in the range 28-40 lm, and oxygen microbubbles 10 lm in diameter are therefore negligibly small (Barak and Katz 2005).…”

Section: Discussionmentioning

confidence: 99%

Blood oxygenation using microbubble suspensions

et al. 2012

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Microbubbles have been used in a variety of fields and have unique properties, for example shrinking collapse, long lifetime, efficient gas solubility, a negatively charged surface, and the ability to produce free radicals. In medicine, microbubbles have been used mainly as diagnostic aids to scan various organs of the body, and they have recently been investigated for use in drug and gene delivery. However, there have been no reports of blood oxygenation by use of oxygen microbubble fluids without shell reagents. In this study, we demonstrated that nano or microbubbles can achieve oxygen supersaturation of fluids, and may be sufficiently small and safe for infusion into blood vessels. Although Po(2) increases in fluids resulting from use of microbubbles were inhibited by polar solvents, normal saline solution (NSS) was little affected. Thus, NSS is suitable for production of oxygen-rich fluid. In addition, oxygen microbubble NSS effectively improved hypoxic conditions in blood. Thus, use of oxygen microbubble (nanobubble) fluids is a potentially effective novel method for oxygenation of hypoxic tissues, for infection control, and for anticancer treatment.

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“…The smaller the bubble size, the higher the oxygen pressure (PO 2 ) values in water [6], suggesting that nannobubbles increase the PO 2 values in water to greater extent than that of microbubbles (10–50 µm in diameter) [1], [2]. It has been reported that high oxygen gas solubility of microbubbles is beneficial for oxygenation of hypoxic tissues [7], [8], [9], and their variable applications for medicine are expected to be useful [10], [11], [12]. Very recent ex vivo study has demonstrated that oxygen-nanobubble saline effectively improved hypoxic conditions of swine blood [2].…”

Section: Introductionmentioning

confidence: 99%

Oxygen and Air Nanobubble Water Solution Promote the Growth of Plants, Fishes, and Mice

et al. 2013

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Nanobubbles (<200 nm in diameter) have several unique properties such as long lifetime in liquid owing to its negatively charged surface, and its high gas solubility into the liquid owing to its high internal pressure. They are used in variety of fields including diagnostic aids and drug delivery, while there are no reports assessing their effects on the growth of lives. Nanobubbles of air or oxygen gas were generated using a nanobubble aerator (BUVITAS; Ligaric Company Limited, Osaka, Japan). Brassica campestris were cultured hydroponically for 4 weeks within air-nanobubble water or within normal water. Sweetfish (for 3 weeks) and rainbow trout (for 6 weeks) were kept either within air-nanobubble water or within normal water. Finally, 5 week-old male DBA1/J mice were bred with normal free-chaw and free-drinking either of oxygen-nanobubble water or of normal water for 12 weeks. Oxygen-nanobubble significantly increased the dissolved oxygen concentration of water as well as concentration/size of nanobubbles which were relatively stable for 70 days. Air-nanobubble water significantly promoted the height (19.1 vs. 16.7 cm; P<0.05), length of leaves (24.4 vs. 22.4 cm; P<0.01), and aerial fresh weight (27.3 vs. 20.3 g; P<0.01) of Brassica campestris compared to normal water. Total weight of sweetfish increased from 3.0 to 6.4 kg in normal water, whereas it increased from 3.0 to 10.2 kg in air-nanobubble water. In addition, total weight of rainbow trout increased from 50.0 to 129.5 kg in normal water, whereas it increased from 50.0 to 148.0 kg in air-nanobubble water. Free oral intake of oxygen-nanobubble water significantly promoted the weight (23.5 vs. 21.8 g; P<0.01) and the length (17.0 vs. 16.1 cm; P<0.001) of mice compared to that of normal water. We have demonstrated for the first time that oxygen and air-nanobubble water may be potentially effective tools for the growth of lives.

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Artificial oxygen carriers as a possible alternative to red cells in clinical practice

Cited by 19 publications

References 23 publications

Oxygen supersaturated fluid using fine micro/nanobubbles

Oxygen supersaturated fluid using fine micro/nanobubbles

Blood oxygenation using microbubble suspensions

Oxygen and Air Nanobubble Water Solution Promote the Growth of Plants, Fishes, and Mice

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